U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

ztf-11 Zinc finger protein ztf-11 [ Caenorhabditis elegans ]

Gene ID: 172845, updated on 12-Jun-2024

Summary

Go to the top of the page Help
Gene symbol
ztf-11
Gene description
Zinc finger protein ztf-11
Locus tag
CELE_F52F12.6
See related
AllianceGenome:WB:WBGene00009939
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable zinc ion binding activity. Involved in nematode larval development; neuron differentiation; and positive regulation of cell differentiation. Located in nucleus. Is expressed in g1 and head neurons. Human ortholog(s) of this gene implicated in autosomal dominant non-syndromic intellectual disability 39. Orthologous to human ST18 (ST18 C2H2C-type zinc finger transcription factor); MYT1 (myelin transcription factor 1); and MYT1L (myelin transcription factor 1 like). [provided by Alliance of Genome Resources, Apr 2022]
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
See ztf-11 in Genome Data Viewer
Location:
chromosome: I
Exon count:
8
Sequence:
Chromosome: I; NC_003279.8 (9904303..9910545, complement)

Chromosome I - NC_003279.8Genomic Context describing neighboring genes Neighboring gene Nematode cuticle collagen N-terminal domain-containing protein Neighboring gene Mitogen-activated protein kinase kinase kinase mom-4 Neighboring gene C2H2-type domain-containing protein Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA

Genomic regions, transcripts, and products

Go to the top of the page Help
Genomic Sequence:
NC_003279.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. Silencing the alternative. Sivaramakrishnan P, et al. Elife, 2019 Aug 6. PMID 31386622, Free PMC Article
  2. A Myt1 family transcription factor defines neuronal fate by repressing non-neuronal genes. Lee J, et al. Elife, 2019 Aug 6. PMID 31386623, Free PMC Article
  3. Cell architecture: surrounding muscle cells shape gland cell morphology in the Caenorhabditis elegans pharynx. Raharjo WH, et al. Genetics, 2011 Nov. PMID 21868609, Free PMC Article
  4. Novel LOTUS-domain proteins are organizational hubs that recruit C. elegans Vasa to germ granules. Cipriani PG, et al. Elife, 2021 Jul 5. PMID 34223818, Free PMC Article
  5. OrthoList: a compendium of C. elegans genes with human orthologs. Shaye DD, et al. PLoS One, 2011. PMID 21647448, Free PMC Article

See all (7) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

Go to the top of the page Help
Products Interactant Other Gene Complex Source Pubs Description

General gene information

Go to the top of the page Help

Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables zinc ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in negative regulation of transcription by RNA polymerase II IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in nematode larval development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in nervous system development IEA
Inferred from Electronic Annotation
more info
  
involved_in neuron development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in neuron fate determination IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in neuron fate specification IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of neuron differentiation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of transdifferentiation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of DNA-templated transcription IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

Go to the top of the page Help
Preferred Names
Zinc finger protein ztf-11
NP_001251245.1
  • Confirmed by transcript evidence
NP_001251246.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003279.8 Reference assembly

    Range
    9904303..9910545 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001264316.3 → NP_001251245.1  Zinc finger protein ztf-11 [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001251245.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    H2L2J7, O02274
    UniProtKB/TrEMBL
    Q94138
    Conserved Domains (1) summary
    pfam01530
    Location:265 → 291
    zf-C2HC; Zinc finger, C2HC type

  2. NM_001264317.3 → NP_001251246.1  Zinc finger protein ztf-11 [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001251246.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q94138
    Conserved Domains (1) summary
    pfam01530
    Location:168 → 193
    zf-C2HC; Zinc finger, C2HC type
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
O02274.3

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Molecular Biology Databases
Research Materials
Tools