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rme-8 J domain-containing protein [ Caenorhabditis elegans ]

Gene ID: 172594, updated on 12-Jun-2024

Summary

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Gene symbol
rme-8
Gene description
J domain-containing protein
Locus tag
CELE_F18C12.2
See related
AllianceGenome:WB:WBGene00004378
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Enables identical protein binding activity. Involved in several processes, including mechanosensory behavior; positive regulation of nematode male tail tip morphogenesis; and protein localization to postsynaptic membrane. Located in endosome. Is expressed in coelomocyte; hypodermal cell; muscle cell; oocyte; and uterus. Human ortholog(s) of this gene implicated in Parkinson's disease. Orthologous to human DNAJC13 (DnaJ heat shock protein family (Hsp40) member C13). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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See rme-8 in Genome Data Viewer
Location:
chromosome: I
Exon count:
23
Sequence:
Chromosome: I; NC_003279.8 (8083576..8095610)

Chromosome I - NC_003279.8Genomic Context describing neighboring genes Neighboring gene Small integral membrane protein 29 Neighboring gene Cytoplasmic dynein 2 heavy chain 1 Neighboring gene ncRNA Neighboring gene Serum response factor-binding protein 1 Neighboring gene Suppressor of presenilin protein 4

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003279.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. RME-8, a conserved J-domain protein, is required for endocytosis in Caenorhabditis elegans. Zhang Y, et al. Mol Biol Cell, 2001 Jul. PMID 11451999, Free PMC Article
  2. Receptor-mediated endocytosis 8 (RME-8)/DNAJC13 is a novel positive modulator of autophagy and stabilizes cellular protein homeostasis. Besemer AS, et al. Cell Mol Life Sci, 2021 Jan. PMID 32322926, Free PMC Article
  3. The DnaJ-domain protein RME-8 functions in endosomal trafficking. Girard M, et al. J Biol Chem, 2005 Dec 2. PMID 16179350
  4. Regulation of endocytosis by CUP-5, the Caenorhabditis elegans mucolipin-1 homolog. Fares H, et al. Nat Genet, 2001 May. PMID 11326278
  5. SNX-1 and RME-8 oppose the assembly of HGRS-1/ESCRT-0 degradative microdomains on endosomes. Norris A, et al. Proc Natl Acad Sci U S A, 2017 Jan 17. PMID 28053230, Free PMC Article

See all (33) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Receptor-mediated endocytosis 8 (RME-8)/DNAJC13 is a novel positive modulator of autophagy and stabilizes cellular protein homeostasis.
    Title: Receptor-mediated endocytosis 8 (RME-8)/DNAJC13 is a novel positive modulator of autophagy and stabilizes cellular protein homeostasis.
  2. Loss of SNX-1, RME-8, or the clathrin chaperone Hsc70/HSP-1 leads to over-accumulation of endosomal clathrin, reduced clathrin dynamics, and missorting of MIG-14 to the lysosome.
    Title: Regulation of endosomal clathrin and retromer-mediated endosome to Golgi retrograde transport by the J-domain protein RME-8.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables identical protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein-folding chaperone binding ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
Process Evidence Code Pubs
involved_in embryo development ending in birth or egg hatching IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in endosome organization IEA
Inferred from Electronic Annotation
more info
  
involved_in mechanosensory behavior IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in nematode larval development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of nematode male tail tip morphogenesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in protein localization to postsynaptic membrane IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in receptor-mediated endocytosis IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in receptor-mediated endocytosis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of early endosome to late endosome transport IEA
Inferred from Electronic Annotation
more info
  
involved_in retrograde transport, endosome to Golgi IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in cytosol IEA
Inferred from Electronic Annotation
more info
  
located_in early endosome IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in endosome membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in endosome membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in late endosome IDA
Inferred from Direct Assay
more info
 PubMed 
located_in recycling endosome IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
J domain-containing protein
NP_001021395.1
  • Confirmed by transcript evidence
NP_492222.2
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003279.8 Reference assembly

    Range
    8083576..8095610
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001026224.6 → NP_001021395.1  J domain-containing protein [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001021395.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    O62178
    Conserved Domains (2) summary
    pfam00226
    Location:1324 → 1378
    DnaJ; DnaJ domain
    pfam14237
    Location:983 → 1033
    DUF4339; Domain of unknown function (DUF4339)

  2. NM_059821.5 → NP_492222.2  J domain-containing protein [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_492222.2

    Status: REVIEWED

    UniProtKB/TrEMBL
    G5ED36
    Conserved Domains (2) summary
    pfam00226
    Location:1324 → 1378
    DnaJ; DnaJ domain
    pfam14237
    Location:983 → 1033
    DUF4339; Domain of unknown function (DUF4339)
Nucleotide Protein
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