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LOC126862272 BRD4-independent group 4 enhancer GRCh37_chr16:5692155-5693354 [ Homo sapiens (human) ]

Gene ID: 126862272, updated on 10-Oct-2023

Summary

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Gene symbol
LOC126862272
Gene description
BRD4-independent group 4 enhancer GRCh37_chr16:5692155-5693354
Gene type
biological region
Feature type(s)
regulatory: enhancer
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
This genomic region was validated as an active enhancer by the STARR-seq (self-transcribing active regulatory region sequencing) massively parallel reporter assay in HCT116 colorectal carcinoma cells. This sequence was defined as a group 4 enhancer that depends on the BRD2, P300/CBP, MED14 and CDK7 cofactors, but it has limited or no dependence on the BRD4 bromodomain protein. [provided by RefSeq, Sep 2022]
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Genomic context

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Location:
chromosome: 16
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 16 NC_000016.10 (5642154..5643353)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 16 NC_060940.1 (5671588..5672787)

Chromosome 16 - NC_000016.10Genomic Context describing neighboring genes Neighboring gene RNA binding fox-1 homolog 1 Neighboring gene MPRA-validated peak2482 silencer Neighboring gene long intergenic non-protein coding RNA 1570 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr16:5755936-5757135 Neighboring gene MPRA-validated peak2483 silencer Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:5800209-5800710 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:5800711-5801210 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr16:5804472-5805458 Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr16:5845663-5846190 Neighboring gene microRNA 8065 Neighboring gene OCT4-NANOG-H3K4me1 hESC enhancer GRCh37_chr16:5920971-5921940 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:5975719-5976364 Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr16:6052649-6053848 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr16:6072816-6074015 Neighboring gene meiotic recombination hotspot CG Neighboring gene NANOG hESC enhancer GRCh37_chr16:6174118-6174635 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr16:6226269-6227053 Neighboring gene NANOG hESC enhancer GRCh37_chr16:6348193-6348738 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:6372382-6372882 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:6372883-6373383 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr16:6391810-6392696 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr16:6392697-6393582 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:6532635-6533560 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancers GRCh37_chr16:6607366-6608270 and GRCh37_chr16:6608271-6609174 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:6623253-6623754 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:6623755-6624254 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr16:6910998-6911814 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr16:6913069-6913652 Neighboring gene RNA, U7 small nuclear 99 pseudogene Neighboring gene RNA, U6 small nuclear 457, pseudogene

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Differential cofactor dependencies define distinct types of human enhancers. Neumayr C, et al. Nature, 2022 Jun. PMID 35650434, Free PMC Article

GeneRIFs: Gene References Into Functions

Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_086770.1 

    Range
    101..1300
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000016.10 Reference GRCh38.p14 Primary Assembly

    Range
    5642154..5643353
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060940.1 Alternate T2T-CHM13v2.0

    Range
    5671588..5672787
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version

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