C02B10.6 Protein-tyrosine phosphatase [Caenorhabditis elegans] - Gene

Summary

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Gene symbol: C02B10.6
Gene description: Protein-tyrosine phosphatase
Locus tag: CELE_C02B10.6
See related: AllianceGenome:WB:WBGene00015331
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Predicted to enable protein tyrosine phosphatase activity. Predicted to be involved in peptidyl-tyrosine dephosphorylation. Orthologous to human PTPN20 (protein tyrosine phosphatase non-receptor type 20). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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See C02B10.6 in Genome Data Viewer

Location:: chromosome: IV

Exon count:: 3

Sequence:: Chromosome: IV; NC_003282.8 (5070893..5072263)

Chromosome IV - NC_003282.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003282.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

R13H9.1 (e-PCR)
- UniSTS:305696

F36H12.10 (e-PCR)
- UniSTS:310156

C02B10.6 (e-PCR)
- UniSTS:305560

Y72A2B.a (e-PCR)
- UniSTS:323321

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables protein tyrosine phosphatase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in protein dephosphorylation	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: Protein-tyrosine phosphatase

NP_500718.1

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003282.8 Reference assembly

Range

5070893..5072263

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_068317.3 → NP_500718.1 Protein-tyrosine phosphatase [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_500718.1

Status: REVIEWED

UniProtKB/TrEMBL

O44448

Conserved Domains (2) summary

smart00194
Location:101 → 363

PTPc; Protein tyrosine phosphatase, catalytic domain

cd00047
Location:133 → 363

PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...