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LOC127270681 NANOG-H3K27ac hESC enhancer GRCh37_chr1:161581576-161582270 [ Homo sapiens (human) ]

Gene ID: 127270681, updated on 10-Oct-2023

Summary

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Gene symbol
LOC127270681
Gene description
NANOG-H3K27ac hESC enhancer GRCh37_chr1:161581576-161582270
Gene type
biological region
Feature type(s)
regulatory: enhancer
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
This genomic region was validated as an active enhancer by the ChIP-STARR-seq massively parallel reporter assay in naive human embryonic stem cells. This enhancer associates with the NANOG transcription factor and is marked by the H3K27ac histone modification. [provided by RefSeq, Oct 2022]
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Genomic context

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See LOC127270681 in Genome Data Viewer
Location:
chromosome: 1
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 1 NC_000001.11 (161611786..161612480)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 1 NC_060925.1 (160956127..160956821)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene Fc gamma receptor IIc (gene/pseudogene) Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:161559016-161559516 Neighboring gene ReSE screen-validated silencer GRCh37_chr1:161562499-161562705 Neighboring gene heat shock protein family A (Hsp70) member 7 (pseudogene) Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr1:161582271-161582964 Neighboring gene tRNA-Leu (anticodon CAA) 6-1 Neighboring gene ribosomal protein S23 pseudogene 9 Neighboring gene Sharpr-MPRA regulatory region 4269 Neighboring gene Fc gamma receptor IIIb

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Functional Dissection of the Enhancer Repertoire in Human Embryonic Stem Cells. Barakat TS, et al. Cell Stem Cell, 2018 Aug 2. PMID 30033119, Free PMC Article

GeneRIFs: Gene References Into Functions

Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_092533.1 

    Range
    101..795
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p14 Primary Assembly

    Range
    161611786..161612480
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060925.1 Alternate T2T-CHM13v2.0

    Range
    160956127..160956821
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version

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