zipt-7.1 Zinc transporter zipt-7.1 [Caenorhabditis elegans] - Gene

Summary

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Gene symbol: zipt-7.1
Gene description: Zinc transporter zipt-7.1
Locus tag: CELE_T28F3.3
See related: AllianceGenome:WB:WBGene00044067
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Enables zinc ion transmembrane transporter activity. Involved in several processes, including cellular zinc ion homeostasis; positive regulation of brood size; and positive regulation of fertilization. Located in membrane. Is expressed in several structures, including germ line; intestine; nervous system; spermatocyte; and vulva. Orthologous to human SLC39A7 (solute carrier family 39 member 7). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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See zipt-7.1 in Genome Data Viewer

Location:: chromosome: IV

Exon count:: 6

Sequence:: Chromosome: IV; NC_003282.8 (17285733..17287454, complement)

Chromosome IV - NC_003282.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003282.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

We propose a new model for sperm activation. In spermatids, inactive ZIPT-7.1 is localized to the membranous organelles, which contain higher levels of zinc than the cytoplasm. When sperm activation is triggered, ZIPT-7.1 activity increases, releasing zinc from internal stores.
Title: The zinc transporter ZIPT-7.1 regulates sperm activation in nematodes.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

F26D10.5 (e-PCR)
- UniSTS:321407

T28F3.3 (e-PCR)
- UniSTS:312795

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables metal ion transmembrane transporter activity	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables zinc ion transmembrane transporter activity	IBA Inferred from Biological aspect of Ancestor more info
enables zinc ion transmembrane transporter activity	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in cell differentiation	IEA Inferred from Electronic Annotation more info
involved_in intracellular zinc ion homeostasis	IBA Inferred from Biological aspect of Ancestor more info
involved_in intracellular zinc ion homeostasis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in metal ion transport	IEA Inferred from Electronic Annotation more info
involved_in monoatomic ion transport	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of brood size	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of fertilization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of egg-laying behavior	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in spermatid differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in spermatogenesis	IEA Inferred from Electronic Annotation more info
involved_in transmembrane transport	IEA Inferred from Electronic Annotation more info
involved_in zinc ion transmembrane transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in zinc ion transport	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in membrane	IDA Inferred from Direct Assay more info	PubMed
located_in membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: Zinc transporter zipt-7.1

NP_503070.2

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003282.8 Reference assembly

Range

17285733..17287454 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_070669.6 → NP_503070.2 Zinc transporter zipt-7.1 [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_503070.2

Status: REVIEWED

UniProtKB/Swiss-Prot

Q9XUC4

Conserved Domains (1) summary

pfam02535
Location:81 → 389

Zip; ZIP Zinc transporter