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LOC127824620 OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr12:79438588-79439174 [ Homo sapiens (human) ]

Gene ID: 127824620, updated on 10-Oct-2023

Summary

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Gene symbol
LOC127824620
Gene description
OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr12:79438588-79439174
Gene type
biological region
Feature type(s)
regulatory: enhancer
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
This genomic region was validated as an active enhancer by the ChIP-STARR-seq massively parallel reporter assay in naive human embryonic stem cells. This enhancer associates with the OCT4 and NANOG transcription factors and is marked by the H3K27ac and H3K4me1 histone modifications. [provided by RefSeq, Nov 2022]
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Genomic context

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See LOC127824620 in Genome Data Viewer
Location:
chromosome: 12
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 12 NC_000012.12 (79044808..79045394)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 12 NC_060936.1 (79023360..79023946)

Chromosome 12 - NC_000012.12Genomic Context describing neighboring genes Neighboring gene mitochondrial ribosomal protein L11 pseudogene 3 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr12:79045498-79046127 Neighboring gene MED14-independent group 3 enhancer GRCh37_chr12:79152976-79154175 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr12:79187167-79188366 Neighboring gene MPRA-validated peak1851 silencer Neighboring gene RAS like proto-oncogene A pseudogene Neighboring gene NANOG hESC enhancer GRCh37_chr12:79229192-79229693 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr12:79234606-79235418 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr12:79233792-79234605 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 4680 Neighboring gene uncharacterized LOC105369863 Neighboring gene synaptotagmin 1 Neighboring gene uncharacterized LOC124902973 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 6685 Neighboring gene Sharpr-MPRA regulatory region 15006 Neighboring gene RE1 silencing transcription factor pseudogene

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Functional Dissection of the Enhancer Repertoire in Human Embryonic Stem Cells. Barakat TS, et al. Cell Stem Cell, 2018 Aug 2. PMID 30033119, Free PMC Article

GeneRIFs: Gene References Into Functions

Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_126136.1 

    Range
    101..687
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000012.12 Reference GRCh38.p14 Primary Assembly

    Range
    79044808..79045394
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060936.1 Alternate T2T-CHM13v2.0

    Range
    79023360..79023946
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version

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