U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

htp-3 HORMA domain-containing protein [ Caenorhabditis elegans ]

Gene ID: 172099, updated on 12-Jun-2024

Summary

Go to the top of the page Help
Gene symbol
htp-3
Gene description
HORMA domain-containing protein
Locus tag
CELE_F57C9.5
See related
AllianceGenome:WB:WBGene00002034
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Involved in homologous chromosome pairing at meiosis and meiotic DNA double-strand break formation. Located in chromatin and lateral element. Is expressed in embryonic cell; germ line; and neurons. [provided by Alliance of Genome Resources, Apr 2022]
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
See htp-3 in Genome Data Viewer
Location:
chromosome: I
Exon count:
9
Sequence:
Chromosome: I; NC_003279.8 (4827072..4829791)

Chromosome I - NC_003279.8Genomic Context describing neighboring genes Neighboring gene EthanolaminePhosphoTransferase 1 homolog Neighboring gene G-protein coupled receptors family 1 profile domain-containing protein Neighboring gene Twenty One u-rna (21U-RNA) biogenesis Fouled Up Neighboring gene C2H2-type domain-containing protein Neighboring gene Biogenesis of lysosome-related organelles complex 1 subunit 6;Biogenesis of lysosome-related organelles complex 1 subunit 7 Neighboring gene C-type LECtin

Genomic regions, transcripts, and products

Go to the top of the page Help
Genomic Sequence:
NC_003279.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. PUF-8 facilitates homologous chromosome pairing by promoting proteasome activity during meiotic entry in C. elegans. Kumar GA, et al. Development, 2018 Mar 29. PMID 29540500
  2. The fidelity of synaptonemal complex assembly is regulated by a signaling mechanism that controls early meiotic progression. Silva N, et al. Dev Cell, 2014 Nov 24. PMID 25455309
  3. DNA damage during meiosis induces chromatin remodeling and synaptonemal complex disassembly. Couteau F, et al. Dev Cell, 2011 Mar 15. PMID 21397846
  4. Shugoshin Is Essential for Meiotic Prophase Checkpoints in C. elegans. Bohr T, et al. Curr Biol, 2018 Oct 22. PMID 30293721, Free PMC Article
  5. CRL2(LRR-1) E3-ligase regulates proliferation and progression through meiosis in the Caenorhabditis elegans germline. Burger J, et al. PLoS Genet, 2013 Mar. PMID 23555289, Free PMC Article

See all (23) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. HTP-3 recruits all known AE components to meiotic chromosomes and promotes cohesin loading, the first known involvement of an AE protein in this process
    Title: The axial element protein HTP-3 promotes cohesin loading and meiotic axis assembly in C. elegans to implement the meiotic program of chromosome segregation.
  2. The meiotic axis component HTP-3 links double-strand breaks formation with homolog pairing and synapsis.
    Title: HTP-3 links DSB formation with homolog pairing and crossing over during C. elegans meiosis.
Submit: New GeneRIF Correction

Interactions

Go to the top of the page Help
Products Interactant Other Gene Complex Source Pubs Description

General gene information

Go to the top of the page Help

Markers

Homology

Gene Ontology Provided by WormBase

Process Evidence Code Pubs
involved_in homologous chromosome pairing at meiosis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in meiotic DNA double-strand break formation IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in meiotic DNA double-strand break formation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
part_of chromatin IDA
Inferred from Direct Assay
more info
 PubMed 
located_in condensed chromosome IDA
Inferred from Direct Assay
more info
 PubMed 
located_in lateral element IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

Go to the top of the page Help
Preferred Names
HORMA domain-containing protein
NP_491458.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003279.8 Reference assembly

    Range
    4827072..4829791
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_059057.7 → NP_491458.1  HORMA domain-containing protein [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_491458.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    O01820
    Conserved Domains (2) summary
    cl28054
    Location:358 → 530
    Pox_Ag35; Pox virus Ag35 surface protein
    pfam02301
    Location:37 → 222
    HORMA; HORMA domain
Nucleotide Protein
Heading Accession and Version

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Molecular Biology Databases
Research Materials
Tools