GEO DataSets

(Submitter supplied) To address the role of miRNAs in Hirschsprund disease (HSCR), we carried out microRNA (miRNA) array analysis by using human intestinal samples obtained from HSCR patients and controls, and identified dysregulated miRNAs involved in the pathogenesis of HSCR.

Organism:

Merkel cell polyomavirus; Homo sapiens; Herpesvirus saimiri (strain 11); JC polyomavirus; Human gammaherpesvirus 8; Human alphaherpesvirus 1; Human betaherpesvirus 5; Human immunodeficiency virus 1; Human betaherpesvirus 6B

Type:

Non-coding RNA profiling by array

Platform:

GPL32145

10 Samples

Download data: GPR, TXT

(Submitter supplied) Innate cellular defense mechanisms and viral countermeasures govern the outcome of pathogen exposure but the complex virus-host interplay remains poorly understood. Here, we developed a virus-guided technology platform where the pathogen itself reveals its cellular opponents. To accomplish this, we engineered replication-competent HIV-1 expressing single guide RNAs (sgRNAs) targeting potential antiviral genes in Cas9 expressing CD4+ T cells. more...

Organism:

Human immunodeficiency virus 1

Type:

Other

Platform:

GPL33848

49 Samples

Download data: TAB, XLSX

(Submitter supplied) The mechanism by which aging induces aortic aneurysm and dissection (AAD) remains unclear. A total of 430 subjects were recruited for screening of differentially expressed plasma microRNAs. We found that miR-1204 was significantly increased in both plasma and aorta of elder patients with AAD, and was positively correlated with age. Cell senescence induced the expression of miR-1204 through p53 interaction with plasmacytoma variant translocation 1, and miR-1204 induced vascular smooth muscle cell (VSMC) senescence to form a positive feedback loop. more...

Organism:

Human alphaherpesvirus 2; human gammaherpesvirus 4; Human betaherpesvirus 6B; Betapolyomavirus macacae; Herpesvirus saimiri (strain 11); JC polyomavirus; Human gammaherpesvirus 8; Betapolyomavirus hominis; Homo sapiens; Human alphaherpesvirus 1; Macacine alphaherpesvirus 1; Human betaherpesvirus 5; Human immunodeficiency virus 1; Merkel cell polyomavirus

Type:

Non-coding RNA profiling by array

Platform:

GPL21439

12 Samples

Download data: GPR, XLSX

(Submitter supplied) The analysis of RNA-sequencing data reveals the proportion of the three viruses simultaneously inoculated into humanized mice.

Organism:

Human immunodeficiency virus 1

Type:

Other

Platform:

GPL23868

17 Samples

Download data: TXT

(Submitter supplied) Excessive alcohol consumption adversely affects the immune system and triggers the activation of peripheral blood (PB) monocytes and tissue macrophages, contributing to alcohol- related organ damage. This study aimed to analyze the M1/M2 and inflammatory phenotypes of circulating monocytes and macrophage-derived monocytes (MDMs). This single-center cross- sectional study included 20 excessive alcohol drinkers (EADs) and 22 healthy controls. more...

Organism:

Rattus norvegicus; Human alphaherpesvirus 2; Merkel cell polyomavirus; Mus musculus cytomegalovirus 2; Murid gammaherpesvirus 4; Betapolyomavirus hominis; human gammaherpesvirus 4; JC polyomavirus; Human gammaherpesvirus 8; Betapolyomavirus macacae; Homo sapiens; Mus musculus; Human alphaherpesvirus 1; Human betaherpesvirus 5; Murid betaherpesvirus 1; Human immunodeficiency virus 1

Type:

Non-coding RNA profiling by array

Platform:

GPL11434

22 Samples

Download data: GPR, TXT

(Submitter supplied) Chimeric antigen receptor T (CAR-T) cells, long proposed for HIV-1 treatment, has yet to achieve desirable therapeutic efficacy. In our study, M10 CAR-T cells were used for treating 18 HIV-1 patients via a regimen combining two M10 infusions and repeat chidamide stimulation for HIV reservoir activation. Consequently, 74.3% of M10 infusions resulted in significant suppression of viral rebound (averaging 77.4% decline), with 10 patients showing persistently reduced cell-associated HIV-1 RNA levels (averaging > 1.15 log10) over the 150-day observation period. more...

Organism:

Human immunodeficiency virus 1

Type:

Other

Platforms:

GPL32911 GPL32910

26 Samples

Download data: FA, TXT

(Submitter supplied) Silencing of the adaptor SH3BP2 impairs Gastrointestinal stromal tumors growth through miRNAs We dissected SH3BP2 pathway in Gastrointestinal Stromal Tumor cells (GIST) performing a miRNA array in SH3BP2-silenced GIST cells

Organism:

Herpesvirus saimiri (strain 11); JC polyomavirus; Human immunodeficiency virus 1; Human gammaherpesvirus 8; Human alphaherpesvirus 1; Human betaherpesvirus 5; human gammaherpesvirus 4; Human betaherpesvirus 6B; Betapolyomavirus macacae; Homo sapiens; Macacine alphaherpesvirus 1; Merkel cell polyomavirus; Human alphaherpesvirus 2; Betapolyomavirus hominis

Type:

Non-coding RNA profiling by array

Platform:

GPL21599

12 Samples

Download data: TXT, XLSX

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:

Homo sapiens; dengue virus type 4; Measles morbillivirus; Human immunodeficiency virus 1; Measles virus strain Schwarz

Type:

Expression profiling by high throughput sequencing

5 related Platforms

114 Samples

Download data: TXT

(Submitter supplied) Pattern recognition receptors (PRRs) protect against host invasion by detecting specific molecular patterns found in pathogens and initiating an immune response. While microbial-derived PRR ligands have been extensively characterized, the contribution and relevance of endogenous ligands to PRR activation during viral infection remain overlooked. In this work, we characterize the landscape of endogenous ligands that engage RIG-I-like receptors upon infection by a positive-sense RNA virus, a negative-sense RNA virus or a retrovirus. more...

Organism:

Homo sapiens; Human immunodeficiency virus 1

Type:

Expression profiling by high throughput sequencing

Platform:

GPL26693

24 Samples

Download data: TXT

(Submitter supplied) Characterization of pluripotent states, in which cells can both self-renew or differentiate, with the irreversible loss of pluripotency, are important research areas in developmental biology. Although microRNAs (miRNAs) have been shown to be crucial for embryonic stem (ES) self-renewal maintenance and cellular differentiation, the role of miRNAs integrated into gene regulatory networks and its dynamic changes during these state transitions remain elusive. more...

Organism:

Human alphaherpesvirus 2; Murid gammaherpesvirus 4; Mus musculus; Rattus norvegicus; Murid betaherpesvirus 1; JC polyomavirus; Human immunodeficiency virus 1; Merkel cell polyomavirus; Homo sapiens; Human alphaherpesvirus 1; Human betaherpesvirus 5; Betapolyomavirus hominis; human gammaherpesvirus 4; Human gammaherpesvirus 8; Betapolyomavirus macacae

Type:

Non-coding RNA profiling by array

Platform:

GPL18658

12 Samples

Download data: TXT

(Submitter supplied) MicroRNAs profile of circulating CD4+ T Cells in Aged Patients with Atherosclerosis Obliterans comparing healthy persons without symptoms or lesion associated with atherosclerosis.

Organism:

Homo sapiens; Rhadinovirus; Human immunodeficiency virus 1; Merkel cell polyomavirus; Human alphaherpesvirus 2; Lymphocryptovirus; JC polyomavirus

Type:

Non-coding RNA profiling by array

Platform:

GPL26002

14 Samples

Download data: GPR, XLSX

(Submitter supplied) We report deep mutational scanning data for the Env protein's LLP-2 domain in the NL4-3 strain HIV-1 Env. Processed Data repersents counts for each amino acid pre and post spread

Organism:

Human immunodeficiency virus 1

Type:

Other

Platform:

GPL23868

76 Samples

Download data: TAB

(Submitter supplied) Several prior reports have demonstrated that the epitranscriptomic addition of m6A to viral transcripts promotes the replication and pathogenicity of a wide range of viruses yet the underlying mechanism(s) causing this positive effect has remained unclear. It is known that m6A function is largely mediated by cellular m6A binding proteins or readers, however, how these m6A reader proteins contribute to the regulation of HIV-1 gene expression has remained controversial. more...

Organism:

Homo sapiens; Human immunodeficiency virus 1

Type:

Other

Platform:

GPL18160

3 Samples

Download data: BED

(Submitter supplied) Using the highly sensitive miRNA microarray, we screened 107 up-regulated microRNAs and 33 down-regulated microRNAs in the INT-HA-induced M2-like macrophages and we explored the functions of these miRNAs in macrophage polarization. The enrichment results indicated that these miRNAs might participate in the process of macrophage polarization. Furthermore, the quantitative real-time polymerase chain reaction results showed that miR-935 may play an important role in M2 macrophage polarization which was activated by INT-HA.

Organism:

Herpesvirus saimiri (strain 11); JC polyomavirus; Betapolyomavirus macacae; Homo sapiens; Betapolyomavirus hominis; Human alphaherpesvirus 2; Merkel cell polyomavirus; Human immunodeficiency virus 1; Human betaherpesvirus 6B

Type:

Non-coding RNA profiling by array

Platform:

GPL24594

6 Samples

Download data: GPR

(Submitter supplied) An improved mechanistic understanding of the thyroid hormone (TH) action on bile acid (BA) synthetic pathway, the major route for cholesterol elimination, will facilitate the identification of novel therapeutic targets for hypercholesterolemia. Here, we show that hepatic miR-378 is positively regulated by TH. Transient overexpression of miR-378 in the liver of mice reduces the serum cholesterol levels, which is accompanied with an upregulation of key enzymes involved in the intrahepatic conversion of cholesterol to BAs. more...

Organism:

Homo sapiens; Mus musculus; Human alphaherpesvirus 1; Human betaherpesvirus 5; Murid betaherpesvirus 1; Human immunodeficiency virus 1; Rattus norvegicus; Murid gammaherpesvirus 4; Betapolyomavirus hominis; human gammaherpesvirus 4; JC polyomavirus; Human gammaherpesvirus 8; Betapolyomavirus macacae

Type:

Non-coding RNA profiling by array

Platform:

GPL20794

1 Sample

Download data: TXT, XLS

(Submitter supplied) The potential mechanism were successfully illustrated through detecting different expression of microRNAs in between proinflammatory high density lipprotein (pHDL), nomal high density lipprotein (nHDL) and control group, to study whether microRNAs play important roles in the endothelial dysfunction caused by pHDL.

Organism:

JC polyomavirus; Human alphaherpesvirus 2; Lymphocryptovirus; Merkel cell polyomavirus; Homo sapiens; Rhadinovirus; Human immunodeficiency virus 1

Type:

Non-coding RNA profiling by array

Platform:

GPL29064

3 Samples

Download data: XLS

(Submitter supplied) The goal of this study was to determine how an HIV quasispecies is maintained in the face of selection. We deep sequenced the HIV provirus from cell populations as well as single cells at different time points from in vitro evolution experiments and found that when a less fit and more fit infect the same cell, they share components (complmentation) and therefore allow the less fit to perpetuate. We reproduced a quasispecies to an HIV reverse transcriptase inhibitor. more...

Organism:

Human immunodeficiency virus 1

Type:

Genome variation profiling by high throughput sequencing

Platform:

GPL23868

207 Samples

Download data: CSV

(Submitter supplied) The goal of this set of experiments is to determine the structure of HIV-1 NL4-3 and NHG RNA structure using a novel algorithm that allows for the identification of multiple RNA folding conformations. The input data used for this algorithm is DMS-MaPseq data. We focused on two specific areas of the HIV-1 genome, the Rev Response Element (RRE) and A3 splice acceptor site, as well as probing the whole HIV-1 genome. more...

Organism:

Human immunodeficiency virus 1; Homo sapiens; synthetic construct; Vibrio vulnificus

Type:

Other

7 related Platforms

23 Samples

Download data: TXT

(Submitter supplied) To explore the miRNAs associated with the memory deficits in Alzheimer's disease, we detected the miRNA profiles in the hippocampus of 6-month-old male APPswe/PS1dE9 (APP/PS1) mice and age-matched wild type C57BL/6 mice.

Organism:

human gammaherpesvirus 4; Herpesvirus saimiri (strain 11); JC polyomavirus; Human gammaherpesvirus 8; Betapolyomavirus macacae; Human alphaherpesvirus 2; Human betaherpesvirus 6B; Merkel cell polyomavirus; Betapolyomavirus hominis; Homo sapiens; Mus musculus; Human alphaherpesvirus 1; Macacine alphaherpesvirus 1; Human betaherpesvirus 5; Human immunodeficiency virus 1

Type:

Non-coding RNA profiling by array

Platform:

GPL21439

6 Samples

Download data: GPR

(Submitter supplied) The expression profile of miRNAs in soft palate muscle of patients with OSAHS (obstructive sleep apnea/hypopnea syndrome) and chronic tonsillitis was examined using miRNA microarray analysis. Combining with the following real time PCR and bioinformatics analysis, the physiological importance of the miRNA-autophagy interconnection is far more likely to be elucidated.

Organism:

Human alphaherpesvirus 2; JC polyomavirus; Betapolyomavirus hominis; Human alphaherpesvirus 1; Cytomegalovirus; Lymphocryptovirus; Betapolyomavirus macacae; Homo sapiens; Rhadinovirus; Human immunodeficiency virus 1; Merkel cell polyomavirus

Type:

Non-coding RNA profiling by array

Platform:

GPL19128

8 Samples

Download data: GPR, TXT