terfa telomeric repeat binding factor a [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: terfaprovided by ZNC
Official Full Name: telomeric repeat binding factor aprovided by ZNC
Primary source: ZFIN:ZDB-GENE-020419-38
See related: Ensembl:ENSDARG00000039302 AllianceGenome:ZFIN:ZDB-GENE-020419-38
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: CHUNP6903; wu:fi15d05; wu:fi22b03; zgc:111909; zgc:114011
Summary: Predicted to enable G-rich strand telomeric DNA binding activity and double-stranded telomeric DNA binding activity. Predicted to contribute to telomerase activity. Predicted to be involved in protein localization to chromosome, telomeric region; regulation of telomere maintenance; and telomere maintenance. Predicted to act upstream of or within telomere maintenance. Predicted to be located in nucleus. Predicted to be part of shelterin complex. Is expressed in several structures, including gill; heart; liver; nervous system; and pleuroperitoneal region. Orthologous to human TERF2 (telomeric repeat binding factor 2). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 4

Exon count:: 16

Annotation release	Status	Assembly	Chr	Location
106	current	GRCz11 (GCF_000002035.6)	4	NC_007115.7 (77973874..77996958)
105	previous assembly	GRCz10 (GCF_000002035.5)	4	NC_007115.6 (76589172..76612256)

Chromosome 4 - NC_007115.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Solution structure of the Myb domain of Terfa derived from Zebrafish interacting with both human and plant telomeric DNA.
Title: Solution structure of the Myb domain of Terfa derived from Zebrafish interacting with both human and plant telomeric DNA.

Submit: New GeneRIF Correction

General gene information

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Markers

fi15d05.x1 (e-PCR)
- UniSTS:196873

fb93f02.y1 (e-PCR)
- UniSTS:191798

fi22b03.x1 (e-PCR)
- UniSTS:197035

fa66f10 (e-PCR)
- UniSTS:188845

Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables DNA binding	IEA Inferred from Electronic Annotation more info
enables G-rich strand telomeric DNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables double-stranded telomeric DNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables protein homodimerization activity	IEA Inferred from Electronic Annotation more info
contributes_to telomerase activity	IBA Inferred from Biological aspect of Ancestor more info
enables telomeric DNA binding	IDA Inferred from Direct Assay more info	PubMed
enables telomeric DNA binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within cell cycle	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of telomere maintenance via recombination	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of telomeric D-loop disassembly	IBA Inferred from Biological aspect of Ancestor more info
involved_in protection from non-homologous end joining at telomere	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within protection from non-homologous end joining at telomere	IEA Inferred from Electronic Annotation more info
involved_in protein localization to chromosome, telomeric region	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of telomere maintenance via telomerase	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within telomere maintenance	IEA Inferred from Electronic Annotation more info
involved_in telomeric D-loop disassembly	IBA Inferred from Biological aspect of Ancestor more info
involved_in telomeric loop formation	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
located_in chromosome	IEA Inferred from Electronic Annotation more info
located_in chromosome, telomeric region	IEA Inferred from Electronic Annotation more info
located_in nucleus	IEA Inferred from Electronic Annotation more info
part_of shelterin complex	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: telomeric repeat binding factor a; telomeric repeat-binding factor 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_173243.2 → NP_775350.2 telomeric repeat binding factor a

Status: VALIDATED

Source sequence(s)

CU695140

UniProtKB/TrEMBL

A0A8N7UZT2, F1Q8U5, F1QRC8, Q4FZZ9

Related

ENSDARP00000057422.5, ENSDART00000057423.8

Conserved Domains (3) summary

smart00717
Location:524 → 570

SANT; SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains

cd11660
Location:522 → 570

SANT_TRF; Telomere repeat binding factor-like DNA-binding domains of the SANT/myb-like family

cd00280
Location:7 → 203

TRFH; Telomeric Repeat binding Factor or TTAGGG Repeat binding Factor, central (dimerization) domain Homology; TRFH. Telomeres are protein/DNA complexes that make up the physical ends of eukaryotic linear chromosomes and are essential for chromosome stability, ...

RefSeqs of Annotated Genomes: Danio rerio Annotation Release 106 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

NC_007115.7 Reference GRCz11 Primary Assembly

Range

77973874..77996958

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_021474924.1 → XP_021330599.1 telomeric repeat-binding factor 2 isoform X4

UniProtKB/TrEMBL

A0A8M9Q073, Q8JGS4

Conserved Domains (2) summary

cd11660
Location:493 → 541

SANT_TRF; Telomere repeat binding factor-like DNA-binding domains of the SANT/myb-like family

cd00280
Location:7 → 203

TRFH; Telomeric Repeat binding Factor or TTAGGG Repeat binding Factor, central (dimerization) domain Homology; TRFH. Telomeres are protein/DNA complexes that make up the physical ends of eukaryotic linear chromosomes and are essential for chromosome stability, ...
XM_021474925.1 → XP_021330600.1 telomeric repeat-binding factor 2 isoform X5

UniProtKB/TrEMBL

A0A8M9QAZ0, Q8JGS4

Conserved Domains (2) summary

cd11660
Location:457 → 505

SANT_TRF; Telomere repeat binding factor-like DNA-binding domains of the SANT/myb-like family

cd00280
Location:7 → 203

TRFH; Telomeric Repeat binding Factor or TTAGGG Repeat binding Factor, central (dimerization) domain Homology; TRFH. Telomeres are protein/DNA complexes that make up the physical ends of eukaryotic linear chromosomes and are essential for chromosome stability, ...
XM_009301104.3 → XP_009299379.1 telomeric repeat-binding factor 2 isoform X2

UniProtKB/TrEMBL

A0A8M3B9A0, Q4FZZ9

Conserved Domains (3) summary

smart00717
Location:559 → 605

SANT; SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains

cd11660
Location:557 → 605

SANT_TRF; Telomere repeat binding factor-like DNA-binding domains of the SANT/myb-like family

cd00280
Location:7 → 202

TRFH; Telomeric Repeat binding Factor or TTAGGG Repeat binding Factor, central (dimerization) domain Homology; TRFH. Telomeres are protein/DNA complexes that make up the physical ends of eukaryotic linear chromosomes and are essential for chromosome stability, ...
XM_009301103.3 → XP_009299378.1 telomeric repeat-binding factor 2 isoform X1

UniProtKB/TrEMBL

A0A8M3ART8, Q4FZZ9

Conserved Domains (3) summary

smart00717
Location:560 → 606

SANT; SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains

cd11660
Location:558 → 606

SANT_TRF; Telomere repeat binding factor-like DNA-binding domains of the SANT/myb-like family

cd00280
Location:7 → 203

TRFH; Telomeric Repeat binding Factor or TTAGGG Repeat binding Factor, central (dimerization) domain Homology; TRFH. Telomeres are protein/DNA complexes that make up the physical ends of eukaryotic linear chromosomes and are essential for chromosome stability, ...
XM_009301105.3 → XP_009299380.1 telomeric repeat-binding factor 2 isoform X3

UniProtKB/TrEMBL

A0A8N7UZT2, F1Q8U5, F1QRC8, Q4FZZ9

Related

ENSDARP00000105024.2, ENSDART00000122459.3

Conserved Domains (3) summary

smart00717
Location:524 → 570

SANT; SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains

cd11660
Location:522 → 570

SANT_TRF; Telomere repeat binding factor-like DNA-binding domains of the SANT/myb-like family

cd00280
Location:7 → 203

TRFH; Telomeric Repeat binding Factor or TTAGGG Repeat binding Factor, central (dimerization) domain Homology; TRFH. Telomeres are protein/DNA complexes that make up the physical ends of eukaryotic linear chromosomes and are essential for chromosome stability, ...