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Kcna5 potassium voltage-gated channel, shaker-related subfamily, member 5 [ Mus musculus (house mouse) ]

Gene ID: 16493, updated on 23-Jun-2021

Summary

Official Symbol
Kcna5provided by MGI
Official Full Name
potassium voltage-gated channel, shaker-related subfamily, member 5provided by MGI
Primary source
MGI:MGI:96662
See related
Ensembl:ENSMUSG00000045534
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Kv1.; Kv1.5
Orthologs
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Genomic context

See Kcna5 in Genome Data Viewer
Location:
6 F3; 6 61.35 cM
Exon count:
1
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 6 NC_000072.7 (126509514..126512518, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 6 NC_000072.6 (126532551..126535555, complement)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 6 NC_000072.5 (126482569..126485573, complement)

Chromosome 6 - NC_000072.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 33276 Neighboring gene 60S ribosomal protein L32 pseudogene Neighboring gene predicted gene, 38899 Neighboring gene predicted gene, 33320 Neighboring gene predicted gene, 33449

Genomic regions, transcripts, and products

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (3)  1 citation
  • Endonuclease-mediated (1) 

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC25248

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables alpha-actinin binding ISO
Inferred from Sequence Orthology
more info
 
enables delayed rectifier potassium channel activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables delayed rectifier potassium channel activity ISO
Inferred from Sequence Orthology
more info
 
enables ion channel activity IEA
Inferred from Electronic Annotation
more info
 
enables outward rectifier potassium channel activity ISO
Inferred from Sequence Orthology
more info
 
enables potassium channel activity IEA
Inferred from Electronic Annotation
more info
 
enables potassium channel inhibitor activity IDA
Inferred from Direct Assay
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein kinase binding ISO
Inferred from Sequence Orthology
more info
 
enables scaffold protein binding ISO
Inferred from Sequence Orthology
more info
 
enables signaling receptor binding ISO
Inferred from Sequence Orthology
more info
 
enables voltage-gated ion channel activity IEA
Inferred from Electronic Annotation
more info
 
enables voltage-gated potassium channel activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables voltage-gated potassium channel activity IDA
Inferred from Direct Assay
more info
PubMed 
enables voltage-gated potassium channel activity involved in SA node cell action potential repolarization ISO
Inferred from Sequence Orthology
more info
 
enables voltage-gated potassium channel activity involved in atrial cardiac muscle cell action potential repolarization ISO
Inferred from Sequence Orthology
more info
 
enables voltage-gated potassium channel activity involved in bundle of His cell action potential repolarization ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
acts_upstream_of_or_within Notch signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
involved_in atrial cardiac muscle cell action potential ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within ion transport IEA
Inferred from Electronic Annotation
more info
 
involved_in ion transport IEA
Inferred from Electronic Annotation
more info
 
involved_in membrane hyperpolarization ISO
Inferred from Sequence Orthology
more info
 
involved_in membrane repolarization during SA node cell action potential ISO
Inferred from Sequence Orthology
more info
 
involved_in membrane repolarization during atrial cardiac muscle cell action potential ISO
Inferred from Sequence Orthology
more info
 
involved_in membrane repolarization during bundle of His cell action potential ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of cytosolic calcium ion concentration ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within negative regulation of potassium ion transport IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of G1/S transition of mitotic cell cycle ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of myoblast proliferation ISO
Inferred from Sequence Orthology
more info
 
involved_in potassium ion export across plasma membrane ISO
Inferred from Sequence Orthology
more info
 
involved_in potassium ion homeostasis ISO
Inferred from Sequence Orthology
more info
 
involved_in potassium ion transmembrane transport IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in potassium ion transmembrane transport ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within potassium ion transport IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within potassium ion transport ISO
Inferred from Sequence Orthology
more info
PubMed 
involved_in protein complex oligomerization ISO
Inferred from Sequence Orthology
more info
 
involved_in protein homooligomerization IEA
Inferred from Electronic Annotation
more info
 
involved_in regulation of atrial cardiac muscle cell membrane repolarization ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of heart rate by cardiac conduction ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within regulation of ion transmembrane transport IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within regulation of membrane potential IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in regulation of membrane potential ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of potassium ion transport ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within regulation of vasoconstriction IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in transmembrane transport IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in Golgi apparatus ISO
Inferred from Sequence Orthology
more info
 
located_in Z disc ISO
Inferred from Sequence Orthology
more info
 
located_in cell surface ISO
Inferred from Sequence Orthology
more info
 
located_in endoplasmic reticulum ISO
Inferred from Sequence Orthology
more info
 
is_active_in integral component of membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in integral component of plasma membrane IC
Inferred by Curator
more info
PubMed 
located_in integral component of plasma membrane ISO
Inferred from Sequence Orthology
more info
 
located_in intercalated disc IDA
Inferred from Direct Assay
more info
PubMed 
located_in intercalated disc ISO
Inferred from Sequence Orthology
more info
 
located_in intracellular canaliculus ISO
Inferred from Sequence Orthology
more info
 
located_in membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in membrane raft ISO
Inferred from Sequence Orthology
more info
 
located_in perinuclear region of cytoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
 
part_of potassium channel complex ISO
Inferred from Sequence Orthology
more info
 
part_of voltage-gated potassium channel complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
part_of voltage-gated potassium channel complex ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
potassium voltage-gated channel subfamily A member 5
Names
KV1-5
voltage-gated potassium channel subunit Kv1.5

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_145983.2NP_666095.1  potassium voltage-gated channel subfamily A member 5

    See identical proteins and their annotated locations for NP_666095.1

    Status: VALIDATED

    Source sequence(s)
    AF108659, BC021787, CX240838
    Consensus CDS
    CCDS20554.1
    UniProtKB/Swiss-Prot
    Q61762
    Related
    ENSMUSP00000055673.4, ENSMUST00000060972.5
    Conserved Domains (4) summary
    smart00225
    Location:113207
    BTB; Broad-Complex, Tramtrack and Bric a brac
    pfam00520
    Location:305515
    Ion_trans; Ion transport protein
    pfam02214
    Location:113204
    BTB_2; BTB/POZ domain
    pfam07885
    Location:429506
    Ion_trans_2; Ion channel

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000072.7 Reference GRCm39 C57BL/6J

    Range
    126509514..126512518 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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