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Zfp446 zinc finger protein 446 [ Rattus norvegicus (Norway rat) ]

Gene ID: 102552463, updated on 6-Jun-2024

Summary

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Symbol
Zfp446provided by RGD
Full Name
zinc finger protein 446provided by RGD
Primary source
RGD:7612453
See related
Ensembl:ENSRNOG00000060429 AllianceGenome:RGD:7612453
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
AABR07002065.2
Summary
Predicted to enable identical protein binding activity. Orthologous to human ZNF446 (zinc finger protein 446). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Liver (RPKM 54.0), Kidney (RPKM 35.4) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Zfp446 in Genome Data Viewer
Location:
1q21
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (82673920..82680414)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (73594953..73612685)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (65595518..65608757, complement)

Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC134482889 Neighboring gene zinc finger protein 324 Neighboring gene solute carrier family 27 member 5 Neighboring gene small nuclear ribonucleoprotein F-like Neighboring gene uncharacterized LOC108348449

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Comparison of tear protein levels in breast cancer patients and healthy controls using a de novo proteomic approach. Böhm D, et al. Oncol Rep, 2012 Aug. PMID 22664934, Free PMC Article
  2. A proteome-scale map of the human interactome network. Rolland T, et al. Cell, 2014 Nov 20. PMID 25416956, Free PMC Article
  3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables DNA binding IEA
Inferred from Electronic Annotation
more info
  
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in regulation of DNA-templated transcription IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
zinc finger protein 446

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001427845.1 → NP_001414774.1  zinc finger protein 446

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000001
    UniProtKB/TrEMBL
    A0A8I5ZPP3, A0A8I6ALX6, A6KQM3

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086019.1 Reference GRCr8

    Range
    82673920..82680414
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017589934.3 → XP_017445423.1  zinc finger protein 446 isoform X1

    UniProtKB/TrEMBL
    A0A8I5ZPP3, A0A8I6ALX6, A6KQM3
    Related
    ENSRNOP00000080472.1
    Conserved Domains (4) summary
    smart00431
    Location:22 → 126
    SCAN; leucine rich region
    sd00017
    Location:323 → 343
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam01352
    Location:213 → 239
    KRAB; KRAB box
    pfam02023
    Location:22 → 110
    SCAN; SCAN domain

  2. XM_063286215.1 → XP_063142285.1  zinc finger protein 446 isoform X3

    UniProtKB/TrEMBL
    D4A2E8

  3. XM_017589936.3 → XP_017445425.1  zinc finger protein 446 isoform X1

    UniProtKB/TrEMBL
    A0A8I5ZPP3, A0A8I6ALX6, A6KQM3
    Conserved Domains (4) summary
    smart00431
    Location:22 → 126
    SCAN; leucine rich region
    sd00017
    Location:323 → 343
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam01352
    Location:213 → 239
    KRAB; KRAB box
    pfam02023
    Location:22 → 110
    SCAN; SCAN domain

  4. XM_039100802.2 → XP_038956730.1  zinc finger protein 446 isoform X2

    UniProtKB/TrEMBL
    D4A2E8
    Conserved Domains (2) summary
    cd07765
    Location:213 → 240
    KRAB_A-box; KRAB (Kruppel-associated box) domain -A box
    pfam02023
    Location:22 → 108
    SCAN; SCAN domain
Nucleotide Protein Strain
Heading Accession and Version

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