U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Islr2 immunoglobulin superfamily containing leucine-rich repeat 2 [ Rattus norvegicus (Norway rat) ]

Gene ID: 100910729, updated on 3-Apr-2024

Summary

Go to the top of the page Help
Official Symbol
Islr2provided by RGD
Official Full Name
immunoglobulin superfamily containing leucine-rich repeat 2provided by RGD
Primary source
RGD:6497037
See related
Ensembl:ENSRNOG00000050714 AllianceGenome:RGD:6497037
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to be involved in positive regulation of axon extension. Predicted to be integral component of membrane. Predicted to be active in cell surface. Orthologous to human ISLR2 (immunoglobulin superfamily containing leucine rich repeat 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Brain (RPKM 20.6), Testes (RPKM 5.2) and 7 other tissues See more
Orthologs
human mouse all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
See Islr2 in Genome Data Viewer
Location:
8q24
Exon count:
6
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 8 NC_086026.1 (67504042..67512125, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 8 NC_051343.1 (58608165..58616246, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 8 NC_005107.4 (62983333..62991401, complement)

Chromosome 8 - NC_086026.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC120094173 Neighboring gene signaling receptor and transporter of retinol STRA6 Neighboring gene immunoglobulin superfamily containing leucine-rich repeat Neighboring gene uncharacterized LOC134480059 Neighboring gene PML nuclear body scaffold

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help
  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. LIG family receptor tyrosine kinase-associated proteins modulate growth factor signals during neural development. Mandai K, et al. Neuron, 2009 Sep 10. PMID 19755105, Free PMC Article
  2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

Go to the top of the page Help

Markers

Homology

Gene Ontology Provided by RGD

Process Evidence Code Pubs
involved_in positive regulation of axon extension IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of axon extension ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
is_active_in cell surface IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cell surface ISO
Inferred from Sequence Orthology
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

Go to the top of the page Help
Preferred Names
immunoglobulin superfamily containing leucine-rich repeat protein 2
Names
immunoglobulin superfamily containing leucine-rich repeat protein 2-like

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001399427.1 → NP_001386356.1  immunoglobulin superfamily containing leucine-rich repeat protein 2 precursor

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000008
    UniProtKB/TrEMBL
    M0R4G0
    Conserved Domains (5) summary
    TIGR00864
    Location:155 → 229
    PCC; polycystin cation channel protein
    sd00033
    Location:37 → 53
    LRR_RI; leucine-rich repeat [structural motif]
    pfam13855
    Location:100 → 160
    LRR_8; Leucine rich repeat
    cd00096
    Location:257 → 264
    Ig; Ig strand B [structural motif]
    cl11960
    Location:249 → 374
    Ig; Immunoglobulin domain

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086026.1 Reference GRCr8

    Range
    67504042..67512125 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039082410.2 → XP_038938338.1  immunoglobulin superfamily containing leucine-rich repeat protein 2 isoform X1

    UniProtKB/TrEMBL
    A6J4Z5, M0R4G0
    Conserved Domains (5) summary
    TIGR00864
    Location:155 → 229
    PCC; polycystin cation channel protein
    sd00033
    Location:37 → 53
    LRR_RI; leucine-rich repeat [structural motif]
    pfam13855
    Location:100 → 160
    LRR_8; Leucine rich repeat
    cd00096
    Location:257 → 264
    Ig; Ig strand B [structural motif]
    cl11960
    Location:249 → 374
    Ig; Immunoglobulin domain

  2. XM_008766373.4 → XP_008764595.1  immunoglobulin superfamily containing leucine-rich repeat protein 2 isoform X1

    See identical proteins and their annotated locations for XP_008764595.1

    UniProtKB/TrEMBL
    A6J4Z5, M0R4G0
    Conserved Domains (5) summary
    TIGR00864
    Location:155 → 229
    PCC; polycystin cation channel protein
    sd00033
    Location:37 → 53
    LRR_RI; leucine-rich repeat [structural motif]
    pfam13855
    Location:100 → 160
    LRR_8; Leucine rich repeat
    cd00096
    Location:257 → 264
    Ig; Ig strand B [structural motif]
    cl11960
    Location:249 → 374
    Ig; Immunoglobulin domain

  3. XM_063264716.1 → XP_063120786.1  immunoglobulin superfamily containing leucine-rich repeat protein 2 isoform X1

    UniProtKB/TrEMBL
    M0R4G0

  4. XM_039082409.2 → XP_038938337.1  immunoglobulin superfamily containing leucine-rich repeat protein 2 isoform X1

    UniProtKB/TrEMBL
    A6J4Z5, M0R4G0
    Conserved Domains (5) summary
    TIGR00864
    Location:155 → 229
    PCC; polycystin cation channel protein
    sd00033
    Location:37 → 53
    LRR_RI; leucine-rich repeat [structural motif]
    pfam13855
    Location:100 → 160
    LRR_8; Leucine rich repeat
    cd00096
    Location:257 → 264
    Ig; Ig strand B [structural motif]
    cl11960
    Location:249 → 374
    Ig; Immunoglobulin domain

  5. XM_039082404.2 → XP_038938332.1  immunoglobulin superfamily containing leucine-rich repeat protein 2 isoform X1

    UniProtKB/TrEMBL
    A6J4Z5, M0R4G0
    Related
    ENSRNOP00000064244.2
    Conserved Domains (5) summary
    TIGR00864
    Location:155 → 229
    PCC; polycystin cation channel protein
    sd00033
    Location:37 → 53
    LRR_RI; leucine-rich repeat [structural motif]
    pfam13855
    Location:100 → 160
    LRR_8; Leucine rich repeat
    cd00096
    Location:257 → 264
    Ig; Ig strand B [structural motif]
    cl11960
    Location:249 → 374
    Ig; Immunoglobulin domain

  6. XM_006243178.5 → XP_006243240.1  immunoglobulin superfamily containing leucine-rich repeat protein 2 isoform X1

    See identical proteins and their annotated locations for XP_006243240.1

    UniProtKB/TrEMBL
    A6J4Z5, M0R4G0
    Conserved Domains (5) summary
    TIGR00864
    Location:155 → 229
    PCC; polycystin cation channel protein
    sd00033
    Location:37 → 53
    LRR_RI; leucine-rich repeat [structural motif]
    pfam13855
    Location:100 → 160
    LRR_8; Leucine rich repeat
    cd00096
    Location:257 → 264
    Ig; Ig strand B [structural motif]
    cl11960
    Location:249 → 374
    Ig; Immunoglobulin domain

  7. XM_039082405.1 → XP_038938333.1  immunoglobulin superfamily containing leucine-rich repeat protein 2 isoform X1

    UniProtKB/TrEMBL
    A6J4Z5, M0R4G0
    Conserved Domains (5) summary
    TIGR00864
    Location:155 → 229
    PCC; polycystin cation channel protein
    sd00033
    Location:37 → 53
    LRR_RI; leucine-rich repeat [structural motif]
    pfam13855
    Location:100 → 160
    LRR_8; Leucine rich repeat
    cd00096
    Location:257 → 264
    Ig; Ig strand B [structural motif]
    cl11960
    Location:249 → 374
    Ig; Immunoglobulin domain

  8. XM_017596042.3 → XP_017451531.1  immunoglobulin superfamily containing leucine-rich repeat protein 2 isoform X1

    UniProtKB/TrEMBL
    A6J4Z5, M0R4G0
    Conserved Domains (5) summary
    TIGR00864
    Location:155 → 229
    PCC; polycystin cation channel protein
    sd00033
    Location:37 → 53
    LRR_RI; leucine-rich repeat [structural motif]
    pfam13855
    Location:100 → 160
    LRR_8; Leucine rich repeat
    cd00096
    Location:257 → 264
    Ig; Ig strand B [structural motif]
    cl11960
    Location:249 → 374
    Ig; Immunoglobulin domain

  9. XM_039082403.2 → XP_038938331.1  immunoglobulin superfamily containing leucine-rich repeat protein 2 isoform X1

    UniProtKB/TrEMBL
    A6J4Z5, M0R4G0
    Conserved Domains (5) summary
    TIGR00864
    Location:155 → 229
    PCC; polycystin cation channel protein
    sd00033
    Location:37 → 53
    LRR_RI; leucine-rich repeat [structural motif]
    pfam13855
    Location:100 → 160
    LRR_8; Leucine rich repeat
    cd00096
    Location:257 → 264
    Ig; Ig strand B [structural motif]
    cl11960
    Location:249 → 374
    Ig; Immunoglobulin domain

  10. XM_039082408.2 → XP_038938336.1  immunoglobulin superfamily containing leucine-rich repeat protein 2 isoform X1

    UniProtKB/TrEMBL
    A6J4Z5, M0R4G0
    Conserved Domains (5) summary
    TIGR00864
    Location:155 → 229
    PCC; polycystin cation channel protein
    sd00033
    Location:37 → 53
    LRR_RI; leucine-rich repeat [structural motif]
    pfam13855
    Location:100 → 160
    LRR_8; Leucine rich repeat
    cd00096
    Location:257 → 264
    Ig; Ig strand B [structural motif]
    cl11960
    Location:249 → 374
    Ig; Immunoglobulin domain
Nucleotide Protein Strain
Heading Accession and Version

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
Molecular Biology Databases
Research Materials
Tools
Miscellaneous