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ran-1 GTP-binding nuclear protein ran-1 [ Caenorhabditis elegans ]

Gene ID: 176503, updated on 12-Jun-2024

Summary

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Gene symbol
ran-1
Gene description
GTP-binding nuclear protein ran-1
Locus tag
CELE_K01G5.4
See related
AllianceGenome:WB:WBGene00004302
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable GTPase activity. Involved in embryo development and oogenesis. Predicted to be located in kinetochore. Predicted to be active in cytoplasm and nucleus. Human ortholog(s) of this gene implicated in type 1 diabetes mellitus. Orthologous to human RAN (RAN, member RAS oncogene family). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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See ran-1 in Genome Data Viewer
Location:
chromosome: III
Exon count:
5
Sequence:
Chromosome: III; NC_003281.10 (10746581..10747728, complement)

Chromosome III - NC_003281.10Genomic Context describing neighboring genes Neighboring gene Protein FAM32A Neighboring gene Tubulin beta chain Neighboring gene Exostosin-2 homolog Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene Putative H/ACA ribonucleoprotein complex subunit 4

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003281.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Microtubule assembly and pole coalescence: early steps in Caenorhabditiselegans oocyte meiosis I spindle assembly. Chuang CH, et al. Biol Open, 2020 Jun 25. PMID 32493729, Free PMC Article
  2. Proteomics analysis in Caenorhabditis elegans to elucidate the response induced by tyrosol, an olive phenol that stimulates longevity and stress resistance. Cañuelo A, et al. Proteomics, 2013 Oct. PMID 23929540
  3. Caenorhabditis elegans BAF-1 and its kinase VRK-1 participate directly in post-mitotic nuclear envelope assembly. Gorjánácz M, et al. EMBO J, 2007 Jan 10. PMID 17170708, Free PMC Article
  4. The GTPase Ran regulates chromosome positioning and nuclear envelope assembly in vivo. Bamba C, et al. Curr Biol, 2002 Mar 19. PMID 11909538
  5. Chromatids segregate without centrosomes during Caenorhabditis elegans mitosis in a Ran- and CLASP-dependent manner. Nahaboo W, et al. Mol Biol Cell, 2015 Jun 1. PMID 25833711, Free PMC Article

See all (33) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables GTP binding IEA
Inferred from Electronic Annotation
more info
  
enables GTPase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables GTPase activity IEA
Inferred from Electronic Annotation
more info
  
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in cell cycle IEA
Inferred from Electronic Annotation
more info
  
involved_in cell division IEA
Inferred from Electronic Annotation
more info
  
involved_in embryo development ending in birth or egg hatching IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in nucleocytoplasmic transport IEA
Inferred from Electronic Annotation
more info
  
involved_in oogenesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in protein import into nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein transport IEA
Inferred from Electronic Annotation
more info
  
involved_in ribosomal subunit export from nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in chromosome IEA
Inferred from Electronic Annotation
more info
  
located_in chromosome, centromeric region IEA
Inferred from Electronic Annotation
more info
  
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in kinetochore IEA
Inferred from Electronic Annotation
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
GTP-binding nuclear protein ran-1
NP_499369.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003281.10 Reference assembly

    Range
    10746581..10747728 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_066968.8 → NP_499369.1  GTP-binding nuclear protein ran-1 [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_499369.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    O17915
    Conserved Domains (1) summary
    PTZ00132
    Location:1 → 206
    PTZ00132; GTP-binding nuclear protein Ran; Provisional
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
O17915.1

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