Similar studies for GEO DataSets (Select 4977) - GEO DataSets

Select item 49771.

Nodular Lymphocyte Predominant Hodgkin Lymphoma and T Cell/Histiocyte Rich Large B Cell Lymphoma: microdissected tumor cells

Analysis of tumor cells microdissected from frozen sections of nodular lymphocyte predominant Hodgkin lymphoma (NLPHL), T cell/histiocyte rich large B cell lymphoma (THRLBCL), and THRLBCL-like NLPHL. Results provide insight into the molecular relatedness of the lymphoma entities.

Organism:: Homo sapiens

Type:: Expression profiling by array, transformed count, 4 cell type sets

Platform:: GPL6244
Series:: GSE47044
35 Samples

Download data: CEL

DataSet

Accession:: GDS4977

ID:: 4977

PubMed Full text in PMC Similar studies GEO Profiles Analyze DataSet

Select item 2000470442.

Nodular lymphocyte predominant hodgkin lymphoma and T cell/histiocyte rich large B cell lymphoma - endpoints of a spectrum of one disease?

(Submitter supplied) Tumor cells were microdissected from frozen sections of NLPHL and THRLBCL. RNA was amplified using the NUGEN WT-Ovation-One-direct-Kit. Samples were compared to tonsilar germinal center CD77 B cells.

Organism:: Homo sapiens

Type:: Expression profiling by array

Dataset:: GDS4977
Platform:: GPL6244
35 Samples

Download data: CEL

Series

Accession:: GSE47044

ID:: 200047044

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 2000424953.

Macrophages in T cell/histiocyte rich B cell lymphoma strongly express metal-binding proteins and show a bi-activated phenotype

(Submitter supplied) In a supervised principal component analysis, histiocytes from TCHRBCL were most closely related to epithelioid cells from NLPHL, with both types of cells expressing genes related to proinflammatory and regulatory macrophage activity.

Organism:: Homo sapiens

Type:: Expression profiling by array

Platform:: GPL6244
48 Samples

Download data: CEL

Series

Accession:: GSE42495

ID:: 200042495

Select item 2000077884.

Nodular lymphocyte predominant Hodgkin's lymphoma vs T cell/histiocyte rich B cell lymphoma

(Submitter supplied) T-cell/histiocyte rich B cell lymphoma (THRBL) and nodular lymphocyte predominant Hodgkin's lymphoma (NLPHL) share some morphological characteristics, including a prominent stromal reaction, but display a markedly different prognosis. To investigate the difference between the stromal reactions of these lymphomas at the molecular level, we performed microarray expression profiling on a series of THRBL and NLPHL cases. more...

Organism:: Homo sapiens

Type:: Expression profiling by array

Platform:: GPL570
21 Samples

Download data: CEL

Series

Accession:: GSE7788

ID:: 200007788

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 2000846885.

Gene expression profiling of the NLPHL cell line DEV after coculture with T cells and monocytes

(Submitter supplied) Nodular lymphocyte predominant Hodgkin lymphoma (NLPHL) is an indolent lymphoma, but can transform into diffuse large B cell lymphoma (DLBCL), showing a more aggressive clinical behavior. Little is known about these cases on the molecular level. Therefore, the aim of the present study was to characterize DLBCL transformed from NLPHL (LP-DLBCL) by gene expression profiling (GEP). GEP revealed an inflammatory signature pinpointing to a specific host response. more...

Organism:: Homo sapiens

Type:: Expression profiling by array

Platform:: GPL6244
6 Samples

Download data: CEL

Series

Accession:: GSE84688

ID:: 200084688

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 2000844646.

Genexpression Profiling of DLBCL derived from NLPHL

Organism:: Homo sapiens

Type:: Expression profiling by array

Platform:: GPL6244
29 Samples

Download data: CEL

Series

Accession:: GSE84464

ID:: 200084464

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 2002059197.

The identification of TCF1+ progenitor exhausted T-cells in THRLBCL may predict a better response to PD-1/PD-L1 blockade

(Submitter supplied) T-cell/histiocyte rich large B-cell lymphoma (THRLBCL) is a rare and aggressive variant of diffuse large B cell lymphoma (DLBCL) that usually affects young to middle-aged patients, with disseminated disease at presentation. The tumor microenvironment (TME) plays a key role in THRLBCL, due to its peculiar cellular composition (less than 10% neoplastic B-cells interspersed in a cytotoxic T-cell/histiocyte rich background). more...

Organism:: Homo sapiens

Type:: Expression profiling by array

Platform:: GPL29738
22 Samples

Download data: RCC, TXT

Series

Accession:: GSE205919

ID:: 200205919

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Select item 2000124538.

Origin and pathogenesis of lymphocyte-predominant Hodgkin lymphoma as revealed by global gene expression analysis

(Submitter supplied) The pathogenesis of nodular lymphocyte-predominant Hodgkin lymphoma (NLPHL) and its relationship to other lymphomas are largely unknown. This is partly due to the technical challenge of analyzing its rare neoplastic L&H cells, which are dispersed in an abundant non-neoplastic cellular microenvironment. We performed a genome-wide expression study of microdissected lymphocytic and histiocytic (L&H) lymphoma cells in comparison to normal and other malignant B cells, which indicates a relationship of L&H cells to and/or origin from germinal center B cells at transition to memory B cells. more...

Organism:: Homo sapiens

Type:: Expression profiling by array

Dataset:: GDS3516
Platform:: GPL570
67 Samples

Download data: CEL

Series

Accession:: GSE12453

ID:: 200012453

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 35169.

Nodular lymphocyte-predominant Hodgkin lymphoma: lymphocytic and histiocytic cells

Analysis of neoplastic lymphocytic and histiocytic cells (L&H) dissected from nodular lymphocyte-predominant Hodgkin lymphoma tumors (NLPHL). L&H cells represent less than 1 percent of cells in NLPHL tumors. Results provide insight into the pathogenesis of NLPHL.

Organism:: Homo sapiens

Type:: Expression profiling by array, count, 11 disease state sets

Platform:: GPL570
Series:: GSE12453
67 Samples

Download data: CEL

DataSet

Accession:: GDS3516

ID:: 3516

PubMed Full text in PMC Similar studies GEO Profiles Analyze DataSet

Select item 20002129610.

Expression data of cHL cell lines after KLF4 activation

(Submitter supplied) Characteristic extinguishing of B-cell phenotype in cHL is believed to be a result of transcription factor network deregulation due to the overexpression of repressor proteins ID2 and ABF-1. KLF4 is a versatile transcription factor, participating in regulation of differentiation processes in various tissues. Epigenetic silencing of KLF4 in cHL hints that KLF4 is involved in the complex mechanism of extinguishing of B-cell phenotype in cHL. more...

Organism:: Homo sapiens

Type:: Expression profiling by array

Platform:: GPL6244
8 Samples

Download data: CEL

Series

Accession:: GSE21296

ID:: 200021296

Select item 20022575911.

Gene Expression Signatures for the Accurate Diagnosis of Peripheral T-Cell Lymphoma Entities in the Routine Clinical Practice

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:: Homo sapiens

Type:: Other

Platform:: GPL33154
272 Samples

Download data: RCC

Series

Accession:: GSE225759

ID:: 200225759

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 20022575812.

Gene Expression Signatures for the Accurate Diagnosis of Peripheral T-Cell Lymphoma Entities in the Routine Clinical Practice [validation]

(Submitter supplied) Peripheral T-cell lymphoma (PTCL) includes heterogeneous clinicopathologic entities with numerous diagnostic and treatment challenges. We previously defined robust transcriptomic signatures that distinguish common PTCL entities and identified two novel biologic and prognostic PTCL-not otherwise specified subtypes (PTCL-TBX21 and PTCL-GATA3). We aimed to consolidate a gene expression–based subclassification using formalin-fixed, paraffin-embedded (FFPE) tissues to improve the accuracy and precision in PTCL diagnosis. more...