GEO DataSets

(Submitter supplied) klf4 is enriched in a putative tegument associated lineage of S. mansoni. To investigate the function of klf4, we compared transcriptional profiles of klf4 (RNAi) worms to those of control (RNAi) worms.

Organism:

Schistosoma mansoni

Type:

Expression profiling by high throughput sequencing

Platform:

GPL28252

6 Samples

Download data: XLSX

(Submitter supplied) klf4 is enriched in a putative tegument associated lineage of S. mansoni. To characterize cellular and molecular changes associated with klf4 loss of function, we performed single-cell RNAseq on control (RNAi) and klf4 (RNAi) worms

Organism:

Schistosoma mansoni

Type:

Expression profiling by high throughput sequencing

Platform:

GPL24248

2 Samples

Download data: RDS

(Submitter supplied) Schistosomiasis affects over 250 million people worldwide and is caused by trematodes of the genus Schistosoma including the species Schistosoma mansoni. Praziquantel (PZQ) is the most widely available and implemented drug for this disease, and is produced as an racematic mixture composed of the enantiomers, R-PZQ and S-PZQ. In this study we examined the gene expression profiles of 49 day male S. mansoni after 18 hour treatment with R-PZQ, S-PZQ or control (1% DMSO). more...

Organism:

Schistosoma mansoni

Type:

Expression profiling by high throughput sequencing

Platform:

GPL24248

12 Samples

Download data: XLS

(Submitter supplied) Schistosoma mansoni is a flatworm that causes schistosomiasis, a neglected tropical disease that affects over 200 million people worldwide. New therapeutic targets are needed with only one drug available for treatment and no vaccine. Long non-coding RNAs (lncRNAs) are transcripts longer than 200 nucleotides with low or no protein-coding potential. In other organisms, they have been shown as involved with reproduction, stem cell maintenance and drug resistance, and they tend to exhibit tissue-specific expression patterns. more...

Organism:

Schistosoma mansoni

Type:

Expression profiling by high throughput sequencing; Third-party reanalysis

Download data: RDS, TXT

(Submitter supplied) The rhesus macaque provides a unique model of acquired immunity against schistosomes, which afflict >200 million people worldwide. By monitoring bloodstream levels of parasite-gut derived antigen, we show that from week 10 onwards an established infection with Schistosoma mansoni was cleared in an exponential manner, eliciting resistance to reinfection. Secondary challenge at week 42 demonstrated that protection was strong in all animals and complete in some. more...

Organism:

Schistosoma mansoni

Type:

Expression profiling by high throughput sequencing

Platform:

GPL30536

12 Samples

Download data: TXT

(Submitter supplied) βAlanyl-tryptamine (BATT) is a peptide secreted by male S. mansoni upon pairing with a female parasite. Treatment of synthetic BATT on virgin females wihtout any pairing is sufficient to induce sexual development and egg depostiion.

Organism:

Schistosoma mansoni

Type:

Expression profiling by high throughput sequencing

Platform:

GPL28252

6 Samples

Download data: CSV

(Submitter supplied) The schistosome homolog of ftz-f1 is a nuclear receptor. In order to understand the function of Smftz-f1, we performed RNAseq with samples taken on two days, Day 5 and Day 9, on either control (RNAi) or Smftz-f1 (RNAi) parasites to see the transcriptional consequences of Smftz-f1 RNAi and to find potential transcriptional targets.

Organism:

Schistosoma mansoni

Type:

Expression profiling by high throughput sequencing

Platform:

GPL28252

12 Samples

Download data: XLSX

(Submitter supplied) gli1 is a gene in the male S. mansoni required for female sexual development. As a putative transcription factor, RNAseq comparing pairs with gli1 knocked-down or control males was performed to look for the genes which are trancriptionally regulated by gli1. sm-nrps was one of the essential candidate discovered in this analysis that has been characterized in the same publication, revealing a pheromone directed novel mechanism of female schistosome sexual development.

Organism:

Schistosoma mansoni

Type:

Expression profiling by high throughput sequencing

Platform:

GPL28252

24 Samples

Download data: CSV

(Submitter supplied) To date, 115 miRNAs genes (precursors) have been registered in miRBase for Schistosoma mansoni, and 56 for Schistosoma japonicum (225 and 79 mature miRNA, respectively). miRNAs have not been systematically described in Schistosoma haematobium. Our aim in this study was to systematically characterize and quantify miRNA in Schistosoma by species, developmental stage and sex and to test the usefulness of this characterization in biomarker discovery for infection. more...

Organism:

Schistosoma mansoni; Schistosoma haematobium; Schistosoma japonicum

Type:

Non-coding RNA profiling by high throughput sequencing

Platforms:

GPL21570 GPL25265 GPL25263

60 Samples

Download data: TXT

(Submitter supplied) Schistosomes are parasitic flatworms that cause one of the most prevalent infectious diseases from which millions of people are currently suffering. Here, we construct a cell type atlas of juvenile schistosomes to capture germline stem cells (GSCs) in the course of de novo gonadal development.

Organism:

Schistosoma mansoni

Type:

Expression profiling by high throughput sequencing

Platform:

GPL26379

29 Samples

Download data: TSV, TXT

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:

Schistosoma mansoni

Type:

Expression profiling by high throughput sequencing

Platforms:

GPL24248 GPL28252

15 Samples

Download data

(Submitter supplied) In order to better understand the biology of adult schistosomes, we performed single-cell RNAseq on adult male, adult sexually-mature female, and adult virgin female parasites.

Organism:

Schistosoma mansoni

Type:

Expression profiling by high throughput sequencing

Platform:

GPL24248

9 Samples

Download data: RDS, XLSX

(Submitter supplied) The schistosome homolog of hnf4 is involved in parasite blood feeding and stem cell biology. In order to understand the function of hnf4, we performed RNAseq on either control(RNAi) or hnf4(RNAi) parasites to see the transcriptional consequences of hnf4 RNAi

Organism:

Schistosoma mansoni

Type:

Expression profiling by high throughput sequencing

Platform:

GPL28252

6 Samples

Download data: CSV

(Submitter supplied) stk25 and tao genes came out of an RNAi screen in the parasitic flatworm Schistosoma mansoni, and these genes shared a similar knockdown phenotype. To test for a functional relationship, we compared transcriptomes of early knockdown worms for each gene, compared to mock controls.

Organism:

Schistosoma mansoni

Type:

Expression profiling by high throughput sequencing

Platform:

GPL28252

12 Samples

Download data: XLSX

(Submitter supplied) Schistosomiasis is a chronic neglected tropical disease caused by digenetic parasitic flatworms of the genus Schistosoma. The disease is estimated to affect over 206 million people, the majority of whom live in Africa where Schistosoma mansoni and Schistosoma japonicum are the major causative agents. While a number of drugs have been used to treat schistosomiasis, praziquantel (PZQ) is the only one that is widely available, relatively cheap, and easy to use. more...

Organism:

Schistosoma mansoni

Type:

Expression profiling by high throughput sequencing

Platform:

GPL24248

24 Samples

Download data: XLSX

(Submitter supplied) The rise of single-cell RNA sequencing (scRNAseq) technologies has enabled researchers to classify cell types, delineate cell developmental trajectories, and measure molecular responses to external perturbations. These technologies all rely on the premise that cell-to-cell variations arising from the biological processes of interest are clearly distinguishable from the intrinsic transcriptional and technical noise. more...

Organism:

Schistosoma mansoni

Type:

Expression profiling by high throughput sequencing

Platforms:

GPL26379 GPL24248

737 Samples

Download data: CSV, FA, TXT

(Submitter supplied) We distrupted the expression of the Schistosoma mansoni zfp-1-1 gene using RNA interference and examined the transcriptional effects by illumina sequencing

Organism:

Schistosoma mansoni

Type:

Expression profiling by high throughput sequencing

Platform:

GPL24248

6 Samples

Download data: XLSX

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:

Schistosoma mansoni

Type:

Expression profiling by array

Platform:

GPL22001

18 Samples

Download data: TXT

(Submitter supplied) HDACs inhibitors induces mortality in the parasite Schistosoma mansoni (schistosomula and adult worms), and became an interesting drug class for the development of new drugs to treat schistosomiasis. In order to understand the effect of histone hyperacetylation on the parasite, we tested the effect of the HDAC inhibitor Trichostatin A on schistosomula gene expression.

Organism:

Schistosoma mansoni

Type:

Expression profiling by array

Platform:

GPL22001

6 Samples

Download data: TXT

(Submitter supplied) HDACs inhibitors induces mortality in the parasite Schistosoma mansoni (schistosomula and adult worms), and became an interesting drug class for the development of new drugs to treat schistosomiasis. In order to understand the effect of histone hyperacetylation on the parasite, we tested the effect of the HDAC inhibitor Trichostatin A on schistosomula gene expression.

Organism:

Schistosoma mansoni

Type:

Expression profiling by array

Platform:

GPL22001

6 Samples

Download data: TXT