GEO DataSets

Analysis of liver of 6 week old stearoyl-CoA desaturase 1 (SCD1) knockout females. SCD1 is a lipogenic enzyme that catalyzes the synthesis of monosaturated fatty acids. SCD1 null mutants have reduced body adiposity, increased insulin sensitivity, and are resistant to diet-induced weight gain.

Organism:

Mus musculus

Type:

Expression profiling by array, count, 2 genotype/variation sets

Platform:

GPL32

Series:

GSE2926

10 Samples

Download data: CEL, EXP

(Submitter supplied) Loss of stearoyl-CoA desaturase-1 function protects mice against adiposity. Ntambi JM, Miyazaki M, Stoehr JP, Lan H, Kendziorski CM, Yandell BS, Song Y, Cohen P, Friedman JM, Attie AD. Department of Biochemistry, University of Wisconsin, Madison, WI 53706, USA. ntambi@biochem.wisc.edu Stearoyl-CoA desaturase (SCD) is a central lipogenic enzyme catalyzing the synthesis of monounsaturated fatty acids, mainly oleate (C18:1) and palmitoleate (C16:1), which are components of membrane phospholipids, triglycerides, wax esters, and cholesterol esters. more...

Organism:

Mus musculus

Type:

Expression profiling by array

Dataset:

GDS1374

Platform:

GPL32

10 Samples

Download data: CEL, EXP

(Submitter supplied) To help elucidate the metabolic changes in the skin that contribute to the obesity resistance and skin pathology in mice lacking Scd1, we performed microarray analysis of skin gene expression in male skin Scd1 knockout (SKO) and Scd1 flox/flox control (Lox) mice fed a standard rodent diet. We identified an extraordinary number of differentially expressed genes that support the previously documented histological observations of sebocyte atrophy, inflammation and epidermal hyperplasia in SKO mice. more...

Organism:

Mus musculus

Type:

Expression profiling by array

Dataset:

GDS4910

Platform:

GPL1261

6 Samples

Download data: CEL

Analysis of skins of animals with skin-specific deletion of Scd1. Animals with skin-specific deletion of Scd1 develop severe sebaceous gland hypoplasia that results in progressive scarring alopecia. Results provide insight into the molecular basis of Scd1-deficient skin pathology

Organism:

Mus musculus

Type:

Expression profiling by array, count, 2 genotype/variation sets

Platform:

GPL1261

Series:

GSE24243

6 Samples

Download data: CEL

(Submitter supplied) β-caryophyllene (BCP) exhibits anti-proliferative properties in cancer cells. Here, we examine the hypothesis that BCP induces membrane remodeling. Our data show that high concentrations of BCP increase membrane permeability of human breast cells (hBrC) causing detachment and cell death. At a “sub-lethal” concentration of BCP, we show that BCP induces a striking upregulation of genes involved in cholesterol biosynthesis, including the gene that encodes for HMGCoA reductase (HMGCR), the rate-determining step in cholesterol biosynthesis. more...

Organism:

Homo sapiens

Type:

Expression profiling by high throughput sequencing

Platform:

GPL18573

9 Samples

Download data: TXT