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csn-6 COP9 signalosome complex subunit 6 [ Caenorhabditis elegans ]

Gene ID: 178289, updated on 12-Jun-2024

Summary

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Gene symbol
csn-6
Gene description
COP9 signalosome complex subunit 6
Locus tag
CELE_Y67H2A.6
See related
AllianceGenome:WB:WBGene00000818
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable isopeptidase activity and metallopeptidase activity. Predicted to be involved in oogenesis and proteolysis. Predicted to be located in cytoplasm and nucleus. Predicted to be part of COP9 signalosome. Orthologous to human COPS6 (COP9 signalosome subunit 6). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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See csn-6 in Genome Data Viewer
Location:
chromosome: IV
Exon count:
5
Sequence:
Chromosome: IV; NC_003282.8 (13300824..13303711)

Chromosome IV - NC_003282.8Genomic Context describing neighboring genes Neighboring gene Calcium uptake protein 1 homolog, mitochondrial Neighboring gene KASH (Klarsicht/ANC-1/Syne Homology) Domain Protein Neighboring gene Peptidase M3A/M3B catalytic domain-containing protein Neighboring gene Omega-3 fatty acid desaturase fat-1

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003282.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. CSN-5, a component of the COP9 signalosome complex, regulates the levels of UNC-96 and UNC-98, two components of M-lines in Caenorhabditis elegans muscle. Miller RK, et al. Mol Biol Cell, 2009 Aug. PMID 19535455, Free PMC Article
  2. Neddylation and deneddylation of CUL-3 is required to target MEI-1/Katanin for degradation at the meiosis-to-mitosis transition in C. elegans. Pintard L, et al. Curr Biol, 2003 May 27. PMID 12781129
  3. CIF-1, a shared subunit of the COP9/signalosome and eukaryotic initiation factor 3 complexes, regulates MEL-26 levels in the Caenorhabditis elegans embryo. Luke-Glaser S, et al. Mol Cell Biol, 2007 Jun. PMID 17403899, Free PMC Article
  4. Germline Maintenance Through the Multifaceted Activities of GLH/Vasa in Caenorhabditis elegans P Granules. Marnik EA, et al. Genetics, 2019 Nov. PMID 31506335, Free PMC Article
  5. A protein domain-based interactome network for C. elegans early embryogenesis. Boxem M, et al. Cell, 2008 Aug 8. PMID 18692475, Free PMC Article

See all (12) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables metallopeptidase activity IEA
Inferred from Electronic Annotation
more info
  
enables peptidase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in cell differentiation IEA
Inferred from Electronic Annotation
more info
  
involved_in oogenesis IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
part_of COP9 signalosome IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of COP9 signalosome IEA
Inferred from Electronic Annotation
more info
  
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
COP9 signalosome complex subunit 6
NP_001255725.1
  • Confirmed by transcript evidence
NP_001255726.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003282.8 Reference assembly

    Range
    13300824..13303711
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001268797.3 → NP_001255726.1  COP9 signalosome complex subunit 6 [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001255726.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q95PZ0
    Conserved Domains (1) summary
    cl13996
    Location:13 → 269
    MPN; Mpr1p, Pad1p N-terminal (MPN) domains

  2. NM_001268796.5 → NP_001255725.1  COP9 signalosome complex subunit 6 [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001255725.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    C5VUK2
    Conserved Domains (1) summary
    cl13996
    Location:13 → 269
    MPN; Mpr1p, Pad1p N-terminal (MPN) domains
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q95PZ0.1

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