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Items: 1 to 20 of 767

1.

Functional and Structural Segregation of Overlapping Helices in HIV-1

(Submitter supplied) We report deep mutational scanning data for the Env protein's LLP-2 domain in the NL4-3 strain HIV-1 Env. Processed Data repersents counts for each amino acid pre and post spread
Organism:
Human immunodeficiency virus 1
Type:
Other
Platform:
GPL23868
76 Samples
Download data: TAB
Series
Accession:
GSE179046
ID:
200179046
2.

Epitranscriptomic addition of m6A regulates HIV-1 RNA stability and alternative splicing

(Submitter supplied) Several prior reports have demonstrated that the epitranscriptomic addition of m6A to viral transcripts promotes the replication and pathogenicity of a wide range of viruses yet the underlying mechanism(s) causing this positive effect has remained unclear. It is known that m6A function is largely mediated by cellular m6A binding proteins or readers, however, how these m6A reader proteins contribute to the regulation of HIV-1 gene expression has remained controversial. more...
Organism:
Homo sapiens; Human immunodeficiency virus 1
Type:
Other
Platform:
GPL18160
3 Samples
Download data: BED
Series
Accession:
GSE165473
ID:
200165473
3.

Expression analysis of microRNAs in INT-HA-induced M2-like macrophages and untreated macrophages (M0)

(Submitter supplied) Using the highly sensitive miRNA microarray, we screened 107 up-regulated microRNAs and 33 down-regulated microRNAs in the INT-HA-induced M2-like macrophages and we explored the functions of these miRNAs in macrophage polarization. The enrichment results indicated that these miRNAs might participate in the process of macrophage polarization. Furthermore, the quantitative real-time polymerase chain reaction results showed that miR-935 may play an important role in M2 macrophage polarization which was activated by INT-HA.
Organism:
Herpesvirus saimiri (strain 11); JC polyomavirus; Macaca mulatta polyomavirus 1; Human immunodeficiency virus 1; Human betaherpesvirus 6B; Human alphaherpesvirus 2; Merkel cell polyomavirus; Homo sapiens; Human polyomavirus 1
Type:
Non-coding RNA profiling by array
Platform:
GPL24594
6 Samples
Download data: GPR
Series
Accession:
GSE110339
ID:
200110339
4.

Differentially expressed microRNAs in the mouse liver with T3 treatment

(Submitter supplied) An improved mechanistic understanding of the thyroid hormone (TH) action on bile acid (BA) synthetic pathway, the major route for cholesterol elimination, will facilitate the identification of novel therapeutic targets for hypercholesterolemia. Here, we show that hepatic miR-378 is positively regulated by TH. Transient overexpression of miR-378 in the liver of mice reduces the serum cholesterol levels, which is accompanied with an upregulation of key enzymes involved in the intrahepatic conversion of cholesterol to BAs. more...
Organism:
Homo sapiens; Mus musculus; Human alphaherpesvirus 1; Human betaherpesvirus 5; Murid betaherpesvirus 1; Human gammaherpesvirus 4; Human immunodeficiency virus 1; JC polyomavirus; Human gammaherpesvirus 8; Macaca mulatta polyomavirus 1; Murid gammaherpesvirus 4; Human polyomavirus 1; Rattus norvegicus
Type:
Non-coding RNA profiling by array
Platform:
GPL20794
1 Sample
Download data: TXT, XLS
Series
Accession:
GSE139961
ID:
200139961
5.

The difference of microRNA profiles among control, normal high density lipoprotein-treated and proflammatory high density lipoprotein-treated endothelial cells

(Submitter supplied) The potential mechanism were successfully illustrated through detecting different expression of microRNAs in between proinflammatory high density lipprotein (pHDL), nomal high density lipprotein (nHDL) and control group, to study whether microRNAs play important roles in the endothelial dysfunction caused by pHDL.
Organism:
Human immunodeficiency virus 1; JC polyomavirus; Homo sapiens; Rhadinovirus; Human alphaherpesvirus 2; Lymphocryptovirus; Merkel cell polyomavirus
Type:
Non-coding RNA profiling by array
Platform:
GPL29064
3 Samples
Download data: XLS
Series
Accession:
GSE156800
ID:
200156800
6.

Complementation can maintain a quasispecies of drug sensitive and resistant HIV

(Submitter supplied) The goal of this study was to determine how an HIV quasispecies is maintained in the face of selection. We deep sequenced the HIV provirus from cell populations as well as single cells at different time points from in vitro evolution experiments and found that when a less fit and more fit infect the same cell, they share components (complmentation) and therefore allow the less fit to perpetuate. We reproduced a quasispecies to an HIV reverse transcriptase inhibitor. more...
Organism:
Human immunodeficiency virus 1
Type:
Genome variation profiling by high throughput sequencing
Platform:
GPL23868
207 Samples
Download data: CSV
Series
Accession:
GSE150390
ID:
200150390
7.

HIV-1 RNA structure and heterogeneity analysis

(Submitter supplied) The goal of this set of experiments is to determine the structure of HIV-1 NL4-3 and NHG RNA structure using a novel algorithm that allows for the identification of multiple RNA folding conformations. The input data used for this algorithm is DMS-MaPseq data. We focused on two specific areas of the HIV-1 genome, the Rev Response Element (RRE) and A3 splice acceptor site, as well as probing the whole HIV-1 genome. more...
Organism:
Human immunodeficiency virus 1; synthetic construct; Vibrio vulnificus; Homo sapiens
Type:
Other
7 related Platforms
23 Samples
Download data: TXT
Series
Accession:
GSE131506
ID:
200131506
8.

miRNA profile in the hippocampus of APP/PS1 transgenic mice

(Submitter supplied) To explore the miRNAs associated with the memory deficits in Alzheimer's disease, we detected the miRNA profiles in the hippocampus of 6-month-old male APPswe/PS1dE9 (APP/PS1) mice and age-matched wild type C57BL/6 mice.
Organism:
Herpesvirus saimiri (strain 11); JC polyomavirus; Human gammaherpesvirus 8; Macaca mulatta polyomavirus 1; Human polyomavirus 1; Homo sapiens; Mus musculus; Human alphaherpesvirus 1; Macacine alphaherpesvirus 1; Human betaherpesvirus 5; Human gammaherpesvirus 4; Human immunodeficiency virus 1; Human alphaherpesvirus 2; Human betaherpesvirus 6B; Merkel cell polyomavirus
Type:
Non-coding RNA profiling by array
Platform:
GPL21439
6 Samples
Download data: GPR
Series
Accession:
GSE138382
ID:
200138382
9.

Comparison of microRNA expression profiles in soft palate muscle of patients with OSAHS and chronic tonsillitis.

(Submitter supplied) The expression profile of miRNAs in soft palate muscle of patients with OSAHS (obstructive sleep apnea/hypopnea syndrome) and chronic tonsillitis was examined using miRNA microarray analysis. Combining with the following real time PCR and bioinformatics analysis, the physiological importance of the miRNA-autophagy interconnection is far more likely to be elucidated.
Organism:
Human alphaherpesvirus 1; Cytomegalovirus; Lymphocryptovirus; Macaca mulatta polyomavirus 1; Human alphaherpesvirus 2; JC polyomavirus; Homo sapiens; Rhadinovirus; Human immunodeficiency virus 1; Merkel cell polyomavirus; Human polyomavirus 1
Type:
Non-coding RNA profiling by array
Platform:
GPL19128
8 Samples
Download data: GPR, TXT
Series
Accession:
GSE99239
ID:
200099239
10.

MicroRNA-mediated suppression of the TGF-β pathway confers transmissible and reversible CDK4/6 inhibitor resistance

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.
Organism:
Homo sapiens; Rhadinovirus; Merkel cell polyomavirus; Human alphaherpesvirus 1; Cytomegalovirus; Lymphocryptovirus; Macaca mulatta polyomavirus 1; Human alphaherpesvirus 2; JC polyomavirus; Human immunodeficiency virus 1; Human polyomavirus 1
Type:
Expression profiling by array; Expression profiling by high throughput sequencing; Non-coding RNA profiling by array; Non-coding RNA profiling by high throughput sequencing
Platforms:
GPL18573 GPL571 GPL19128
75 Samples
Download data: CEL, TXT
Series
Accession:
GSE117748
ID:
200117748
11.

MicroRNA-mediated suppression of the TGF-ß pathway confers transmissible and reversible CDK4/6 inhibitor resistance (miRNA array)

(Submitter supplied) CDK4/6 inhibition is now part of the standard armamentarium for patients with estrogen receptor (ER)-positive breast cancer, so that defining mechanisms of resistance is a pressing issue. Here, we identify increased CDK6 expression as a key determinant of acquired resistance after exposure to palbociclib in ER-positive breast cancer cells. Increased CDK6 in resistant cells was dependent on TGF-β pathway suppression via miR-432-5p expression. more...
Organism:
Cytomegalovirus; Human polyomavirus 1; JC polyomavirus; Human immunodeficiency virus 1; Merkel cell polyomavirus; Human alphaherpesvirus 2; Lymphocryptovirus; Homo sapiens; Human alphaherpesvirus 1; Rhadinovirus; Macaca mulatta polyomavirus 1
Type:
Non-coding RNA profiling by array
Platform:
GPL19128
9 Samples
Download data: TXT
Series
Accession:
GSE117745
ID:
200117745
12.

A focused deep mutational scan on the Env transmembrane and proximal cytosolic regions reveals an absence of sequence features for MA association

(Submitter supplied) The HIV-1 surface glycoprotein Env binds target receptors to mediate fusion of the viral and host cell membranes during infection. Env is incorporated with very low density into virions, and in some cell types, regions within the long cytosolic C-terminal tail may mediate direct or indirect associations with Gag during virus assembly and budding. Here, the mutational landscape is determined across the transmembrane and proximal cytosolic domains of Env (001428 isolate from clade C) interacting with the MA domain of Gag at cellular membranes. more...
Organism:
Human immunodeficiency virus 1
Type:
Other
Platform:
GPL23868
5 Samples
Download data: XLSX
13.

Mutational tolerance of HIV-1 Env in the CD4, VRC01 and PG16 bound states

(Submitter supplied) HIV-1 infection begins with binding of the viral envelope glycoprotein Env to the host receptor CD4, triggering a series of conformational changes that lead to fusion of the virus and cell membranes. Env, a trimer of gp120 and gp41 subunits, occupies a ‘closed’ conformation with contacts between gp120 subunits at the apex, and transitions through an ‘open’ conformation with the gp120 subunits spread apart following CD4 binding. more...
Organism:
Human immunodeficiency virus 1
Type:
Other
Platforms:
GPL22068 GPL23868
21 Samples
Download data: XLSX
14.

Deep mutational scanning of Env from the HIV-1 strain DU422 for binding to CD4 and PG16

(Submitter supplied) The HIV-1 genome gains access to the inside of a cell via the mechanism of the viral spike protein Env, which undergoes a series of major conformational rearrangements after binding target receptors that ultimately drive virus-cell membrane fusion. Env is expressed as a heterogenous ensemble of conformations, which can inappropriately misdirect the host immune response towards the production of non-protective, strain-specific antibodies. more...
Organism:
Human immunodeficiency virus 1
Type:
Other
Platform:
GPL22068
22 Samples
Download data: XLSX
15.

microRNA responses of LPS and IL-10 stimulated primary human monocyte-derived macrophages over a short time-course

(Submitter supplied) Lipopolysaccharide stimulated primary human monocyte-derived macrophages at 2, 4 and 8hrs, IL-10 at 4hrs, IL-10+LPS at 4hrs
Organism:
Rattus norvegicus; Homo sapiens; Mus musculus; Human alphaherpesvirus 1; Human betaherpesvirus 5; Murid betaherpesvirus 1; Human gammaherpesvirus 4; Human immunodeficiency virus 1; JC polyomavirus; Human gammaherpesvirus 8; Macaca mulatta polyomavirus 1; Murid gammaherpesvirus 4; Human polyomavirus 1
Type:
Non-coding RNA profiling by array
Platform:
GPL7722
6 Samples
Download data: TXT
Series
Accession:
GSE125572
ID:
200125572
16.

Microarray-based miRNA expression,identified miRNAs that were regulated by KSHV vIRF1

(Submitter supplied) HUVECs were transduced with lentiviral vIRF1 or control lentivirus (pHAGE),microarray-based miRNA expression profiling was adopted and identified a set of miRNAs that were differentially expressed between vIRF1- and pHAGE-transduced HUVECs
Organism:
Homo sapiens; Macacine alphaherpesvirus 1; Merkel cell polyomavirus; Human polyomavirus 1; Human alphaherpesvirus 1; Human betaherpesvirus 5; Human betaherpesvirus 6B; Macaca mulatta polyomavirus 1; Human alphaherpesvirus 2; Human gammaherpesvirus 4; Herpesvirus saimiri (strain 11); JC polyomavirus; Human immunodeficiency virus 1; Human gammaherpesvirus 8
Type:
Non-coding RNA profiling by array
Platforms:
GPL20712 GPL21439
6 Samples
Download data: TXT
Series
Accession:
GSE119034
ID:
200119034
17.

human serum: Control vs. patients with repeated implantation failure

(Submitter supplied) microRNAs profiling of human serum comparing control fertile women with women who had experienced repeated implantation failure after ovarian stimulation and IVF-ET. Repeated implantation failure was defined as women who had undergone≥3 failed cycles with high-grade embryos were transferred.
Organism:
Human alphaherpesvirus 1; Cytomegalovirus; Macaca mulatta polyomavirus 1; Human alphaherpesvirus 2; Lymphocryptovirus; Homo sapiens; Rhadinovirus; Merkel cell polyomavirus; Human polyomavirus 1; JC polyomavirus; Human immunodeficiency virus 1
Type:
Non-coding RNA profiling by array
Platform:
GPL19128
6 Samples
Download data: GPR, TXT
Series
Accession:
GSE106307
ID:
200106307
18.

Differentially expressed miRNA in biological premature ovarian insufficiency (bPOI)

(Submitter supplied) We first examined changes of miRNAs and expression using microarrays ( Exiqon miRCURY™ microarray LNA v.18.0) of GCs from 10 bPOI and 10 age and BMI matched normal control women. Seventy-five miRNAs (Fold Change [FC]>2, P<0.05) were identified differentially expressed between bPOI patients and control women.
Organism:
JC polyomavirus; Human immunodeficiency virus 1; Merkel cell polyomavirus; Human alphaherpesvirus 1; Human alphaherpesvirus 2; Lymphocryptovirus; Cytomegalovirus; Human polyomavirus 1; Macaca mulatta polyomavirus 1; Homo sapiens; Rhadinovirus
Type:
Non-coding RNA profiling by array
Platform:
GPL19128
20 Samples
Download data: GPR, TXT
Series
Accession:
GSE100238
ID:
200100238
19.

Mechanical stretch induced transcriptomic profiles in cardiac myocytes

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.
Organism:
Murid gammaherpesvirus 4; Human polyomavirus 1; JC polyomavirus; Human gammaherpesvirus 8; Macaca mulatta polyomavirus 1; Homo sapiens; Mus musculus; Human alphaherpesvirus 1; Human betaherpesvirus 5; Murid betaherpesvirus 1; Human gammaherpesvirus 4; Human immunodeficiency virus 1; Rattus norvegicus
Type:
Non-coding RNA profiling by array
Platform:
GPL7722
20 Samples
Download data
Series
Accession:
GSE107380
ID:
200107380
20.

Mechanical stretch induced transcriptomic profiles in cardiac myocytes [24-48 hours]

(Submitter supplied) The effect of cyclic mecanical stretch on cardiac microRNA expression was studied in neonatal rat ventricular myocytes (NRVMs).
Organism:
Rattus norvegicus; JC polyomavirus; Human gammaherpesvirus 8; Macaca mulatta polyomavirus 1; Homo sapiens; Mus musculus; Human alphaherpesvirus 1; Human betaherpesvirus 5; Murid betaherpesvirus 1; Human immunodeficiency virus 1; Human gammaherpesvirus 4; Murid gammaherpesvirus 4; Human polyomavirus 1
Type:
Non-coding RNA profiling by array
Platform:
GPL7722
9 Samples
Download data: XLS
Series
Accession:
GSE107379
ID:
200107379
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