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septin7b septin 7b [ Danio rerio (zebrafish) ]

Gene ID: 100000597, updated on 25-Apr-2024

Summary

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Official Symbol
septin7bprovided by ZNC
Official Full Name
septin 7bprovided by ZNC
Primary source
ZFIN:ZDB-GENE-030131-37
See related
Ensembl:ENSDARG00000052673 AllianceGenome:ZFIN:ZDB-GENE-030131-37
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
sept7b; fj67f02; zeh0351; hm:zeh0351; wu:fj67f02
Summary
Predicted to enable GTPase activity and molecular adaptor activity. Acts upstream of or within defense response to bacterium. Predicted to be located in several cellular components, including cleavage furrow; kinetochore; and midbody. Predicted to be part of septin complex. Predicted to be active in cell division site; microtubule cytoskeleton; and septin ring. Orthologous to human SEPTIN7 (septin 7). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
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Genomic context

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See septin7b in Genome Data Viewer
Location:
chromosome: 16
Exon count:
15
Annotation release Status Assembly Chr Location
106 current GRCz11 (GCF_000002035.6) 16 NC_007127.7 (47390275..47426580, complement)
105 previous assembly GRCz10 (GCF_000002035.5) 16 NC_007127.6 (47455189..47491470, complement)

Chromosome 16 - NC_007127.7Genomic Context describing neighboring genes Neighboring gene si:dkey-256h2.1 Neighboring gene protachykinin-like Neighboring gene solute carrier family 25 member 32b Neighboring gene collagen triple helix repeat containing 1b

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. Sept7b is required for the subcellular organization of cardiomyocytes and cardiac function in zebrafish. Dash SN, et al. Am J Physiol Heart Circ Physiol, 2017 May 1. PMID 28341635
  2. Septins restrict inflammation and protect zebrafish larvae from Shigella infection. Mazon-Moya MJ, et al. PLoS Pathog, 2017 Jun. PMID 28650995, Free PMC Article
  3. The zebrafish as a new model for the in vivo study of Shigella flexneri interaction with phagocytes and bacterial autophagy. Mostowy S, et al. PLoS Pathog, 2013. PMID 24039575, Free PMC Article
  4. sept7b is required for the differentiation of pancreatic endocrine progenitors. Dash SN, et al. Sci Rep, 2016 Apr 26. PMID 27114183, Free PMC Article
  5. Evolutionary recruitment of flexible Esrp-dependent splicing programs into diverse embryonic morphogenetic processes. Burguera D, et al. Nat Commun, 2017 Nov 27. PMID 29180615, Free PMC Article

See all (12) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Study shows that sept7b expression is conserved in the developing vertebrate pancreas, and that the multipotent pancreatic progenitors of the larval zebrafish do not reach the mature state upon knockdown of sept7b. The data indicate that sept7b is essential for the specification and differentiation of the endocrine cell types and that sept7b affects endocrine differentiation by modulating the Notch-pathway.
    Title: sept7b is required for the differentiation of pancreatic endocrine progenitors.
  2. Knockdown of the zebrafish ortholog of human septin 7 (sept7b) destabilizes cardiac actin and reduces ventricular dimensions, contractility, and cardiac output in larval zebrafish, indicating that sept7b is essential for cardiac function. We further found that sept7b and retinoic acid signaling pathways converge to regulate cardiac function.
    Title: Sept7b is required for the subcellular organization of cardiomyocytes and cardiac function in zebrafish.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables GTP binding IEA
Inferred from Electronic Annotation
more info
  
enables GTPase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables molecular adaptor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within cell cycle IEA
Inferred from Electronic Annotation
more info
  
involved_in cilium assembly IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in cytoskeleton-dependent cytokinesis IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within defense response to bacterium IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in protein localization IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in cell division site IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in chromosome IEA
Inferred from Electronic Annotation
more info
  
located_in chromosome, centromeric region IEA
Inferred from Electronic Annotation
more info
  
located_in kinetochore IEA
Inferred from Electronic Annotation
more info
  
is_active_in microtubule cytoskeleton IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of septin complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of septin complex IEA
Inferred from Electronic Annotation
more info
  
is_active_in septin ring IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
septin 7b; septin-7

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001256029.1 → NP_001242958.1  septin 7b

    Status: PROVISIONAL

    Source sequence(s)
    BC097235
    UniProtKB/TrEMBL
    A0A8M1NZC4, Q4V8R9
    Conserved Domains (2) summary
    cd01850
    Location:26 → 296
    CDC_Septin; CDC/Septin GTPase family
    COG5019
    Location:8 → 374
    CDC3; Septin family protein [Cell cycle control, cell division, chromosome partitioning, Cytoskeleton]

RefSeqs of Annotated Genomes: Danio rerio Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007127.7 Reference GRCz11 Primary Assembly

    Range
    47390275..47426580 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005158466.4 → XP_005158523.1  septin-7 isoform X4

    UniProtKB/TrEMBL
    A0A8M2B4V3, Q4V8R9
    Conserved Domains (2) summary
    cd01850
    Location:27 → 297
    CDC_Septin; CDC/Septin GTPase family
    COG5019
    Location:9 → 375
    CDC3; Septin family protein [Cell cycle control, cell division, chromosome partitioning, Cytoskeleton]

  2. XM_009292676.3 → XP_009290951.1  septin-7 isoform X3

    UniProtKB/TrEMBL
    A0A8M3AJH4, Q4V8R9
    Conserved Domains (2) summary
    cd01850
    Location:27 → 297
    CDC_Septin; CDC/Septin GTPase family
    COG5019
    Location:9 → 375
    CDC3; Septin family protein [Cell cycle control, cell division, chromosome partitioning, Cytoskeleton]

  3. XM_005158469.4 → XP_005158526.1  septin-7 isoform X2

    UniProtKB/TrEMBL
    A0A8M2B5C8, Q4V8R9
    Conserved Domains (2) summary
    cd01850
    Location:27 → 297
    CDC_Septin; CDC/Septin GTPase family
    COG5019
    Location:9 → 382
    CDC3; Septin family protein [Cell cycle control, cell division, chromosome partitioning, Cytoskeleton]

  4. XM_009292679.3 → XP_009290954.1  septin-7 isoform X1

    UniProtKB/TrEMBL
    A0A8M3AR12, Q4V8R9
    Conserved Domains (2) summary
    cd01850
    Location:27 → 297
    CDC_Septin; CDC/Septin GTPase family
    COG5019
    Location:9 → 382
    CDC3; Septin family protein [Cell cycle control, cell division, chromosome partitioning, Cytoskeleton]

  5. XM_009292677.3 → XP_009290952.1  septin-7 isoform X5

    UniProtKB/TrEMBL
    A0A8M3ATV2
    Related
    ENSDARP00000069063.5, ENSDART00000074575.5
    Conserved Domains (2) summary
    cd01850
    Location:1 → 264
    CDC_Septin; CDC/Septin GTPase family
    COG5019
    Location:1 → 349
    CDC3; Septin family protein [Cell cycle control, cell division, chromosome partitioning, Cytoskeleton]

  6. XM_017351302.2 → XP_017206791.1  septin-7 isoform X6

    UniProtKB/TrEMBL
    A0A8M6Z1Q7, F8W5J3, Q4V8R9
    Related
    ENSDARP00000125075.1, ENSDART00000148631.3
Nucleotide Protein Strain
Heading Accession and Version

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