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LOC107882129 EDNRB proximal promoter region [ Homo sapiens (human) ]

Gene ID: 107882129, updated on 10-Oct-2023

Summary

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Gene symbol
LOC107882129
Gene description
EDNRB proximal promoter region
Gene type
biological region
Feature type(s)
protein_bind
regulatory: promoter, transcriptional_cis_regulatory_region
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
This region represents the proximal promoter of the endothelin receptor type B gene. This promoter is positively regulated by binding of SRY-box 10 and AP-1 transcription factors, and may be negatively regulated by peroxisome proliferator-activated receptor-gamma. This region was observed to be hypermethylated and epigenetically silenced in tumor cells. [provided by RefSeq, May 2016]
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Genomic context

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Location:
chromosome: 13
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 13 NC_000013.11 (77918760..77919832)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 13 NC_060937.1 (77143687..77144759)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 13 NC_000013.10 (78492895..78493967)

Chromosome 13 - NC_000013.11Genomic Context describing neighboring genes Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 5421 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 5422 Neighboring gene microRNA 3665 Neighboring gene SLAIN motif family member 1 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 7846 Neighboring gene NANOG hESC enhancer GRCh37_chr13:78358462-78359034 Neighboring gene EDNRB antisense RNA 1 Neighboring gene VISTA enhancer hs1394 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr13:78425667-78426299 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr13:78427507-78428016 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr13:78428017-78428526 Neighboring gene endothelin receptor type B Neighboring gene RNA, 7SL, cytoplasmic 810, pseudogene Neighboring gene EDNRB upstream promoter region Neighboring gene long intergenic non-protein coding RNA 1069

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Low expression of endothelin receptor B (EDNRB) is related to H3K9me3 binding with the EDNRB promoter region and is associated with the clinical T tumor stage in salivary adenoid cystic carcinoma. Xia RH, et al. Oral Surg Oral Med Oral Pathol Oral Radiol, 2015 Aug. PMID 26166030
  2. SOX10, in combination with Sp1, regulates the endothelin receptor type B gene in human melanocyte lineage cells. Yokoyama S, et al. FEBS J, 2006 Apr. PMID 16623715
  3. Endothelin B receptor gene hypermethylation in prostate adenocarcinoma. Jerónimo C, et al. J Clin Pathol, 2003 Jan. PMID 12499435, Free PMC Article
  4. The endothelin receptor B (EDNRB) promoter displays heterogeneous, site specific methylation patterns in normal and tumor cells. Pao MM, et al. Hum Mol Genet, 2001 Apr 15. PMID 11309363
  5. Methylation of the 5' CpG island of the endothelin B receptor gene is common in human prostate cancer. Nelson JB, et al. Cancer Res, 1997 Jan 1. PMID 8988036

See all (14) citations in PubMed

GeneRIFs: Gene References Into Functions

Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See Variation Viewer (GRCh37.p13)

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_047194.1 

    Range
    101..1173
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000013.11 Reference GRCh38.p14 Primary Assembly

    Range
    77918760..77919832
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060937.1 Alternate T2T-CHM13v2.0

    Range
    77143687..77144759
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    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version

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