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ZNF765-ZNF761 ZNF765-ZNF761 readthrough [ Homo sapiens (human) ]

Gene ID: 110116772, updated on 23-Nov-2023

Summary

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Gene symbol
ZNF765-ZNF761
Gene description
ZNF765-ZNF761 readthrough
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
This locus represents naturally occurring readthrough transcription between the neighboring zinc finger protein 765 (ZNF765) and zinc finger protein 761 (ZNF761) genes. The readthrough transcript can encode a protein identical to the product of the ZNF761 gene. [provided by RefSeq, Apr 2017]
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Genomic context

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Location:
19q13.42
Exon count:
13
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 19 NC_000019.10 (53395149..53458261)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 19 NC_060943.1 (56474647..56537815)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (53898402..53961515)

Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene zinc finger protein 845 Neighboring gene putative zinc finger protein 137 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 11007 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 15066 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 11008 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:53872557-53873058 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:53873059-53873558 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr19:53877455-53878025 Neighboring gene zinc finger protein 525 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 11009 Neighboring gene ribosomal protein L39 pseudogene 35 Neighboring gene zinc finger protein 765 Neighboring gene putative zinc finger protein 137 Neighboring gene ribosomal protein L39 pseudogene 36 Neighboring gene vomeronasal 1 receptor 101 pseudogene Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 11010 Neighboring gene Sharpr-MPRA regulatory region 10215 Neighboring gene tropomyosin 3 pseudogene 9 Neighboring gene zinc finger protein 761 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 11011 Neighboring gene H3K27ac hESC enhancer GRCh37_chr19:53971207-53971768 Neighboring gene H3K27ac hESC enhancer GRCh37_chr19:53971769-53972331 Neighboring gene vomeronasal 1 receptor 102 pseudogene Neighboring gene zinc finger protein 813 Neighboring gene tropomyosin 3 pseudogene 6

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. The DNA sequence and biology of human chromosome 19. Grimwood J, et al. Nature, 2004 Apr 1. PMID 15057824
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. Ota T, et al. Nat Genet, 2004 Jan. PMID 14702039
  3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

Genotypes

General gene information

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Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
zinc finger protein 761

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001350496.2 → NP_001337425.1  zinc finger protein 761

    Status: VALIDATED

    Source sequence(s)
    AC022137, KF495723
    UniProtKB/Swiss-Prot
    A0A087WXT7, Q6ZNB9, Q86XN6
    Conserved Domains (4) summary
    COG5048
    Location:242 → 617
    COG5048; FOG: Zn-finger [General function prediction only]
    COG5189
    Location:651 → 737
    SFP1; Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning]
    sd00017
    Location:328 → 348
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam01352
    Location:7 → 48
    KRAB; KRAB box

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000019.10 Reference GRCh38.p14 Primary Assembly

    Range
    53395149..53458261
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060943.1 Alternate T2T-CHM13v2.0

    Range
    56474647..56537815
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q86XN6.3 GenPept UniProtKB/Swiss-Prot:Q86XN6

Gene LinkOut

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Molecular Biology Databases