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LOC127829230 OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr15:35287050-35287721 [ Homo sapiens (human) ]

Gene ID: 127829230, updated on 10-Oct-2023

Summary

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Gene symbol
LOC127829230
Gene description
OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr15:35287050-35287721
Gene type
biological region
Feature type(s)
regulatory: enhancer
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
This genomic region was validated as an active enhancer by the ChIP-STARR-seq massively parallel reporter assay in naive human embryonic stem cells. This enhancer associates with the OCT4 and NANOG transcription factors and is marked by the H3K27ac and H3K4me1 histone modifications. [provided by RefSeq, Nov 2022]
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Genomic context

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See LOC127829230 in Genome Data Viewer
Location:
chromosome: 15
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 15 NC_000015.10 (34994849..34995520)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 15 NC_060939.1 (32800030..32800701)

Chromosome 15 - NC_000015.10Genomic Context describing neighboring genes Neighboring gene aquarius intron-binding spliceosomal factor Neighboring gene ribosomal protein L36a pseudogene 8 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr15:35260004-35260568 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 9183 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 9184 Neighboring gene NANOG-H3K4me1 hESC enhancer GRCh37_chr15:35277351-35278003 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 9185 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 9186 Neighboring gene uncharacterized LOC105370764 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 9187 Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr15:35285419-35286618 Neighboring gene zinc finger protein 770 Neighboring gene uncharacterized LOC105370763 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr15:35312331-35313023 Neighboring gene ReSE screen-validated silencer GRCh37_chr15:35345268-35345500 Neighboring gene uncharacterized LOC105370765 Neighboring gene Nanog homeobox retrogene P8

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Functional Dissection of the Enhancer Repertoire in Human Embryonic Stem Cells. Barakat TS, et al. Cell Stem Cell, 2018 Aug 2. PMID 30033119, Free PMC Article

GeneRIFs: Gene References Into Functions

Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_130712.1 

    Range
    101..772
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000015.10 Reference GRCh38.p14 Primary Assembly

    Range
    34994849..34995520
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    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060939.1 Alternate T2T-CHM13v2.0

    Range
    32800030..32800701
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version

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