rpl-12 Large ribosomal subunit protein uL11 [Caenorhabditis elegans] - Gene

Summary

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Gene symbol: rpl-12
Gene description: Large ribosomal subunit protein uL11
Primary source: WormBase:WBGene00004424
Locus tag: CELE_JC8.3
See related: AllianceGenome:WB:WBGene00004424
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Predicted to enable large ribosomal subunit rRNA binding activity. Predicted to be a structural constituent of ribosome. Involved in regulation of alternative mRNA splicing, via spliceosome. Predicted to be located in ribosome. Predicted to be part of cytosolic large ribosomal subunit. Is expressed in several structures, including enteric muscle; excretory system; hypodermis; nervous system; and pharynx. Human ortholog(s) of this gene implicated in systemic lupus erythematosus. Orthologous to human RPL12 (ribosomal protein L12). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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See rpl-12 in Genome Data Viewer

Location:: chromosome: IV

Exon count:: 4

Sequence:: Chromosome: IV; NC_003282.8 (13239587..13240651, complement)

Chromosome IV - NC_003282.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003282.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

JC8.6 (e-PCR)
- UniSTS:317501

STS4-10 (e-PCR)
- UniSTS:242086

JC8.3 (e-PCR)
- UniSTS:316899

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables RNA binding	IEA Inferred from Electronic Annotation more info
enables large ribosomal subunit rRNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables structural constituent of ribosome	IBA Inferred from Biological aspect of Ancestor more info
enables structural constituent of ribosome	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in regulation of alternative mRNA splicing, via spliceosome	IDA Inferred from Direct Assay more info	PubMed
involved_in translation	IBA Inferred from Biological aspect of Ancestor more info
involved_in translation	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
part_of cytosolic large ribosomal subunit	IBA Inferred from Biological aspect of Ancestor more info
part_of ribonucleoprotein complex	IEA Inferred from Electronic Annotation more info
located_in ribosome	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: Large ribosomal subunit protein uL11

NP_001040960.1

Partially confirmed by transcript evidence

NP_502542.1

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003282.8 Reference assembly

Range

13239587..13240651 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_070141.10 → NP_502542.1 Large ribosomal subunit protein uL11 [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_502542.1

Status: REVIEWED

UniProtKB/Swiss-Prot

P61866, Q2EEM7

Conserved Domains (1) summary

PLN03072
Location:1 → 163

PLN03072; 60S ribosomal protein L12; Provisional
NM_001047495.6 → NP_001040960.1 Large ribosomal subunit protein uL11 [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_001040960.1

Status: REVIEWED

UniProtKB/Swiss-Prot

P61866

Conserved Domains (1) summary

cl21729
Location:1 → 28

Ribosomal_L11; Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal ...