ddi-1 Protein DDI1 homolog 1 [Caenorhabditis elegans] - Gene

Summary

Go to the top of the page Help

Gene symbol: ddi-1
Gene description: Protein DDI1 homolog 1
Locus tag: CELE_C01G5.6
See related: AllianceGenome:WB:WBGene00015308
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Predicted to enable aspartic-type endopeptidase activity. Involved in negative regulation of synapse assembly. Located in cytoplasm and nucleus. Is expressed widely. Orthologous to several human genes including DDI1 (DNA damage inducible 1 homolog 1) and DDI2 (DNA damage inducible 1 homolog 2). [provided by Alliance of Genome Resources, Apr 2022]
NEW: Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help

See ddi-1 in Genome Data Viewer

Location:: chromosome: IV

Exon count:: 7

Sequence:: Chromosome: IV; NC_003282.8 (6522867..6524571)

Chromosome IV - NC_003282.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to reference sequence details

Genomic Sequence:: NC_003282.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

Go to the top of the page Help

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

DDI-1 expression is induced by proteasome dysfunction, and the authors show that DDI-1 is required to cleave and activate an endoplasmic reticulum-associated isoform of SKN-1.
Title: Proteasome dysfunction triggers activation of SKN-1A/Nrf1 by the aspartic protease DDI-1.

Submit: New GeneRIF Correction

Interactions

Go to the top of the page Help

Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

Go to the top of the page Help

Markers

C01G5.6 (e-PCR)
- UniSTS:308875

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables aspartic-type endopeptidase activity	IEA Inferred from Electronic Annotation more info
enables hydrolase activity	IEA Inferred from Electronic Annotation more info
enables peptidase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in negative regulation of synapse assembly	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in proteolysis	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	IEA Inferred from Electronic Annotation more info

General protein information

Go to the top of the page Help

Preferred Names: Protein DDI1 homolog 1

NP_500992.1

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003282.8 Reference assembly

Range

6522867..6524571

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_068591.5 → NP_500992.1 Protein DDI1 homolog 1 [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_500992.1

Status: REVIEWED

UniProtKB/Swiss-Prot

Q17569

Conserved Domains (1) summary

pfam09668
Location:221 → 345

Asp_protease; Aspartyl protease