GEO DataSet Links for PMC (Select 2481274) - GEO DataSets

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Items: 2

Select item 2000149051.

Type I Interferon: Potential Therapeutic Target for Psoriasis?

(Submitter supplied) We observed robust overexpression of type I interferon (IFN)–inducible genes and genomic signatures that indicate T cell and dendritic cell infiltration in lesional skin. Up-regulation of mRNAs for IFN-a subtypes was observed in lesional skin compared with nonlesional skin. Enrichment of mature dendritic cells and 2 type I IFN–inducible proteins, STAT1 and ISG15, were observed in the majority of lesional skin biopsies. more...

Organism:: Homo sapiens

Type:: Expression profiling by array

Dataset:: GDS3539
Platform:: GPL570
82 Samples

Download data: CEL

Series

Accession:: GSE14905

ID:: 200014905

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 35392.

Psoriasis

Analysis of lesional and non-lesional skins from patients with psoriasis. Psoriasis is an immune-mediated disease characterized by aberrant epidermal differentiation, surface scale formation, and marked cutaneous inflammation. Results provide insight into the molecular pathogenesis of psoriasis.