mlc-1 Myosin regulatory light chain 1 [Caenorhabditis elegans] - Gene

Summary

Gene symbol: mlc-1
Gene description: Myosin regulatory light chain 1
Primary source: WormBase:WBGene00003369
Locus tag: CELE_C36E6.3
See related: AllianceGenome:WB:WBGene00003369
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Predicted to enable calcium ion binding activity. Involved in several processes, including muscle organ development; nematode larval development; and regulation of muscle contraction. Part of muscle myosin complex. Is expressed in anal depressor muscle; body wall musculature; pharynx; and vulval muscle. Human ortholog(s) of this gene implicated in distal arthrogryposis type 1C; familial hypertrophic cardiomyopathy; and hypertrophic cardiomyopathy 10. Orthologous to several human genes including MYL10 (myosin light chain 10); MYL2 (myosin light chain 2); and MYL5 (myosin light chain 5). [provided by Alliance of Genome Resources, Apr 2022]
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Chromosome X - NC_003284.9 Genomic Context describing neighboring genes

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

Function	Evidence Code	Pubs
enables calcium ion binding	IEA Inferred from Electronic Annotation more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables myosin heavy chain binding	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in locomotion	IBA Inferred from Biological aspect of Ancestor more info
involved_in locomotion	IGI Inferred from Genetic Interaction more info	PubMed
involved_in muscle organ development	IGI Inferred from Genetic Interaction more info	PubMed
involved_in nematode larval development	IGI Inferred from Genetic Interaction more info	PubMed
involved_in post-embryonic development	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of muscle contraction	IGI Inferred from Genetic Interaction more info	PubMed

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
part_of muscle myosin complex	IDA Inferred from Direct Assay more info	PubMed
part_of muscle myosin complex	ISS Inferred from Sequence or Structural Similarity more info	PubMed
part_of myosin II complex	IBA Inferred from Biological aspect of Ancestor more info
part_of myosin complex	IEA Inferred from Electronic Annotation more info

NP_510829.2

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The following sections contain reference sequences that belong to a specific genome build. Explain