Similar studies for GEO DataSets (Select 200002550) - GEO DataSets

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Items: 3

Select item 2000025501.

Gene expression profiling of Acute Promyelocytic Leukemia identifies two subtypes mainly associated with FLT3 ITD

(Submitter supplied) In this series we described the gene expression profiles of 18 APL patients using a high density DNA-oligonucleotide microarray (Agilent) representing about 20.000 genes demonstrating the presence of a very uniform expression pattern of APL cases among which two mainly types of gene profiles were recognized by unsupervised analysis. Relationship between these two subgroups and the different clinical, haematological and molecular APL features, comprising FLT3 status, were investigated. more...

Organism:: Homo sapiens

Type:: Expression profiling by array

Dataset:: GDS2242
Platform:: GPL887
18 Samples

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Accession:: GSE2550

ID:: 200002550

Select item 22422.

Acute promyelocytic leukemia

Analysis of bone marrow samples from 18 patients with acute promyelocytic leukemia (APL). Fms-like tyrosine kinase 3 (Flt3) is mutated in 35 to 40% of APL cases. Results provide insight into the role of Flt3 mutations in the pathogenesis of APL.