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Giot1 gonadotropin inducible ovarian transcription factor 1 [ Rattus norvegicus (Norway rat) ]

Gene ID: 171090, updated on 11-Apr-2024

Summary

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Official Symbol
Giot1provided by RGD
Official Full Name
gonadotropin inducible ovarian transcription factor 1provided by RGD
Primary source
RGD:620184
See related
Ensembl:ENSRNOG00000051563 AllianceGenome:RGD:620184
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable metal ion binding activity. Predicted to act upstream of or within negative regulation of transcription by RNA polymerase II. Predicted to be located in cytoplasm. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Adrenal (RPKM 143.1), Spleen (RPKM 65.6) and 9 other tissues See more
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Genomic context

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See Giot1 in Genome Data Viewer
Location:
7q11
Exon count:
5
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 7 NC_086025.1 (10868517..10886965, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 7 NC_051342.1 (10215602..10236423, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 7 NC_005106.4 (13104166..13122625, complement)

Chromosome 7 - NC_086025.1Genomic Context describing neighboring genes Neighboring gene phospholipid phosphatase 2 Neighboring gene uncharacterized LOC120093534 Neighboring gene 60 kDa heat shock protein, mitochondrial-like Neighboring gene vomeronasal 2 receptor, 53

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Effects of gonadotropin inducible ovarian transcription factor 1 in the paraventricular nucleus on fluid intake after dehydration of ovariectomized female rats. Terra Dos Santos ALR, et al. Exp Physiol, 2021 Dec. PMID 34713942
  2. Cloning and characterization of gonadotropin-inducible ovarian transcription factors (GIOT1 and -2) that are novel members of the (Cys)(2)-(His)(2)-type zinc finger protein family. Mizutani T, et al. Mol Endocrinol, 2001 Oct. PMID 11579202
  3. A novel Krüppel related factor consisting of only a KRAB domain is expressed in the murine trigeminal ganglion. Nikulina K, et al. Biochem Biophys Res Commun, 2006 Sep 29. PMID 16904636
  4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Effects of gonadotropin inducible ovarian transcription factor 1 in the paraventricular nucleus on fluid intake after dehydration of ovariectomized female rats.
    Title: Effects of gonadotropin inducible ovarian transcription factor 1 in the paraventricular nucleus on fluid intake after dehydration of ovariectomized female rats.
Submit: New GeneRIF Correction

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within negative regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
NOT located_in nucleus ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
gonadotropin inducible ovarian transcription factor 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_133563.1 → NP_598247.1  gonadotropin inducible ovarian transcription factor 1

    See identical proteins and their annotated locations for NP_598247.1

    Status: PROVISIONAL

    Source sequence(s)
    AB047636
    UniProtKB/TrEMBL
    Q91XV2
    Related
    ENSRNOP00000074725.2, ENSRNOT00000080491.2
    Conserved Domains (6) summary
    smart00349
    Location:4 → 46
    KRAB; krueppel associated box
    COG5048
    Location:258 → 654
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:290 → 310
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam01352
    Location:4 → 43
    KRAB; KRAB box
    pfam13465
    Location:553 → 578
    zf-H2C2_2; Zinc-finger double domain
    pfam16278
    Location:508 → 533
    zf-C2HE; C2HE / C2H2 / C2HC zinc-binding finger

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086025.1 Reference GRCr8

    Range
    10868517..10886965 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_063262950.1 → XP_063119020.1  gonadotropin inducible ovarian transcription factor 1 isoform X1

  2. XM_063262949.1 → XP_063119019.1  gonadotropin inducible ovarian transcription factor 1 isoform X1

Nucleotide Protein Strain
Heading Accession and Version

Gene LinkOut

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