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cishb cytokine inducible SH2-containing protein b [ Danio rerio (zebrafish) ]

Gene ID: 100136861, updated on 27-Mar-2024

Summary

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Official Symbol
cishbprovided by ZNC
Official Full Name
cytokine inducible SH2-containing protein bprovided by ZNC
Primary source
ZFIN:ZDB-GENE-080204-120
See related
Ensembl:ENSDARG00000016773 AllianceGenome:ZFIN:ZDB-GENE-080204-120
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
socs8; cish.b; zgc:175109
Summary
Predicted to enable 1-phosphatidylinositol-3-kinase regulator activity. Predicted to be involved in phosphatidylinositol phosphate biosynthetic process. Predicted to act upstream of or within intracellular signal transduction; negative regulation of signal transduction; and regulation of growth. Predicted to be part of phosphatidylinositol 3-kinase complex. Human ortholog(s) of this gene implicated in malaria and tuberculosis. Orthologous to human CISH (cytokine inducible SH2 containing protein). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
all
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Genomic context

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See cishb in Genome Data Viewer
Location:
chromosome: 11
Exon count:
3
Annotation release Status Assembly Chr Location
106 current GRCz11 (GCF_000002035.6) 11 NC_007122.7 (17959488..17964533, complement)
105 previous assembly GRCz10 (GCF_000002035.5) 11 NC_007122.6 (17824853..17829898, complement)

Chromosome 11 - NC_007122.7Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC101886550 Neighboring gene uncharacterized LOC103911824 Neighboring gene twinfilin actin-binding protein 2b Neighboring gene RNA pseudouridine synthase D4

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. Long-term effects of ionizing radiation on gene expression in a zebrafish model. Jaafar L, et al. PLoS One, 2013. PMID 23936019, Free PMC Article
  2. Prolactin controls branchial clcn2c but not atp1a1a.2 in zebrafish Danio rerio. Breves JP. J Fish Biol, 2019 Jan. PMID 30367725
  3. Long non-coding RNAs have age-dependent diurnal expression that coincides with age-related changes in genome-wide facultative heterochromatin. Park J, et al. BMC Genomics, 2018 Oct 29. PMID 30373515, Free PMC Article
  4. Regulation of embryonic hematopoiesis by a cytokine-inducible SH2 domain homolog in zebrafish. Lewis RS, et al. J Immunol, 2014 Jun 15. PMID 24835394
  5. Global identification and comparative analysis of SOCS genes in fish: insights into the molecular evolution of SOCS family. Jin HJ, et al. Mol Immunol, 2008 Mar. PMID 18029016

See all (8) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables 1-phosphatidylinositol-3-kinase regulator activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within intracellular signal transduction IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within negative regulation of signal transduction IEA
Inferred from Electronic Annotation
more info
  
involved_in phosphatidylinositol phosphate biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein ubiquitination IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
part_of phosphatidylinositol 3-kinase complex IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
cytokine inducible SH2-containing protein b
Names
suppressor of cytokine signaling 8

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001114554.1 → NP_001108026.1  cytokine inducible SH2-containing protein b

    See identical proteins and their annotated locations for NP_001108026.1

    Status: PROVISIONAL

    Source sequence(s)
    EF195766
    UniProtKB/TrEMBL
    A9JRX2
    Conserved Domains (1) summary
    cd10718
    Location:42 → 129
    SH2_CIS; Src homology 2 (SH2) domain found in cytokine-inducible SH2-containing protein (CIS)

RefSeqs of Annotated Genomes: Danio rerio Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007122.7 Reference GRCz11 Primary Assembly

    Range
    17959488..17964533 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017358181.1 → XP_017213670.1  cytokine inducible SH2-containing protein b isoform X1

    UniProtKB/TrEMBL
    A0A8M6Z1L6, L0N8L8
    Related
    ENSDARP00000017764.6, ENSDART00000018948.9
    Conserved Domains (1) summary
    cd10718
    Location:51 → 138
    SH2_CIS; Src homology 2 (SH2) domain found in cytokine-inducible SH2-containing protein (CIS)

Reference GRCz11 ALT_DRER_TU_1

Genomic

  1. NW_018394813.1 Reference GRCz11 ALT_DRER_TU_1

    Range
    341176..346447 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version

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