Stip1 stress-induced phosphoprotein 1 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Stip1provided by RGD
Official Full Name: stress-induced phosphoprotein 1provided by RGD
Primary source: RGD:621599
See related: Ensembl:ENSRNOG00000021164 AllianceGenome:RGD:621599
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Enables Hsp70 protein binding activity; chaperone binding activity; and protein C-terminus binding activity. Predicted to act upstream of or within cellular response to interleukin-7. Part of protein-containing complex. Orthologous to human STIP1 (stress induced phosphoprotein 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Brain (RPKM 436.8), Thymus (RPKM 382.7) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 1q43

Exon count:: 14

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	1	NC_086019.1 (213638641..213657654, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	1	NC_051336.1 (204209433..204228452, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	1	NC_005100.4 (222274133..222293139, complement)

Chromosome 1 - NC_086019.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The potential roles of stress-induced phosphoprotein 1 and connexin 43 in rats with reperfusion arrhythmia.
Title: The potential roles of stress-induced phosphoprotein 1 and connexin 43 in rats with reperfusion arrhythmia.
Stress-induced phosphoprotein 1 restrains spinal cord ischaemia-reperfusion injury by modulating NF-kappaB signalling.
Title: Stress-induced phosphoprotein 1 restrains spinal cord ischaemia-reperfusion injury by modulating NF-κB signalling.
Stip1 has a role in the male reproductive system and is expressed during the stress response
Title: Systematic study of stress-inducible protein 1 (Stip1) in male reproductive system and its expression during stress response.
STI1 participates in Rnd1-induced signal transduction pathways that are involved in the dynamics of the actin cytoskeleton.
Title: STI1 antagonizes cytoskeleton collapse mediated by small GTPase Rnd1 and regulates neurite growth.
stress-inducible protein-1 has a role in recruitment of bone marrow derived cells into the ischemic brains
Title: Role of stress-inducible protein-1 in recruitment of bone marrow derived cells into the ischemic brains.
Hop/STI1 can modulate both proliferation and cell death in the developing retina independent of PrP(C).
Title: Hop/STI1 modulates retinal proliferation and cell death independent of PrPC.
STI1 interaction with PrP(C) affects short-term memory formation and long-term memory consolidation
Title: Short-term memory formation and long-term memory consolidation are enhanced by cellular prion association to stress-inducible protein 1.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables Hsp70 protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables Hsp90 protein binding	IBA Inferred from Biological aspect of Ancestor more info
enables Hsp90 protein binding	ISO Inferred from Sequence Orthology more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein-folding chaperone binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in biological_process	ND No biological Data available more info
involved_in cellular response to interleukin-7	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within cellular response to interleukin-7	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in dynein axonemal particle	ISS Inferred from Sequence or Structural Similarity more info
located_in nucleus	IEA Inferred from Electronic Annotation more info
is_active_in nucleus	ISO Inferred from Sequence Orthology more info
part_of protein folding chaperone complex	ISO Inferred from Sequence Orthology more info
part_of protein-containing complex	IDA Inferred from Direct Assay more info	PubMed
part_of protein-containing complex	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: stress-induced-phosphoprotein 1

Names: STI1; hop; hsc70/Hsp90-organizing protein; stress-induced-phosphoprotein 1 (Hsp70/Hsp90-organizing protein)

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_138911.4 → NP_620266.1 stress-induced-phosphoprotein 1

See identical proteins and their annotated locations for NP_620266.1

Status: VALIDATED

Source sequence(s)

JAXUCZ010000001

UniProtKB/Swiss-Prot

O35814

UniProtKB/TrEMBL

A0A8I6ANI2, A6HZN1

Related

ENSRNOP00000091714.1, ENSRNOT00000116635.1

Conserved Domains (2) summary

TIGR00990
Location:7 → 532

3a0801s09; mitochondrial precursor proteins import receptor (72 kDa mitochondrial outermembrane protein) (mitochondrial import receptor for the ADP/ATP carrier) (translocase of outermembrane tom70)

sd00006
Location:364 → 388

TPR; TPR repeat [structural motif]