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LOC127891584 H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:41724269-41725093 [ Homo sapiens (human) ]

Gene ID: 127891584, updated on 10-Oct-2023

Summary

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Gene symbol
LOC127891584
Gene description
H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:41724269-41725093
Gene type
biological region
Feature type(s)
regulatory: enhancer, silencer
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
This genomic region was validated as an active enhancer by the ChIP-STARR-seq massively parallel reporter assay in naive human embryonic stem cells, where it is marked by the H3K27ac and H3K4me1 histone modifications. An accessible chromatin subregion was used in a lentiviral ReSE (repressive ability of silencer elements) screen that assays for cell survival based on transcriptional repression of an apoptosis-inducing fusion protein. That subregion was identified as a functional silencer in K562 erythroleukemia cells. [provided by RefSeq, Jun 2023]
Annotation information
Note: This locus has been reviewed for its involvement in coronavirus biology, and is regulatory element in the vicinity of coronavirus related gene(s).
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Genomic context

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See LOC127891584 in Genome Data Viewer
Location:
chromosome: 19
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 19 NC_000019.10 (41218364..41219188)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 19 NC_060943.1 (44039248..44040072)

Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC124904790 Neighboring gene H3K27ac hESC enhancer GRCh37_chr19:41698650-41699150 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:41700461-41700973 Neighboring gene RNA, 7SL, cytoplasmic 718, pseudogene Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:41712923-41713700 Neighboring gene cytochrome P450 family 2 subfamily S member 1 Neighboring gene ReSE screen-validated silencer GRCh37_chr19:41718918-41719078 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:41727344-41728281 Neighboring gene H3K27ac hESC enhancer GRCh37_chr19:41730156-41731091 Neighboring gene AXL receptor tyrosine kinase Neighboring gene tRNA-Lys (anticodon TTT) 10-1 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14670 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14671 Neighboring gene H3K27ac hESC enhancer GRCh37_chr19:41768709-41769248 Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr19:41769249-41769788 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:41769789-41770327 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10653 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10654 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10655 Neighboring gene heterogeneous nuclear ribonucleoprotein U like 1 Neighboring gene MPRA-validated peak3484 silencer Neighboring gene RNA, 7SL, cytoplasmic 34, pseudogene

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Systematic identification of silencers in human cells. Pang B, et al. Nat Genet, 2020 Mar. PMID 32094911, Free PMC Article
  2. Functional Dissection of the Enhancer Repertoire in Human Embryonic Stem Cells. Barakat TS, et al. Cell Stem Cell, 2018 Aug 2. PMID 30033119, Free PMC Article

GeneRIFs: Gene References Into Functions

Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

General gene information

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Other Names

  • ReSE screen-validated silencer GRCh37_chr19:41724702-41724841

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_141442.1 

    Range
    101..925
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    GenBank, FASTA, Sequence Viewer (Graphics)

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000019.10 Reference GRCh38.p14 Primary Assembly

    Range
    41218364..41219188
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    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060943.1 Alternate T2T-CHM13v2.0

    Range
    44039248..44040072
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version

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