U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

muc5.1 mucin 5.1, oligomeric mucus/gel-forming [ Danio rerio (zebrafish) ]

Gene ID: 100148804, updated on 27-Mar-2024

Summary

Go to the top of the page Help
Official Symbol
muc5.1provided by ZNC
Official Full Name
mucin 5.1, oligomeric mucus/gel-formingprovided by ZNC
Primary source
ZFIN:ZDB-GENE-120822-1
See related
Ensembl:ENSDARG00000070331 AllianceGenome:ZFIN:ZDB-GENE-120822-1
Gene type
protein coding
RefSeq status
MODEL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
muc5ac
Summary
Predicted to enable peptidase inhibitor activity. Predicted to be located in extracellular region. Predicted to be active in extracellular matrix and extracellular space. Is expressed in esophagus; gill lamella; intestine; and pharynx. [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
See muc5.1 in Genome Data Viewer
Location:
chromosome: 25
Exon count:
46
Annotation release Status Assembly Chr Location
106 current GRCz11 (GCF_000002035.6) 25 NC_007136.7 (8356838..8400124)
105 previous assembly GRCz10 (GCF_000002035.5) 25 NC_007136.6 (8279772..8323056)

Chromosome 25 - NC_007136.7Genomic Context describing neighboring genes Neighboring gene mucin-2-like Neighboring gene intestinal mucin-like protein Neighboring gene intestinal mucin-like protein Neighboring gene mucin 5.2 Neighboring gene mucin-2-like

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help
  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. Searching the Evolutionary Origin of Epithelial Mucus Protein Components-Mucins and FCGBP. Lang T, et al. Mol Biol Evol, 2016 Aug. PMID 27189557, Free PMC Article
  2. Zebrafish as a model to study live mucus physiology. Jevtov I, et al. Sci Rep, 2014 Oct 17. PMID 25323747, Free PMC Article
  3. Retinoic acid suppresses intestinal mucus production and exacerbates experimental enterocolitis. Oehlers SH, et al. Dis Model Mech, 2012 Jul. PMID 22563081, Free PMC Article
  4. Metagenomics analysis of gut microbiota and immune modulation in zebrafish (Danio rerio) fed chitosan silver nanocomposites. Udayangani RMC, et al. Fish Shellfish Immunol, 2017 Jul. PMID 28479399
  5. Gel-forming mucins appeared early in metazoan evolution. Lang T, et al. Proc Natl Acad Sci U S A, 2007 Oct 9. PMID 17911254, Free PMC Article

See all (10) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

Go to the top of the page Help

Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables peptidase inhibitor activity IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in extracellular matrix IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
  
is_active_in extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

Go to the top of the page Help
Preferred Names
mucin-2
Names
muc
muc5c
muc5l
mucin 5AC, oligomeric mucus/gel-forming

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs of Annotated Genomes: Danio rerio Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007136.7 Reference GRCz11 Primary Assembly

    Range
    8356838..8400124
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_021470622.1 → XP_021326297.1  mucin-2 isoform X1

    UniProtKB/TrEMBL
    A0A8M9P6P6, X1WBL9
    Related
    ENSDARP00000127611.1, ENSDART00000153708.3
    Conserved Domains (8) summary
    smart00041
    Location:5198 → 5274
    CT; C-terminal cystine knot-like domain (CTCK)
    smart00216
    Location:867 → 1025
    VWD; von Willebrand factor (vWF) type D domain
    smart00832
    Location:1063 → 1135
    C8; This domain contains 8 conserved cysteine residues
    pfam05375
    Location:848 → 874
    Pacifastin_I; Pacifastin inhibitor (LCMII)
    pfam00094
    Location:420 → 571
    VWD; von Willebrand factor type D domain
    pfam01826
    Location:324 → 380
    TIL; Trypsin Inhibitor like cysteine rich domain
    pfam08742
    Location:4818 → 4880
    C8; C8 domain
    pfam13330
    Location:1386 → 1476
    Mucin2_WxxW; Mucin-2 protein WxxW repeating region

  2. XM_021470624.1 → XP_021326299.1  mucin-2 isoform X3

    UniProtKB/TrEMBL
    A0A8M9PN30
    Conserved Domains (9) summary
    smart00041
    Location:4130 → 4206
    CT; C-terminal cystine knot-like domain (CTCK)
    smart00216
    Location:867 → 1025
    VWD; von Willebrand factor (vWF) type D domain
    smart00832
    Location:1063 → 1135
    C8; This domain contains 8 conserved cysteine residues
    pfam05375
    Location:848 → 874
    Pacifastin_I; Pacifastin inhibitor (LCMII)
    pfam00094
    Location:420 → 571
    VWD; von Willebrand factor type D domain
    pfam01826
    Location:324 → 380
    TIL; Trypsin Inhibitor like cysteine rich domain
    pfam08742
    Location:3750 → 3812
    C8; C8 domain
    pfam13330
    Location:1386 → 1476
    Mucin2_WxxW; Mucin-2 protein WxxW repeating region
    cl17735
    Location:3982 → 4045
    VWC; von Willebrand factor type C domain

  3. XM_021470623.1 → XP_021326298.1  mucin-2 isoform X2

    UniProtKB/TrEMBL
    A0A8M9PH65
    Conserved Domains (8) summary
    smart00041
    Location:5036 → 5112
    CT; C-terminal cystine knot-like domain (CTCK)
    smart00216
    Location:867 → 1025
    VWD; von Willebrand factor (vWF) type D domain
    smart00832
    Location:1063 → 1135
    C8; This domain contains 8 conserved cysteine residues
    pfam05375
    Location:848 → 874
    Pacifastin_I; Pacifastin inhibitor (LCMII)
    pfam00094
    Location:420 → 571
    VWD; von Willebrand factor type D domain
    pfam01826
    Location:324 → 380
    TIL; Trypsin Inhibitor like cysteine rich domain
    pfam08742
    Location:4656 → 4718
    C8; C8 domain
    pfam13330
    Location:1386 → 1476
    Mucin2_WxxW; Mucin-2 protein WxxW repeating region
Nucleotide Protein Strain
Heading Accession and Version

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Molecular Biology Databases
Tools
Miscellaneous