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LOC127891639 H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:42901001-42901684 [ Homo sapiens (human) ]

Gene ID: 127891639, updated on 10-Oct-2023

Summary

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Gene symbol
LOC127891639
Gene description
H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:42901001-42901684
Gene type
biological region
Feature type(s)
regulatory: enhancer
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
This genomic region includes an enhancer that was validated by the ChIP-STARR-seq massively parallel reporter assay (MPRA) in naive human embryonic stem cells, where it is marked by the H3K27ac and H3K4me1 histone modifications. This locus also includes an accessible chromatin subregion that was validated as an enhancer based on its ability to activate an origin of replication minimal core promoter by the ATAC-STARR-seq (assay for transposase-accessible chromatin with self-transcribing active regulatory region sequencing) MPRA in GM12878 lymphoblastoid cells. [provided by RefSeq, May 2023]
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Genomic context

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See LOC127891639 in Genome Data Viewer
Location:
chromosome: 19
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 19 NC_000019.10 (42396835..42397532)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 19 NC_060943.1 (45216221..45216918)

Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene multiple EGF like domains 8 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:42866515-42867014 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:42873179-42874132 Neighboring gene microRNA 8077 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10712 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10713 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14715 Neighboring gene uncharacterized LOC101930071 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:42901685-42902368 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10714 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:42910752-42911558 Neighboring gene LIPE antisense RNA 1 Neighboring gene cornifelin Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14717 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14718 Neighboring gene lipase E, hormone sensitive type Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10715 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10716 Neighboring gene C-X-C motif chemokine ligand 17

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. ATAC-STARR-seq reveals transcription factor-bound activators and silencers across the chromatin accessible human genome. Hansen TJ, et al. Genome Res, 2022 Jul 20. PMID 35858748, Free PMC Article
  2. Functional Dissection of the Enhancer Repertoire in Human Embryonic Stem Cells. Barakat TS, et al. Cell Stem Cell, 2018 Aug 2. PMID 30033119, Free PMC Article

GeneRIFs: Gene References Into Functions

Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

General gene information

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Other Names

  • ATAC-STARR-seq lymphoblastoid active region 14716

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_141497.2 

    Range
    101..798
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    GenBank, FASTA, Sequence Viewer (Graphics)

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000019.10 Reference GRCh38.p14 Primary Assembly

    Range
    42396835..42397532
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    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060943.1 Alternate T2T-CHM13v2.0

    Range
    45216221..45216918
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version

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