Similar studies for GEO DataSets (Select 2432) - GEO DataSets

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Items: 4

Select item 24321.

Pituitary adenoma predisposition: whole blood

Analysis of whole blood from individuals with pituitary adenoma predisposition. Pituitary adenomas are common benign neoplasms characterized by oversecretion of growth hormone, leading to acromegaly. Results provide insight into the molecular basis of pituitary adenomas.

Organism:: Homo sapiens

Type:: Expression profiling by array, count, 2 disease state sets

Platform:: GPL570
Series:: GSE4488
16 Samples

Download data: CEL, EXP

DataSet

Accession:: GDS2432

ID:: 2432

Select item 2000044882.

Expression data from whole blood

(Submitter supplied) While identification of genes mutated in high penetrance tumor predisposition syndromes has been a success story, much less progress has been made in characterizing the genetic basis of low penetrance tumor susceptibility. Combining recently introduced chip-based technologies with traditional genealogy work we have identified inactivating germline mutations in patients with pituitary adenoma predisposition (PAP). more...

Organism:: Homo sapiens

Type:: Expression profiling by array

Dataset:: GDS2432
Platform:: GPL570
16 Samples

Download data: CEL, EXP

Series

Accession:: GSE4488

ID:: 200004488

Select item 2000379273.

AIP inactivation leads to pituitary tumorigenesis through defective Gαi-cAMP signaling

(Submitter supplied) Gene-level expression profiles of 7 Aip knock-out (triplicates from each) and 9 Aip wild-type mouse embryonic fibroblast cell lines were studied using Affymetrix GeneChip Mouse Exon 1.0 ST Arrays

Organism:: Mus musculus

Type:: Expression profiling by array

Platform:: GPL15555
30 Samples

Download data: CEL

Series

Accession:: GSE37927

ID:: 200037927

Select item 2000633574.

Identification of distinct molecular signatures in AIP mutation-positive familial isolated pituitary adenomas

(Submitter supplied) The aim of this study was to perform comparative gene expression analysis of AIP mutation-positive, AIP mutation-negative familial and sporadic somatotroph tumours to discover the genes/pathways responsible for the aggressive phenotype. Gene expression analysis was performed on 25 pituitary samples (five normal pituitary, six AIPpos GH, three AIPneg GH, four sporadic GH, two AIPneg familial NFPA and five sporadic NFPA adenomas) using the Affymetrix human Gene Chip HG-U133 Plus 2.0 array.