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blos-2 Biogenesis of lysosome-related organelles complex 1 subunit 2 [ Caenorhabditis elegans ]

Gene ID: 177395, updated on 12-Jun-2024

Summary

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Gene symbol
blos-2
Gene description
Biogenesis of lysosome-related organelles complex 1 subunit 2
Locus tag
CELE_Y73B6BL.30
See related
AllianceGenome:WB:WBGene00022251
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable gamma-tubulin binding activity. Involved in endosomal transport. Predicted to be part of BLOC-1 complex; BORC complex; and gamma-tubulin complex. Is expressed in head; pharyngeal-intestinal valve; and pharynx. Orthologous to human BLOC1S2 (biogenesis of lysosomal organelles complex 1 subunit 2). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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See blos-2 in Genome Data Viewer
Location:
chromosome: IV
Exon count:
4
Sequence:
Chromosome: IV; NC_003282.8 (6334215..6335168)

Chromosome IV - NC_003282.8Genomic Context describing neighboring genes Neighboring gene U6 snRNA-associated Sm-like protein LSm8 Neighboring gene Protein seu-1 Neighboring gene Macrophage migration inhibitory factor Neighboring gene PNPLA domain-containing protein

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003282.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. C. elegans BLOC-1 functions in trafficking to lysosome-related gut granules. Hermann GJ, et al. PLoS One, 2012. PMID 22916203, Free PMC Article
  2. Novel LOTUS-domain proteins are organizational hubs that recruit C. elegans Vasa to germ granules. Cipriani PG, et al. Elife, 2021 Jul 5. PMID 34223818, Free PMC Article
  3. OrthoList: a compendium of C. elegans genes with human orthologs. Shaye DD, et al. PLoS One, 2011. PMID 21647448, Free PMC Article
  4. OrthoList 2: A New Comparative Genomic Analysis of Human and Caenorhabditis elegans Genes. Kim W, et al. Genetics, 2018 Oct. PMID 30120140, Free PMC Article
  5. Genome sequence of the nematode C. elegans: a platform for investigating biology. C. elegans Sequencing Consortium. Science, 1998 Dec 11. PMID 9851916

See all (6) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables gamma-tubulin binding IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in endosomal transport IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in endosomal transport IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in lysosome localization IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
part_of BLOC-1 complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of BLOC-1 complex TAS
Traceable Author Statement
more info
 PubMed 
part_of BORC complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of gamma-tubulin complex IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
Biogenesis of lysosome-related organelles complex 1 subunit 2
NP_001368404.1
  • Confirmed by transcript evidence
NP_500967.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003282.8 Reference assembly

    Range
    6334215..6335168
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_068566.6 → NP_500967.1  Biogenesis of lysosome-related organelles complex 1 subunit 2 [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_500967.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q95XD3
    Conserved Domains (1) summary
    pfam10046
    Location:31 → 124
    BLOC1_2; Biogenesis of lysosome-related organelles complex-1 subunit 2

  2. NM_001380271.1 → NP_001368404.1  Biogenesis of lysosome-related organelles complex 1 subunit 2 [Caenorhabditis elegans]

    Status: REVIEWED

    UniProtKB/TrEMBL
    V6CLS1
    Conserved Domains (1) summary
    pfam10046
    Location:1 → 69
    BLOC1_2; Biogenesis of lysosome-related organelles complex-1 subunit 2
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q95XD3.1

Gene LinkOut

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