GEO DataSet Links for BioProject (Select 131267) - GEO DataSets

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Items: 2

Select item 2000233811.

Transcription profile of zebrafish hand2 (hanS6 allele) mutant embryos at 19hpf

(Submitter supplied) Heart formation requires the fusion of bilateral cardiomyocyte populations as they move toward the embryonic midline. The bHLH transcription factor Hand2 is essential for cardiac fusion; however, the effector genes that execute this function of Hand2 are unknown. Here, we provide the first evidence for a downstream component of the Hand2 pathway that mediates cardiac morphogenesis. Although hand2 is expressed in cardiomyocytes, mosaic analysis demonstrates that hand2 plays a non-autonomous role in regulating cardiomyocyte movement. more...

Organism:: Danio rerio

Type:: Expression profiling by array

Dataset:: GDS3735
Platform:: GPL1319
6 Samples

Download data: CEL

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Accession:: GSE23381

ID:: 200023381

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 37352.

Hand2 loss of function effect on embryonic heart

Analysis of Hand2 mutant embryo hearts at 19 hpf. Hand2 is a myocardial transcription factor essential for fusion of bilateral cardiomyocyte populations moving toward the embryonic midline. Results provide insight into downstream components of the Hand2 pathway that mediates cardiac morphogenesis.