Similar studies for GEO DataSets (Select 4478) - GEO DataSets

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Items: 20

Select item 44781.

Analysis of Myc/DNp53-infected tumors derived from stem cells or progenitors, uninfected stem cells, and patched tumor cells. Cerebellar stem cells expressing Myc and mutant Trp53 generate tumors similar to MYC-driven medulloblastoma (MB). Results provide insight into transformation to MB tumor.

Organism:: Mus musculus

Type:: Expression profiling by array, transformed count, 4 cell type, 3 genotype/variation, 4 other sets

Platform:: GPL1261
Series:: GSE34126
19 Samples

Download data: CEL

DataSet

Accession:: GDS4478

ID:: 4478

PubMed Full text in PMC Similar studies GEO Profiles Analyze DataSet

Select item 2000341262.

An Animal Model of Myc-driven medulloblastoma

(Submitter supplied) Medulloblastoma (MB) is the most common malignant brain tumor in children. Patients whose tumors exhibit overexpression or amplification of the MYC oncogene (c-MYC) usually have an extremely poor prognosis, but there are no animal models of this subtype of the disease. Here we show that cerebellar stem cells expressing Myc and mutant Trp53 (p53) generate aggressive tumors following orthotopic transplantation. more...

Organism:: Mus musculus

Type:: Expression profiling by array

Dataset:: GDS4478
Platform:: GPL1261
19 Samples

Download data: CEL

Series

Accession:: GSE34126

ID:: 200034126

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 2001147603.

Remodeling Group 3 medulloblastoma: MYC overexpression alone transforms progenitors of astrocytes and granule neurons in the postnatal cerebellum

(Submitter supplied) Group 3 medulloblastoma is often associated with MYC amplification or overexpression, while whether MYC overexpression alone is sufficient to induce tumorigenesis is unknown and the cell type(s) which can be transformed by MYC is unclear. Here, by generating a new mouse model, we demonstrated that overexpression of Myc alone is sufficient to transform astrocyte progenitors and granule neuron progenitors (GNP) in the early postnatal cerebellum following orthotopic transplantation. more...

Organism:: Mus musculus

Type:: Expression profiling by high throughput sequencing

Platform:: GPL21103
21 Samples

Download data: TXT

Series

Accession:: GSE114760

ID:: 200114760

PubMed Full text in PMC Similar studies SRA Run Selector

Select item 2000774754.

Human neural stem cells transduced with oncogenic elements associated with aggressive medulloblastoma

(Submitter supplied) Human neural stem and progenitor cells transformed with c-MYC, dominant-negative p53, constitutively active AKT and hTERT formed tumors in mice that recapitulated Group 3 medulloblastoma in terms of pathology and expression profile

Organism:: Homo sapiens

Type:: Expression profiling by array

Platform:: GPL13158
6 Samples

Download data: CEL

Series

Accession:: GSE77475

ID:: 200077475

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 2000417175.

A macrophage autonomous α4β1integrin-Syk-Rac2 signaling axis controls macrophage differentiation, tumor growth and metastasis

(Submitter supplied) Macrophages, play an essential role in promoting tumor growth by affecting angiogenesis, immune suppression, invasion and metastasis. The signal transduction events within macrophages which encode the complex cascade of events required for tumor growth and polarization of macrophages are poorly understood. We have discovered an ECM dependent signaling pathway in macrophages that regulates M2 macrophage differentiation, tumor growth, invasion and metastasis. more...

Organism:: Mus musculus

Type:: Expression profiling by array

Platform:: GPL6246
12 Samples

Download data: CEL

Series

Accession:: GSE41717

ID:: 200041717

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 2000332016.

A mouse model of the most aggressive subgroup of human medulloblastoma

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:: Mus musculus

Type:: Expression profiling by array

Platforms:: GPL11180 GPL1261
79 Samples

Download data: CEL

Series

Accession:: GSE33201

ID:: 200033201

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 2000332007.

A mouse model of the most aggressive subgroup of human medulloblastoma [HT_MG-430_PM]

(Submitter supplied) A series of mouse models designed to mimic pediatric medulloblastoma types in humans were tested by microarray and compared to published human medulloblastoma data

Organism:: Mus musculus

Type:: Expression profiling by array

Platform:: GPL11180
15 Samples

Download data: CEL

Series

Accession:: GSE33200

ID:: 200033200

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 2000331998.

A mouse model of the most aggressive subgroup of human medulloblastoma [Mouse430_2]

(Submitter supplied) Mouse models of medulloblastoma are compared to human subgroups through microarray expression and other measures

Organism:: Mus musculus

Type:: Expression profiling by array

Platform:: GPL1261
64 Samples

Download data: CEL

Series

Accession:: GSE33199

ID:: 200033199

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 2000365949.

Transcriptome analysis of medulloblastoma tumors in mice

(Submitter supplied) The proto-oncogene MYCN is mis-expressed in various types of human brain tumors. To clarify how developmental and regional differences influence transformation, we transduced wild-type or mutationally-stabilized murine N-mycT58A into neural stem cells (NSCs) from perinatal murine cerebellum, brain stem and forebrain. Transplantation of Nmyc WT NSCs was insufficient for tumor formation. N-mycT58A cerebellar and brain stem NSCs generated medulloblastoma/primitive neuroectodermal tumors, whereas forebrain NSCs developed diffuse glioma. more...

Organism:: Mus musculus

Type:: Expression profiling by array

Platform:: GPL6096
56 Samples

Download data: CEL

Series

Accession:: GSE36594

ID:: 200036594

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 20006941010.

Myc-driven medulloblastoma cells treated with Panobinostat (LBH589)

(Submitter supplied) Mouse MycT58A/DNp53 (MP) medulloblastoma cells were treated with DMSO or HDAC inhibitor (HDACi) panobinostat for 6 or 12 hours in vitro. Gene expression profiling was performed to compare cells treated with panobinostat and DMSO.

Organism:: Mus musculus

Type:: Expression profiling by array

Platform:: GPL16570
12 Samples

Download data: CEL, CHP

Series

Accession:: GSE69410

ID:: 200069410

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 20001965711.

Targeting resistance to Smoothened antagonists by inhibiting the PI3K pathway

(Submitter supplied) Mutations in Hedgehog (Hh) pathway genes, leading to constitutive activation of Smoothened (Smo), occur in sporadic medulloblastoma, the most common brain cancer in children. Antagonists of Smo induce tumor regression in mouse models of medulloblastoma and hold great promise for targeted therapy for this tumor. However, acquired resistance has emerged as one of the major challenges of targeted cancer therapy. more...

Organism:: Mus musculus

Type:: Expression profiling by array; Genome variation profiling by genome tiling array

Platforms:: GPL4092 GPL1261
27 Samples

Download data: CEL, TXT

Series

Accession:: GSE19657

ID:: 200019657

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 20006262612.

Combined MYC and TP53 defects emerge at medulloblastoma relapse and define rapidly progressive, therapeutically targetable disease

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:: Mus musculus; Homo sapiens

Type:: Expression profiling by array; Genome variation profiling by genome tiling array

Platforms:: GPL13534 GPL6885
88 Samples

Download data: IDAT

Series

Accession:: GSE62626

ID:: 200062626

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 20006262513.

Combined MYC and TP53 defects emerge at medulloblastoma relapse and define rapidly progressive, therapeutically targetable disease [gene expression]

(Submitter supplied) We undertook a comprehensive clinical and biological investigation of serial medulloblastoma biopsies obtained at diagnosis and relapse. Combined MYC gene family amplifications and P53 pathway defects commonly emerged at relapse, and all patients in this molecular group died of rapidly progressive disease post-relapse. To study this genetic interaction, we investigated a transgenic model of MYCN-driven medulloblastoma and found spontaneous development of Trp53 inactivating mutations. more...

Organism:: Mus musculus

Type:: Expression profiling by array

Platform:: GPL6885
48 Samples

Download data: IDAT, TXT

Series

Accession:: GSE62625

ID:: 200062625

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 20006261814.

Methylation data from presentation and relapsed medulloblastoma tumour samples

Organism:: Homo sapiens

Type:: Methylation profiling by genome tiling array

Platform:: GPL13534
40 Samples

Download data: CSV

Series

Accession:: GSE62618

ID:: 200062618

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 20012821815.

A Patient-specific screen identifies Medulloblastoma driver genes in-vivo and in human organoids

(Submitter supplied) Group3 Medulloblastoma is a highly malignant pediatric brain tumor and despite patients harboring different genetic alterations they are treated with similar therapies. Here, we perform an in-vivo Patient-Specific screen and we identify Otx2 and c-Myc as strong inducers of Group3 Medulloblastoma. We demonstrate that the chromatin modifier Smarca4, also mutated in human patients, is able to reduce Otx2/c-Myc tumorigenic activity in-vivo. more...

Organism:: Homo sapiens

Type:: Methylation profiling by genome tiling array

Platform:: GPL21145
45 Samples

Download data: IDAT, TXT

Series

Accession:: GSE128218

ID:: 200128218

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 20008476116.

Inactivation of Ezh2 upregulates Gfi1 and drives aggressive Myc-driven Group 3 medulloblastoma [ChIP-Seq]

(Submitter supplied) The most aggressive of four medulloblastoma (MB) subgroups are cMYC-driven Group 3 (G3) tumors, some of which overexpress EZH2, the histone H3K27 trimethylase of polycomb repressive complex-2. Yet, engineered deletions of Ezh2 in G3 MBs by gene editing nucleases accelerated tumorigenesis, whereas Ezh2 re-expression reversed attendant histone modifications and slowed tumor progression. Candidate oncogenic drivers upregulated following Ezh2 deletion included Gfi1, a proto-oncogene frequently activated in human G3 MBs. more...

Organism:: Mus musculus

Type:: Genome binding/occupancy profiling by high throughput sequencing

Platform:: GPL16417
14 Samples

Download data: BED

Series

Accession:: GSE84761

ID:: 200084761

PubMed Full text in PMC Similar studies SRA Run Selector

Select item 20008446217.

Inactivation of Ezh2 upregulates Gfi1 and drives aggressive Myc-driven Group 3 medulloblastoma [RNA-Seq]

Organism:: Mus musculus

Type:: Expression profiling by high throughput sequencing

Platform:: GPL17021
48 Samples

Download data: TXT

Series

Accession:: GSE84462

ID:: 200084462

PubMed Full text in PMC Similar studies SRA Run Selector

Select item 20010740518.

Combined BET bromodomain and CDK2 inhibition in MYC-driven medulloblastoma

(Submitter supplied) MYC genes are frequently amplified and correlate with poor prognosis in MB. BET bromodomains recognize acetylated lysine residues and often promote and maintain MYC transcription. Certain cyclin-dependent kinases (CDKs) are further known to support MYC stabilization in tumor cells. In this report, MB cells were suppressed by combined targeting of MYC expression and MYC stabilization using BET bromodomain inhibition and CDK2 inhibition, respectively. more...

Organism:: Homo sapiens; Mus musculus

Type:: Expression profiling by high throughput sequencing

Platforms:: GPL16331 GPL17301
50 Samples

Download data: TSV

Series

Accession:: GSE107405

ID:: 200107405

PubMed Full text in PMC Similar studies SRA Run Selector

Select item 20014592119.

Genomic and transcriptomic analysis of medulloblastoma

(Submitter supplied) Identification of transcriptomic and genomic changes by RNA-seq, ATAC-seq and low coverage WGS in mouse and human tumor cells

Organism:: Mus musculus; Homo sapiens

Type:: Expression profiling by high throughput sequencing; Genome binding/occupancy profiling by high throughput sequencing; Genome variation profiling by high throughput sequencing