GEO DataSets

(Submitter supplied) Purpose: To identify genes and molecular mechanisms associated with disease progression during (7 weeks of age) and after (16 weeks) the peak of photoreceptor death in dogs affected with XLPRA2, a canine model of early-onset XLRP caused by a microdeletion in RPGR exon ORF15. Methods: Expression profiles of diseased and normal dog retinas at both ages were compared using a canine retinal custom cDNA microarray. more...

Organism:

Canis lupus familiaris

Type:

Expression profiling by array

Platform:

GPL9743

12 Samples

Download data: GPR

(Submitter supplied) To identify miRNAs associated with retinal development and degeneration in dogs affected with xlpra2, an early-onset canine retinal degeneration caused by a microdeletion in RPGRORF15. XLPRA2-mutant and normal retinas were selected at different ages for RNA extraction and hybridization on Affymetrix miRNA-specific microarrays.

Organism:

Canis lupus familiaris; synthetic construct

Type:

Non-coding RNA profiling by array

Platform:

GPL8786

22 Samples

Download data: CEL

(Submitter supplied) Mice were a mixed background between 129/SvEv and C57BL/6. Rp1 knockout mice (Rp1-/-) and wildtype littermates examined. At P7, P10, P14, P18 and P21, mice were sacrificed and retinas removed. Each RNA sample included a pool of neural retinas from 3-4 mice. Retinas were all collected at 1-2 pm. Keywords: other

Organism:

Mus musculus

Type:

Expression profiling by array

Dataset:

GDS1845

Platform:

GPL81

30 Samples

Download data: CEL

Analysis of retinas of animals disrupted for the retinitis pigmentosa 1 (RP1) gene. Animals examined up to postnatal day 21. Results provide insight into mechanisms underlying autosomal dominant progressive RP caused by RP1 mutations and identify molecules involved early in the disease process.

Organism:

Mus musculus

Type:

Expression profiling by array, count, 5 age, 2 genotype/variation sets

Platform:

GPL81

Series:

GSE128

30 Samples

Download data: CEL

(Submitter supplied) Photoreceptor disorders are collectively known as retinal degeneration (RD), and include retinitis pigmentosa (RP), cone-rod dystrophy and age related macular degeneration (AMD). These disorders are largely genetic in origin; individual mutations in any one of >200 genes cause RD, making mutation specific therapies prohibitively expensive. A better treatment plan, particularly for late stage disease, may involve stem cell transplants into the photoreceptor or ganglion cell layers of the retina. more...

Organism:

Mus musculus

Type:

Expression profiling by array

Platform:

GPL8321

20 Samples

Download data: CEL

(Submitter supplied) Genome-wide expression profiling of the retinoschisin deficient retina in C57CL/6 mice. Keywords: Genetic modification

Organism:

Mus musculus

Type:

Expression profiling by array

Dataset:

GDS2636

Platform:

GPL339

6 Samples

Download data

Analysis of retinas from postnatal day 7 mutants lacking retinoschisin (RS1h), an animal model for retinoschisis (RS). RS is a recessive retinal dystrophy accompanied by macular disease often resulting in early-onset vision loss. Results provide insight into the pathogenesis of RS.

Organism:

Mus musculus

Type:

Expression profiling by array, count, 2 genotype/variation sets

Platform:

GPL339

Series:

GSE5581

6 Samples

Download data

(Submitter supplied) Retinal ischemia is believed to initiate a series of events that leads to retinal neovascularization observed in several retinal diseases such as diabetetic retinopathy and retinal vein occlusion. Although some molecules such as VEGF and MCP-1 have been implicated in the process, its underlying mechanisms remain elusive. In order to identify genes associated with retinal ischemia, we performed gene expression analyses in retinas of mouse model of oxygen-induced retinopathy using DNA microarray technology.

Organism:

Mus musculus

Type:

Expression profiling by array

Platform:

GPL6481

9 Samples

Download data: TXT

(Submitter supplied) Dogs frequently develop glaucoma, a disease that leads to vision loss due to loss of retinal ganglion cells and degeneration of axons within the optic nerve. We used Affymetrix Gene chips to characterize transcriptional changes between healthy and glaucomatous retinas.

Organism:

Canis lupus familiaris

Type:

Expression profiling by array

Platform:

GPL3738

10 Samples

Download data: CEL