U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

famk-1 Extracellular serine/threonine protein kinase CeFam20 [ Caenorhabditis elegans ]

Gene ID: 181616, updated on 25-Apr-2024

Summary

Go to the top of the page Help
Gene symbol
famk-1
Gene description
Extracellular serine/threonine protein kinase CeFam20
Primary source
WormBase:WBGene00010356
Locus tag
CELE_H03A11.1
See related
AllianceGenome:WB:WBGene00010356
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Enables manganese ion binding activity and protein serine/threonine kinase activity. Involved in protein phosphorylation. Predicted to be located in extracellular region. Predicted to colocalize with Golgi apparatus. Is expressed in several structures, including body wall musculature; gonad; oocyte; rectum; and vulva. Human ortholog(s) of this gene implicated in amelogenesis imperfecta and amelogenesis imperfecta type 1G. Orthologous to several human genes including FAM20C (FAM20C golgi associated secretory pathway kinase). [provided by Alliance of Genome Resources, Apr 2022]
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
Location:
chromosome: X
Exon count:
9
Sequence:
Chromosome: X; NC_003284.9 (15209289..15213259, complement)

Chromosome X - NC_003284.9Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene tRNA-Gly Neighboring gene ncRNA Neighboring gene tRNA-Gly Neighboring gene Uncharacterized protein Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA

Genomic regions, transcripts, and products

Go to the top of the page Help
Genomic Sequence:
NC_003284.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. Crystal structure of the Golgi casein kinase. Xiao J, et al. Proc Natl Acad Sci U S A, 2013 Jun 25. PMID 23754375, Free PMC Article
  2. Ancestral roles of the Fam20C family of secreted protein kinases revealed in C. elegans. Gerson-Gurwitz A, et al. J Cell Biol, 2019 Nov 4. PMID 31541016, Free PMC Article
  3. OrthoList: a compendium of C. elegans genes with human orthologs. Shaye DD, et al. PLoS One, 2011. PMID 21647448, Free PMC Article
  4. OrthoList 2: A New Comparative Genomic Analysis of Human and Caenorhabditis elegans Genes. Kim W, et al. Genetics, 2018 Oct. PMID 30120140, Free PMC Article
  5. Genome sequence of the nematode C. elegans: a platform for investigating biology. C. elegans Sequencing Consortium. Science, 1998 Dec 11. PMID 9851916

See all (6) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

Go to the top of the page

Interactions

Go to the top of the page Help
Products Interactant Other Gene Complex Source Pubs Description

General gene information

Go to the top of the page Help

Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables manganese ion binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
  
enables protein serine kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein serine/threonine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein serine/threonine kinase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables protein serine/threonine kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables transferase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in phosphorylation IEA
Inferred from Electronic Annotation
more info
  
involved_in protein phosphorylation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein phosphorylation IDA
Inferred from Direct Assay
more info
 PubMed 
Component Evidence Code Pubs
colocalizes_with Golgi apparatus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in Golgi apparatus IEA
Inferred from Electronic Annotation
more info
  
located_in Golgi membrane IEA
Inferred from Electronic Annotation
more info
  
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

Go to the top of the page Help
Preferred Names
Extracellular serine/threonine protein kinase CeFam20
NP_510527.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003284.9 Reference assembly

    Range
    15209289..15213259 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_078126.5 → NP_510527.1  Extracellular serine/threonine protein kinase CeFam20 [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_510527.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q9XTW2
    Conserved Domains (2) summary
    pfam06702
    Location:260 → 474
    Fam20C; Golgi casein kinase, C-terminal, Fam20
    pfam15051
    Location:218 → 239
    FAM198; FAM198 protein
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9XTW2.1

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Molecular Biology Databases
Research Materials
Tools
Miscellaneous