Similar studies for GEO DataSets (Select 200233447) - GEO DataSets

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Items: 14

Select item 2002334471.

Single-cell transcriptome analysis of small cell neuroendocrine tumor of the endometrium reveals ISL1 as a potential biomarker for diagnosis and treatment

(Submitter supplied) In this study, we performed single-cell RNA sequencing on a specimen from a patient with endometrial neuroendocrine carcinoma pathologically diagnosed. By analyzing the data, we found that the expression of Islet-1 was significantly up-regulated in tumor cells. Furthermore, we verified it in neuroendocrine tumor cell lines, and obtained cells with high expression of Islet-1 and cells with low expression of Islet-1 by flow sorting. more...

Organism:: Homo sapiens

Type:: Expression profiling by high throughput sequencing

Platform:: GPL18573
4 Samples

Download data: MTX

Series

Accession:: GSE233447

ID:: 200233447

PubMed Similar studies

Select item 2001224392.

ISL1-binding site

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:: Homo sapiens

Type:: Expression profiling by high throughput sequencing; Genome binding/occupancy profiling by high throughput sequencing

Platform:: GPL16791
7 Samples

Download data: BED, XLSX

Series

Accession:: GSE122439

ID:: 200122439

PubMed Full text in PMC Similar studies

Select item 2001224373.

ISL1 predicts poor outcomes for patients with gastric cancer and drives tumor progression through binding to the ZEB1 promoter together with SETD7

(Submitter supplied) The goals of this study are to analyze the transcriptome profiling (RNA-seq) after ISL1 overexpression in SGC7901.

Organism:: Homo sapiens

Type:: Expression profiling by high throughput sequencing

Platform:: GPL16791
3 Samples

Download data: XLSX

Series

Accession:: GSE122437

ID:: 200122437

PubMed Full text in PMC Similar studies Analyze with GEO2R SRA Run Selector

Select item 2001220564.

Genome-wide maps of ISL1-binding site

(Submitter supplied) We report the high-throughput profiling of ISL1-binding sites in mammalian cells. By obtaining over four billion bases of sequence from chromatin immunoprecipitated DNA, we generated genome-wide ISL1-binding maps of SGC7901 cells. This study provides a prediction of regulated genes by the ISL1.

Organism:: Homo sapiens

Type:: Genome binding/occupancy profiling by high throughput sequencing

Platform:: GPL16791
4 Samples

Download data: BED

Series

Accession:: GSE122056

ID:: 200122056

PubMed Full text in PMC Similar studies SRA Run Selector

Select item 2000355105.

Isl1-Lhx3 fusion specifies motor neuron fate by inducing motor neuron genes and concomitantly suppressing the interneuron programs

(Submitter supplied) Combinatorial transcription codes generate the myriad of cell types during development, and thus likely provide crucial insights into directed differentiation of stem cells to a specific cell type. The LIM-complex composed of Isl1 and Lhx3 directs the specification of spinal motor neurons (MNs) in embryos. Here, we report that Isl1-Lhx3, a LIMcomplex-mimicking fusion, induces a signature of MN transcriptome and concomitantly suppresses interneuron differentiation programs, thereby serving as a potent and specific inducer of MNs in stem cells. more...

Organism:: Mus musculus

Type:: Expression profiling by high throughput sequencing

Platform:: GPL13112
4 Samples

Download data: TXT

Series

Accession:: GSE35510

ID:: 200035510

PubMed Full text in PMC Similar studies SRA Run Selector

Select item 2000010376.

Lung cancer

(Submitter supplied) Two prognostically significant subtypes of high-grade lung neuroendocrine tumors independent of small-cell and large-cell neuroendocrine carcinomas identified by gene expression profiles. BACKGROUND: Classification of high-grade neuroendocrine tumors (HGNT) of the lung currently recognises large-cell neuroendocrine carcinoma (LCNEC) and small-cell lung carcinoma (SCLC) as distinct groups. However, a similarity in histology for these two carcinomas and uncertain clinical course have led to suggestions that a single HGNT classification would be more appropriate. more...

Organism:: Homo sapiens

Type:: Expression profiling by array

Platform:: GPL962
91 Samples

Download data

Series

Accession:: GSE1037

ID:: 200001037

Select item 2000378177.

DNA methylation and expression profiling study for bladder cancer

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:: Homo sapiens

Type:: Expression profiling by array; Methylation profiling by array

Platforms:: GPL8490 GPL6102
48 Samples

Download data

Series

Accession:: GSE37817

ID:: 200037817

Select item 2000378168.

DNA methylation and expression profiling study for bladder cancer [methylation]

(Submitter supplied) The DNA methylation patterns associated with the development and progression of cancer. The aim of the present study was to identify novel methylation markers that can discriminate between normal and Non-muscle-invasive bladder cancer (NMIBC), and between good and poor prognosis using microarray analysis of DNA methylation and RNA expression patterns in NMIBC patients. From the 24 matched microarray-based DNA methylation and gene expression profiling data set, tumor specific hypermethylated genes were selected and clinical relevance of these genes were verified by quantitative PQS analyses. more...

Organism:: Homo sapiens

Type:: Methylation profiling by array

Platform:: GPL8490
24 Samples

Download data: TXT

Series

Accession:: GSE37816

ID:: 200037816

Select item 2000378159.

DNA methylation and expression profiling study for bladder cancer [gene expression]

Organism:: Homo sapiens

Type:: Expression profiling by array

Platform:: GPL6102
24 Samples

Download data: TXT

Series

Accession:: GSE37815

ID:: 200037815

Select item 20004444710.

BAI3, CDX2 and VIL1: a panel of three antibodies to distinguish small cell from large cell neuroendocrine lung carcinomas

(Submitter supplied) To identify potential markers for distinction of Small cell (SCLC) from large cell neuroendocrine (LCNEC) carcinoma, we have conducted the gene expression profiling on precisely isolated cancer cells and bronchial epithelial cells from these tumours and normal background lung. After statistical analysis and finding highly differentially expressed genes between these tumour groups, we performed qRT-PCR to delineate markers to test at protein level using immunohistochemistry. more...

Organism:: Homo sapiens

Type:: Expression profiling by array

Platform:: GPL14550
15 Samples

Download data: TXT

Series

Accession:: GSE44447

ID:: 200044447

Select item 20009330611.

Genome-wide mRNA expression analyses revealed dysregulation of genes important for sympathetic neuron development in isl1 cko and hypomorphic mutant embryos.

(Submitter supplied) Understanding factors that drive development and function of the sympathetic neuron is crucial to development of potential therapies for neuroblastoma. Here, we identify a key cell autonomous role for the LIM homeodomain transcription factor ISL1 for survival, proliferation and differentiation of sympathetic neurons throughout development. Analysis of several Isl1 mutant mouse lines, including one in which Isl1 was specifically ablated in sympathetic neuron (Wnt1-cre;Isl1 f/f) revealed an early requirement for Isl1 within sympathetic neurons for proliferation and surrvial. more...

Organism:: Mus musculus

Type:: Expression profiling by high throughput sequencing

Platform:: GPL13112
8 Samples

Download data: TXT

Series

Accession:: GSE93306

ID:: 200093306

PubMed Full text in PMC Similar studies SRA Run Selector

Select item 20009330412.

Genome-wide chromatin-immunoprecipitation studies of sympathetic neurons reveals critical direct targets of ISL1 and suggests potential co-factor families for ISL1 action in sympathetic neurons

(Submitter supplied) Understanding factors that drive development of the sympathetic neuron is crucial to development of potential therapies for neuroblastoma. Here, we identify a key cell autonomous role for the LIM homeodomain transcription factor ISL1 for survival, proliferation and differentiation of sympathetic neurons throughout development. Chromatin immunoprecipitation assays performed utilizing antibody to ISL1 in chromatin extracts from sympathetic neurons demonstrated that ISL1 directly binds genomic regions within several genes critical for sympathetic neuron development and function, including subunits of the Insm1, Lmo1,Tlx3 and Prox1. more...

Organism:: Mus musculus

Type:: Genome binding/occupancy profiling by high throughput sequencing

Platform:: GPL13112
2 Samples

Download data: BED

Series

Accession:: GSE93304

ID:: 200093304

PubMed Full text in PMC Similar studies SRA Run Selector

Select item 20006909713.

Genome-wide mRNA expression analyses revealed dysregulation of genes important for SAN function in Hcn4-CreERT2;Isl1 mutants.

(Submitter supplied) Understanding factors that drive development and function of the sinoatrial node (SAN) is crucial to development of potential therapies for sinus arrhythmias, including potential generation of biological pacemakers. Here, we identify a key cell autonomous role for the LIM homeodomain transcription factor ISL1 for survival, proliferation and function of pacemaker cells throughout development. Analysis of several Isl1 mutant mouse lines, including one in which Isl1 was specifically ablated in SAN (Hcn4- CreERT2;Isl1) revealed an early requirement for Isl1 within SAN for embryonic viability. more...

Organism:: Mus musculus

Type:: Expression profiling by high throughput sequencing

Platform:: GPL13112
2 Samples

Download data: TXT

Series

Accession:: GSE69097

ID:: 200069097

PubMed Full text in PMC Similar studies SRA Run Selector

Select item 20006897414.

Genome-wide chromatin-immunoprecipitation studies of purified SAN cells reveals critical direct targets of ISL1 and suggests potential co-factor families for ISL1 action in SAN cells

(Submitter supplied) Understanding factors that drive development and function of the sinoatrial node (SAN) is crucial to development of potential therapies for sinus arrhythmias, including potential generation of biological pacemakers. Here, we identify a key cell autonomous role for the LIM homeodomain transcription factor ISL1 for survival, proliferation and function of pacemaker cells throughout development. Chromatin immunoprecipitation assays performed utilizing antibody to ISL1 in chromatin extracts from FACS purified SAN cells demonstrated that ISL1 directly binds genomic regions within several genes critical for normal pacemaker function, including subunits of the L-type calcium channel, Ank2, and Tbx3. more...