GEO DataSets

(Submitter supplied) To examine innate immune signalling, IFN baseline and IRF-regulation, we profile Pteropus alecto bat kidney epithelial cells (PakiT03) with Deep NGS coverage. Clonal cell lines were also isolated with CrispR KO for IRF1, IRF3, IRF7, IFNAR2 or IFNAR2/IRF7 double KO.

Organism:

Pteropus alecto

Type:

Expression profiling by high throughput sequencing

Platform:

GPL26396

52 Samples

Download data: TXT

(Submitter supplied) To examine the fundamental immunity in bats, particularly the status of their innate immune system in the basal healthy state, we profile Pteropus alecto bat tissue with Deep NGS coverage. This is coupled to a paired experiment where bats were stimulated in vivo with various PRR ligands to activate immune pathways.

Organism:

Pteropus alecto

Type:

Expression profiling by high throughput sequencing

Platform:

GPL26396

13 Samples

Download data: TXT

(Submitter supplied) Bats are reservoirs of a number of highly pathogenic human viruses, yet they remain relatively asymptomatic during infection. Whether this viral resistance is due to a unique immune system is unknown. An evolutionarily conserved feature of vertebrate antiviral immunity is the interferon (IFN) response, which triggers cellular defenses through interferon-stimulated gene (ISG) expression. While bats encode an intact IFN system, global ISG expression patterns in bat cells are not well characterized. more...

Organism:

Pteropus alecto

Type:

Expression profiling by high throughput sequencing

Platform:

GPL23872

15 Samples

Download data: TXT

(Submitter supplied) Deep sequencing of mRNA from Pteropus alecto and Myotis davidii

Organism:

Pteropus alecto; Myotis davidii

Type:

Expression profiling by high throughput sequencing

Platforms:

GPL16126 GPL15898

2 Samples

Download data: FA, WIG