GEO DataSets

Analysis of colonic intestinal explants stimulated with PMA/IO to induce pro-inflammatory conditions then incubated with various commensal lactobacilli strains. Results provide insight into the molecular basis of probiotic attenuation of inflammatory processes in a colon organ culture model.

Organism:

Homo sapiens

Type:

Expression profiling by array, count, 2 agent, 4 protocol, 2 specimen sets

Platform:

GPL570

Series:

GSE23630

18 Samples

Download data: CEL

(Submitter supplied) Background: In the last decade, much attention has been drawn to probiotic bacteria in the context of inflammatory bowel disease (IBD), since the potential of certain strains to attenuate inflammation was demonstrated in several animal experiments and clinical studies. Data in humans elucidating the molecular mechanism of probiotic action are still scarce. To this end, we used an organ culture system of human colon mucosa and investigated the gene expression profiles after treatment with different probiotic bacteria in phorbol 12-myristate 13-acetate (PMA)/ionomycin (IO)) stimulated samples using whole genome microarrays. more...

Organism:

Homo sapiens

Type:

Expression profiling by array

Dataset:

GDS4548

Platform:

GPL570

18 Samples

Download data: CEL

(Submitter supplied) We investigated the transcriptome response of porcine intestinal epitheliocyte cell line (PIE cells) to the challenge with the Toll-like receptor 3 (TLR3) agonist poly(I:C) and, the changes induced by immunobiotic Lactobacillus rhamnosus CRL1505 (Lr1505) or Lactobacillus plantarum CRL1505 (Lp1506) in that response. The transcriptome approach allowed us to obtain a global overview of the immune and immune related genes involved in response of PIE cells to the viral pathogen-associated molecular pattern poly(I:C). more...

Organism:

Sus scrofa domesticus; Sus scrofa

Type:

Expression profiling by array

Platform:

GPL15007

4 Samples

Download data: TXT