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Items: 1 to 20 of 646

1.

Targeting MYC Transcription with Small Peptide Derived from KSHV Transactivator

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.
Organism:
Homo sapiens; Human gammaherpesvirus 8
Type:
Genome binding/occupancy profiling by high throughput sequencing; Expression profiling by high throughput sequencing
Platforms:
GPL24676 GPL20301 GPL30065
53 Samples
Download data: BW, TSV
Series
Accession:
GSE173725
ID:
200173725
2.

Targeting MYC Transcription with Small Peptide Derived from KSHV Transactivator (CUT&RUN)

(Submitter supplied) Herpesviruses rely on host cell transcription and translation machineries for replication. Viral proteins thus function to redirect multiple cellular proteins for viral replication. In herpesvirus replicating cells, host cell gene transcription is frequently down-regulated because important transcriptional apparatuses are appropriated by viral transcription factors. Here we show that an evolutionally-shaped viral protein sequence is a great starting material for unique drug development to modulate cellular transcription. more...
Organism:
Human gammaherpesvirus 8; Homo sapiens
Type:
Genome binding/occupancy profiling by high throughput sequencing
Platform:
GPL30065
15 Samples
Download data: BW
Series
Accession:
GSE173724
ID:
200173724
3.

Differentially expressed microRNAs in the mouse liver with T3 treatment

(Submitter supplied) An improved mechanistic understanding of the thyroid hormone (TH) action on bile acid (BA) synthetic pathway, the major route for cholesterol elimination, will facilitate the identification of novel therapeutic targets for hypercholesterolemia. Here, we show that hepatic miR-378 is positively regulated by TH. Transient overexpression of miR-378 in the liver of mice reduces the serum cholesterol levels, which is accompanied with an upregulation of key enzymes involved in the intrahepatic conversion of cholesterol to BAs. more...
Organism:
Homo sapiens; Mus musculus; Human alphaherpesvirus 1; Human betaherpesvirus 5; Murid betaherpesvirus 1; Human gammaherpesvirus 4; Human immunodeficiency virus 1; Murid gammaherpesvirus 4; Human polyomavirus 1; JC polyomavirus; Human gammaherpesvirus 8; Macaca mulatta polyomavirus 1; Rattus norvegicus
Type:
Non-coding RNA profiling by array
Platform:
GPL20794
1 Sample
Download data: TXT, XLS
Series
Accession:
GSE139961
ID:
200139961
4.

Widespread traces of lytic KSHV in primary effusion lymphoma at single-cell resolution

(Submitter supplied) Cancer cells of primary effusion lymphoma (PEL) often contain both Kaposi sarcoma-associated herpesvirus (KSHV) and Epstein-Barr virus (EBV). We measured the interplay of human, KSHV, and EBV transcription in a cell culture model of PEL using single-cell RNA sequencing. The data detect widespread trace expression of lytic KSHV genes.
Organism:
Homo sapiens; Human gammaherpesvirus 4; Human gammaherpesvirus 8
Type:
Expression profiling by high throughput sequencing
Platform:
GPL28902
2 Samples
Download data: CSV
Series
Accession:
GSE154900
ID:
200154900
5.

miRNA profile in the hippocampus of APP/PS1 transgenic mice

(Submitter supplied) To explore the miRNAs associated with the memory deficits in Alzheimer's disease, we detected the miRNA profiles in the hippocampus of 6-month-old male APPswe/PS1dE9 (APP/PS1) mice and age-matched wild type C57BL/6 mice.
Organism:
Herpesvirus saimiri (strain 11); JC polyomavirus; Human gammaherpesvirus 8; Macaca mulatta polyomavirus 1; Human polyomavirus 1; Homo sapiens; Mus musculus; Human alphaherpesvirus 1; Macacine alphaherpesvirus 1; Human betaherpesvirus 5; Human gammaherpesvirus 4; Human immunodeficiency virus 1; Human alphaherpesvirus 2; Human betaherpesvirus 6B; Merkel cell polyomavirus
Type:
Non-coding RNA profiling by array
Platform:
GPL21439
6 Samples
Download data: GPR
Series
Accession:
GSE138382
ID:
200138382
6.

An integrative approach identifies direct targets of the late viral transcription complex and an expanded promoter recognition motif in Kaposi’s sarcoma-associated herpesvirus

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.
Organism:
Human gammaherpesvirus 8; Homo sapiens
Type:
Genome binding/occupancy profiling by high throughput sequencing; Expression profiling by high throughput sequencing
Platform:
GPL25719
17 Samples
Download data: TDF, TXT
Series
Accession:
GSE126603
ID:
200126603
7.

RNA sequencing analysis to identify gene targets of Kaposi's sarcoma herpesvirus (KSHV) ORF24

(Submitter supplied) ORF24 is the core component of a virally encoded transcription complex in KSHV that is active during later stages of infection. ORF24 makes interactions with both promoter DNA and host RNA polymerase II. The aim of this study was to identify the targets of the virally encoded transcription complex by sequencing total RNA from cells that express a mutant ORF24 that does not interact with RNA polymerase II and compare it to RNA from a mutant rescue cell line (WT). more...
Organism:
Homo sapiens; Human gammaherpesvirus 8
Type:
Expression profiling by high throughput sequencing
Platform:
GPL25719
9 Samples
Download data: TXT
Series
Accession:
GSE126602
ID:
200126602
8.

Genome-wide map of viral transcription factor ORF34 binding in Kaposi's Sarcoma Herpesvirus (KSHV)

(Submitter supplied) We report the mapping of the genome-wide binding sites of a central component of a viral transcription complex from KSHV. We find that ORF34 binds at several locations on the viral genome but observed no detectable binding to the host genome. A majority of binding sites on the viral genome were upstream of known transcription start sites of mapped genes.
Organism:
Human gammaherpesvirus 8; Homo sapiens
Type:
Genome binding/occupancy profiling by high throughput sequencing
Platform:
GPL25719
8 Samples
Download data: TDF
Series
Accession:
GSE126601
ID:
200126601
9.

microRNA responses of LPS and IL-10 stimulated primary human monocyte-derived macrophages over a short time-course

(Submitter supplied) Lipopolysaccharide stimulated primary human monocyte-derived macrophages at 2, 4 and 8hrs, IL-10 at 4hrs, IL-10+LPS at 4hrs
Organism:
Rattus norvegicus; Homo sapiens; Mus musculus; Human alphaherpesvirus 1; Human betaherpesvirus 5; Murid betaherpesvirus 1; Human gammaherpesvirus 4; Human immunodeficiency virus 1; JC polyomavirus; Human gammaherpesvirus 8; Macaca mulatta polyomavirus 1; Murid gammaherpesvirus 4; Human polyomavirus 1
Type:
Non-coding RNA profiling by array
Platform:
GPL7722
6 Samples
Download data: TXT
Series
Accession:
GSE125572
ID:
200125572
10.

Comparative Analysis of Gammaherpesvirus Circular RNA

(Submitter supplied) Recent studies have identified circular RNAs (circRNAs) expressed from the Epstein-Barr virus (EBV) and Kaposi’s sarcoma herpesvirus (KSHV) human DNA tu- mor viruses. To gain initial insights into the potential relevance of EBV circRNAs in virus biology and disease, we assessed the circRNAome of the interspecies homologue rhesus macaque lymphocryptovirus (rLCV) in a naturally occurring lymphoma from a simian immunodeficiency virus (SIV)-infected rhesus macaque. more...
Organism:
Macacine gammaherpesvirus 4; Human gammaherpesvirus 8; Homo sapiens; Mus musculus; Macaca mulatta; Murid herpesvirus 68
Type:
Other
Platforms:
GPL26009 GPL25719 GPL26010
10 Samples
Download data: BED
11.

RNA sequencing for KSHV circular RNAs

(Submitter supplied) The purpose was to detect viral circular RNAs from infected cells.
Organism:
Homo sapiens; Human gammaherpesvirus 8
Type:
Expression profiling by high throughput sequencing
Platform:
GPL25719
8 Samples
Download data: BED
Series
Accession:
GSE121756
ID:
200121756
12.

Quantitative RNAseq analysis of Ugandan KS tumors reveals KSHV gene expression dominated by transcription from the LTd downstream latency promoter

(Submitter supplied) Purpose: We used RNA deep sequencing to characterize KSHV expression in a large collection of KS biopsies (n=41) from HIV-infected Ugandans. Using a novel approach to quantitate expression in complex genomes like KSHV, we found that RNA from a single KSHV promoter within the latency region constituted the majority of KSHV transcripts in the KS tumors. Alternate RNA processing produced different spliced and un-spliced transcripts with different coding potentials. more...
Organism:
Human gammaherpesvirus 8
Type:
Expression profiling by high throughput sequencing
Platform:
GPL25233
41 Samples
Download data: GFF, TXT, XLS
Series
Accession:
GSE116160
ID:
200116160
13.

Microarray-based miRNA expression,identified miRNAs that were regulated by KSHV vIRF1

(Submitter supplied) HUVECs were transduced with lentiviral vIRF1 or control lentivirus (pHAGE),microarray-based miRNA expression profiling was adopted and identified a set of miRNAs that were differentially expressed between vIRF1- and pHAGE-transduced HUVECs
Organism:
Human alphaherpesvirus 1; Human betaherpesvirus 5; Human betaherpesvirus 6B; Macaca mulatta polyomavirus 1; Homo sapiens; Macacine alphaherpesvirus 1; Merkel cell polyomavirus; Human polyomavirus 1; Human alphaherpesvirus 2; Human gammaherpesvirus 4; Herpesvirus saimiri (strain 11); JC polyomavirus; Human immunodeficiency virus 1; Human gammaherpesvirus 8
Type:
Non-coding RNA profiling by array
Platforms:
GPL20712 GPL21439
6 Samples
Download data: TXT
Series
Accession:
GSE119034
ID:
200119034
14.

Kaposi’s Sarcoma-associated Herpesvirus Reactivation by Bacteria Promotes the Hypoxia Response and Epigenetic Regulation

(Submitter supplied) Herpesviruses are frequently co-present with bacterial infection at multiple sites within the body, including the mouth, gut, and genitourinary tract. The detection of replicating virus in these compartments prompted investigation into the relationship between bacterial infection and Kaposi’s Sarcoma-associated Herpesvirus (KSHV) reactivation. Using a cell line latently infected with KSHV, we examined the ability of crude spent media containing metabolic products from periodontal and gut pathogens to reactivate KSHV. more...
Organism:
Human alphaherpesvirus 1; Human alphaherpesvirus 2; Human alphaherpesvirus 3; Human betaherpesvirus 7; human papillomavirus 72; Human betaherpesvirus 6; Cucumber mosaic virus; Human gammaherpesvirus 8; Homo sapiens; Simian-Human immunodeficiency virus
Type:
Expression profiling by array
Platform:
GPL19981
7 Samples
Download data: GPR, TXT
Series
Accession:
GSE67532
ID:
200067532
15.

Mechanical stretch induced transcriptomic profiles in cardiac myocytes

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.
Organism:
Murid gammaherpesvirus 4; Human polyomavirus 1; JC polyomavirus; Human gammaherpesvirus 8; Macaca mulatta polyomavirus 1; Homo sapiens; Mus musculus; Human alphaherpesvirus 1; Human betaherpesvirus 5; Murid betaherpesvirus 1; Human gammaherpesvirus 4; Human immunodeficiency virus 1; Rattus norvegicus
Type:
Non-coding RNA profiling by array
Platform:
GPL7722
20 Samples
Download data
Series
Accession:
GSE107380
ID:
200107380
16.

Mechanical stretch induced transcriptomic profiles in cardiac myocytes [24-48 hours]

(Submitter supplied) The effect of cyclic mecanical stretch on cardiac microRNA expression was studied in neonatal rat ventricular myocytes (NRVMs).
Organism:
Rattus norvegicus; JC polyomavirus; Human gammaherpesvirus 8; Macaca mulatta polyomavirus 1; Homo sapiens; Mus musculus; Human alphaherpesvirus 1; Human betaherpesvirus 5; Murid betaherpesvirus 1; Human immunodeficiency virus 1; Human gammaherpesvirus 4; Murid gammaherpesvirus 4; Human polyomavirus 1
Type:
Non-coding RNA profiling by array
Platform:
GPL7722
9 Samples
Download data: XLS
Series
Accession:
GSE107379
ID:
200107379
17.

Mechanical stretch induced transcriptomic profiles in cardiac myocytes [1-12 hours]

(Submitter supplied) The effect of cyclic mecanical stretch on cardiac microRNA expression was studied in neonatal rat ventricular myocytes (NRVMs).
Organism:
Mus musculus; Human gammaherpesvirus 4; Human gammaherpesvirus 8; Human polyomavirus 1; Rattus norvegicus; JC polyomavirus; Murid gammaherpesvirus 4; Homo sapiens; Human betaherpesvirus 5; Murid betaherpesvirus 1; Human immunodeficiency virus 1; Human alphaherpesvirus 1; Macaca mulatta polyomavirus 1
Type:
Non-coding RNA profiling by array
Platform:
GPL7722
11 Samples
Download data: XLS
Series
Accession:
GSE107378
ID:
200107378
18.

MiR-106a increases granulosa cell viability and is down-regulated in women with diminished ovarian reserve

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.
Organism:
Human gammaherpesvirus 4; Human gammaherpesvirus 8; Human polyomavirus 1; Rattus norvegicus; JC polyomavirus; Murid gammaherpesvirus 4; Homo sapiens; Mus musculus; Human betaherpesvirus 5; Murid betaherpesvirus 1; Human immunodeficiency virus 1; Merkel cell polyomavirus; Human alphaherpesvirus 1; Human alphaherpesvirus 2; Mus musculus cytomegalovirus 2; Macaca mulatta polyomavirus 1
Type:
Non-coding RNA profiling by array
Platform:
GPL11434
12 Samples
Download data: GPR
Series
Accession:
GSE111774
ID:
200111774
19.

Differentially expressed miRNAs in serum of diminished ovarian reserve (DOR) patients

(Submitter supplied) To investigate the pathogenesis of diminished ovarian reserve, differentially expressed miRNAs in serum were constructed through miRCURYTM LNA expression Array.
Organism:
Human alphaherpesvirus 1; Human betaherpesvirus 5; Mus musculus cytomegalovirus 2; Macaca mulatta polyomavirus 1; Rattus norvegicus; Human alphaherpesvirus 2; JC polyomavirus; Murid gammaherpesvirus 4; Homo sapiens; Murid betaherpesvirus 1; Merkel cell polyomavirus; Human polyomavirus 1; Mus musculus; Human gammaherpesvirus 4; Human immunodeficiency virus 1; Human gammaherpesvirus 8
Type:
Non-coding RNA profiling by array
Platform:
GPL11434
6 Samples
Download data: GPR
Series
Accession:
GSE111773
ID:
200111773
20.

Differentially expressed miRNAs in granulosa cell of diminished ovarian reserve (DOR) patients

(Submitter supplied) To investigate the pathogenesis of diminished ovarian reserve, differentially expressed miRNAs in granulosa cells were constructed through miRCURYTM LNA expression Array.
Organism:
Homo sapiens; Human alphaherpesvirus 1; Human betaherpesvirus 5; Macaca mulatta polyomavirus 1; Rattus norvegicus; Human alphaherpesvirus 2; Murid gammaherpesvirus 4; Merkel cell polyomavirus; Mus musculus cytomegalovirus 2; Human polyomavirus 1; Mus musculus; Murid betaherpesvirus 1; Human gammaherpesvirus 4; JC polyomavirus; Human immunodeficiency virus 1; Human gammaherpesvirus 8
Type:
Non-coding RNA profiling by array
Platform:
GPL11434
6 Samples
Download data: GPR
Series
Accession:
GSE111771
ID:
200111771
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