ugdh UDP-glucose 6-dehydrogenase [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: ugdhprovided by ZNC
Official Full Name: UDP-glucose 6-dehydrogenaseprovided by ZNC
Primary source: ZFIN:ZDB-GENE-011022-1
See related: Ensembl:ENSDARG00000019838 AllianceGenome:ZFIN:ZDB-GENE-011022-1
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: sb:eu659; tdsubc_2a8; ik:tdsubc_2a8; xx:tdsubc_2a8
Summary: Predicted to enable NAD binding activity and UDP-glucose 6-dehydrogenase activity. Acts upstream of or within atrioventricular valve formation; determination of left/right symmetry; and positive regulation of signal transduction. Predicted to be active in cytosol and nucleus. Is expressed in several structures, including axis; head; heart tube; mesoderm; and vestibuloauditory system. Human ortholog(s) of this gene implicated in developmental and epileptic encephalopathy 84. Orthologous to human UGDH (UDP-glucose 6-dehydrogenase). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 1

Exon count:: 12

Annotation release	Status	Assembly	Chr	Location
106	current	GRCz11 (GCF_000002035.6)	1	NC_007112.7 (23283537..23294382, complement)
105	previous assembly	GRCz10 (GCF_000002035.5)	1	NC_007112.6 (22592798..22603643, complement)

Chromosome 1 - NC_007112.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables NAD binding	IEA Inferred from Electronic Annotation more info
enables UDP-glucose 6-dehydrogenase activity	IEA Inferred from Electronic Annotation more info
enables catalytic activity	IEA Inferred from Electronic Annotation more info
enables oxidoreductase activity	IEA Inferred from Electronic Annotation more info
enables oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in UDP-glucuronate biosynthetic process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within atrioventricular valve formation	IMP Inferred from Mutant Phenotype more info
acts_upstream_of_or_within determination of left/right symmetry	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in glycosaminoglycan biosynthetic process	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within heart development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within heart valve formation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within metabolic process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within positive regulation of canonical Wnt signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within positive regulation of smoothened signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: UDP-glucose 6-dehydrogenase

Names: UDP-glucose dehydrogenase; jek; jekyll

NP_001103872.1

EC 1.1.1.22

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001110402.1 → NP_001103872.1 UDP-glucose 6-dehydrogenase

See identical proteins and their annotated locations for NP_001103872.1

Status: PROVISIONAL

Source sequence(s)

BC154794

UniProtKB/TrEMBL

A0A8M1NEP4, A8WGP7

Related

ENSDARP00000004687.7, ENSDART00000013263.9

Conserved Domains (4) summary

PLN02353
Location:4 → 466

PLN02353; probable UDP-glucose 6-dehydrogenase

pfam00984
Location:214 → 309

UDPG_MGDP_dh; UDP-glucose/GDP-mannose dehydrogenase family, central domain

pfam03720
Location:332 → 449

UDPG_MGDP_dh_C; UDP-glucose/GDP-mannose dehydrogenase family, UDP binding domain

pfam03721
Location:6 → 193

UDPG_MGDP_dh_N; UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain