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rsks-1 Ribosomal protein S6 kinase beta [ Caenorhabditis elegans ]

Gene ID: 176554, updated on 25-Apr-2024

Summary

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Gene symbol
rsks-1
Gene description
Ribosomal protein S6 kinase beta
Primary source
WormBase:WBGene00012929
Locus tag
CELE_Y47D3A.16
See related
AllianceGenome:WB:WBGene00012929
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable ribosomal protein S6 kinase activity. Involved in several processes, including determination of adult lifespan; nematode larval development; and positive regulation of autophagosome assembly. Predicted to be located in axon and perikaryon. Predicted to be active in cytoplasm and nucleus. Is expressed in several structures, including Eal; Eala; Ealaa; Ealp; and Ear. Orthologous to human RPS6KB1 (ribosomal protein S6 kinase B1) and RPS6KB2 (ribosomal protein S6 kinase B2). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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Location:
chromosome: III
Exon count:
6
Sequence:
Chromosome: III; NC_003281.10 (11245120..11252281)

Chromosome III - NC_003281.10Genomic Context describing neighboring genes Neighboring gene CMP/dCMP-type deaminase domain-containing protein Neighboring gene ncRNA Neighboring gene Association with the SNF1 complex (ASC) domain-containing protein Neighboring gene Uncharacterized protein Neighboring gene Oxysterol-binding protein

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003281.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. A mutation that alters the 255th glutamate to lysine in RSKS-1/S6 kinase reliably extends the lifespan of C. elegans. Lee J, et al. MicroPubl Biol, 2020 Oct 27. PMID 33274335, Free PMC Article
  2. Epigenetic control of lipid metabolism: implications for lifespan and healthspan. Schiattarella GG, et al. Cardiovasc Res, 2018 May 1. PMID 29897494, Free PMC Article
  3. The mTOR-S6 kinase pathway promotes stress granule assembly. Sfakianos AP, et al. Cell Death Differ, 2018 Nov. PMID 29523872, Free PMC Article
  4. Inhibition of mTOR decreases insoluble proteins burden by reducing translation in C. elegans. Yee Z, et al. Biogerontology, 2021 Feb. PMID 33159806
  5. The mTOR Target S6 Kinase Arrests Development in Caenorhabditis elegans When the Heat-Shock Transcription Factor Is Impaired. Chisnell P, et al. Genetics, 2018 Nov. PMID 30228197, Free PMC Article

See all (46) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. mTOR Target S6 Kinase Arrests Development in Caenorhabditis elegans When the Heat-Shock Transcription Factor Is Impaired
    Title: The mTOR Target S6 Kinase Arrests Development in Caenorhabditis elegans When the Heat-Shock Transcription Factor Is Impaired.
  2. mir-259 functioned in pharynx-intestinal valve and RSKS-1 functioned in pharynx to regulate MWCNTs toxicity. Furthermore, RSKS-1 regulated MWCNTs toxicity by suppressing the function of AAK-2-DAF-16 signaling cascade. Our results will strengthen our understanding the microRNAs mediated protection mechanisms for animals against the toxicity from certain nanomaterials.
    Title: Function of RSKS-1-AAK-2-DAF-16 signaling cascade in enhancing toxicity of multi-walled carbon nanotubes can be suppressed by mir-259 activation in Caenorhabditis elegans.
  3. Inhibiting rsks-1 in the germline leads to cell-nonautonomous activation of DAF-16. The daf-2 rsks-1 double mutant shows synergistic lifespan extension.
    Title: Germline signaling mediates the synergistically prolonged longevity produced by double mutations in daf-2 and rsks-1 in C. elegans.
  4. RSKS-1 is not required for axonal development but inhibits axon regrowth in multiple neuron types.
    Title: S6 kinase inhibits intrinsic axon regeneration capacity via AMP kinase in Caenorhabditis elegans.
  5. Results establish the C. elegans germ line as an in vivo model to understand TOR-S6K signaling in proliferation and differentiation and suggest that this pathway is a key nutrient-responsive regulator of germline progenitors.
    Title: S6K links cell fate, cell cycle and nutrient response in C. elegans germline stem/progenitor cells.
Submit: New GeneRIF Correction

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
  
enables protein kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein serine kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein serine/threonine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein serine/threonine kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables transferase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in determination of adult lifespan IGI
Inferred from Genetic Interaction
more info
 PubMed 
NOT involved_in determination of adult lifespan IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in determination of adult lifespan IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in nematode larval development IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in peptidyl-serine phosphorylation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in phosphorylation IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of autophagosome assembly IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of gene expression IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in protein phosphorylation IEA
Inferred from Electronic Annotation
more info
  
involved_in signal transduction IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in axon IEA
Inferred from Electronic Annotation
more info
  
located_in cell projection IEA
Inferred from Electronic Annotation
more info
  
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in nucleoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in perikaryon IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
Ribosomal protein S6 kinase beta
NP_499447.2
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003281.10 Reference assembly

    Range
    11245120..11252281
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_067046.4 → NP_499447.2  Ribosomal protein S6 kinase beta [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_499447.2

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q9NAH6
    Conserved Domains (2) summary
    smart00220
    Location:83 → 344
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd05584
    Location:86 → 408
    STKc_p70S6K; Catalytic domain of the Serine/Threonine Kinase, 70 kDa ribosomal protein S6 kinase
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9NAH6.2

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