GEO DataSets

(Submitter supplied) Bioassay-guided fractionation of a cytotoxic extract derived from the Australian endemic plant Hernandia albiflora (twigs) resulted in the isolation of the two known compounds: deoxypodophyllotoxin and thalicthuberine. Both compounds were tested for their inhibition of LNCaP cell viability. Thalicthuberine (TH, IC50=2.0 µM) was selected for mechanism of action studies. Ongoing investigations have shown that TH induced a strong accumulation of LNCaP cells in mitosis, severe mitotic spindle defects and asymmetric cell divisions, ultimately leading to mitotic catastrophe accompanied by cell death through apoptosis. more...

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL16604

9 Samples

Download data: TXT

(Submitter supplied) The lack of a cure for metastatic prostate cancer (PCa) highlights the urgent need for more efficient drugs to fight this disease. Here, we report the molecular mechanism of action of the natural product 6-acetoxy-anopterine (6-AA) in malignant cells of the prostate. This potent cytotoxic alkaloid from the endemic Australian tree Anopterus macleayanus induced at low nanomolar doses a strong accumulation of LNCaP and PC3 PCa cells in mitosis, severe mitotic spindle defects and asymmetric cell divisions, ultimately leading to mitotic catastrophe accompanied by cell death through apoptosis. more...

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL16604

10 Samples

Download data: TXT

(Submitter supplied) Uncontrolled mitosis forms basis for tumor cell proliferation. Interference with normal mitotic progression often leads tumor cells to mitotic arrest. As a consequence, cell death follows, but not at all time. Reasonably, the antimitotic therapy has been proven effective and indispensable in the clinical treatment of cancer.Recently, we generated a 6H-Pyrido[2',1':2,3]imidazo[4,5-c] isoquinolin -5(6H)-one library, several products of which had been shown to possess antimitotic activities in vitro. more...

Organism:

Homo sapiens

Type:

Expression profiling by array

Dataset:

GDS3581

Platform:

GPL571

5 Samples

Download data: CEL

Analysis of HeLa cells treated for up to 12 hrs with MT7, an anti-mitotic compound from a combinatorial library. MT7 inhibits cell proliferation by arresting mitosis specifically and reversibly in various tumor cell lines of human origin. Results provide insight into the mechanism of action of MT7.

Organism:

Homo sapiens

Type:

Expression profiling by array, count, 2 agent, 5 time sets

Platform:

GPL571

Series:

GSE16378

5 Samples

Download data: CEL