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Mobp myelin-associated oligodendrocyte basic protein [ Rattus norvegicus (Norway rat) ]

Gene ID: 25037, updated on 13-Apr-2024

Summary

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Official Symbol
Mobpprovided by RGD
Official Full Name
myelin-associated oligodendrocyte basic proteinprovided by RGD
Primary source
RGD:3101
See related
Ensembl:ENSRNOG00000018700 AllianceGenome:RGD:3101
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Mobp81; Mobp81p
Summary
A structural constituent of myelin sheath. Involved in central nervous system myelin formation. Located in myelin sheath. Biomarker of hypothyroidism. Human ortholog(s) of this gene implicated in frontotemporal dementia. Orthologous to human MOBP (myelin associated oligodendrocyte basic protein). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Restricted expression toward (RPKM 1659.9) See more
Orthologs
human mouse all
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Genomic context

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Location:
8q32
Exon count:
8
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 8 NC_086026.1 (128747117..128777238)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 8 NC_051343.1 (119869504..119899605)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 8 NC_005107.4 (128824420..128854492)

Chromosome 8 - NC_086026.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC134480248 Neighboring gene small nucleolar RNA, H/ACA box 62 Neighboring gene ribosomal protein SA Neighboring gene uncharacterized LOC102549288 Neighboring gene mitochondrial ribosome recycling factor, pseudogene 2

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Gene expression changes in a rat model of oxygen-induced retinopathy. Lee NE, et al. Korean J Ophthalmol, 2011 Feb. PMID 21350694, Free PMC Article
  2. Myelin-associated oligodendrocytic basic protein: identification of an encephalitogenic epitope and association with multiple sclerosis. Holz A, et al. J Immunol, 2000 Jan 15. PMID 10623862
  3. Developmental expression of the myelin gene MOBP in the rat nervous system. Holz A, et al. J Neurocytol, 1997 Jul. PMID 9306245
  4. Myelin oligodendrocyte basic protein and prognosis in behavioral-variant frontotemporal dementia. Irwin DJ, et al. Neurology, 2014 Aug 5. PMID 24994843, Free PMC Article
  5. Characterization of the murine splice variant Mobp155: developmental CNS expression pattern and subcellular localization of epitope-tagged protein. Montague P, et al. Glia, 2005 Apr 1. PMID 15625715

See all (17) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • MGC105491

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables structural constituent of myelin sheath IDA
Inferred from Direct Assay
more info
 PubMed 
enables structural constituent of myelin sheath ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in central nervous system myelin formation IEP
Inferred from Expression Pattern
more info
 PubMed 
involved_in nervous system development IEP
Inferred from Expression Pattern
more info
 PubMed 
Component Evidence Code Pubs
located_in mitochondrion ISO
Inferred from Sequence Orthology
more info
  
located_in perinuclear region of cytoplasm IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
myelin-associated oligodendrocyte basic protein
Names
Myelin-associated/Oligodendrocytic Basic Protein-81
RNMOBP81P
myelin-associated oligodendrocytic basic protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001389272.1 → NP_001376201.1  myelin-associated oligodendrocyte basic protein isoform 2

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000008
    UniProtKB/Swiss-Prot
    Q63327, Q63328, Q63343, Q63519, Q64266, Q9QZV5
    UniProtKB/TrEMBL
    B1WBR5
    Conserved Domains (1) summary
    cl22851
    Location:1 → 68
    PHD_SF; PHD finger superfamily

  2. NM_001389273.1 → NP_001376202.1  myelin-associated oligodendrocyte basic protein isoform 2

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000008
    UniProtKB/Swiss-Prot
    Q63327, Q63328, Q63343, Q63519, Q64266, Q9QZV5
    UniProtKB/TrEMBL
    B1WBR5
    Related
    ENSRNOP00000025279.3, ENSRNOT00000025279.6
    Conserved Domains (1) summary
    cl22851
    Location:1 → 68
    PHD_SF; PHD finger superfamily

  3. NM_012720.2 → NP_036852.1  myelin-associated oligodendrocyte basic protein isoform 1

    See identical proteins and their annotated locations for NP_036852.1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000008
    UniProtKB/TrEMBL
    A6I401
    Related
    ENSRNOP00000025344.5, ENSRNOT00000025343.9
    Conserved Domains (1) summary
    cl22851
    Location:1 → 67
    PHD_SF; PHD finger superfamily

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086026.1 Reference GRCr8

    Range
    128747117..128777238
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039080858.2 → XP_038936786.1  myelin-associated oligodendrocyte basic protein isoform X1

    UniProtKB/Swiss-Prot
    Q63327, Q63328, Q63343, Q63519, Q64266, Q9QZV5
    UniProtKB/TrEMBL
    B1WBR5
    Conserved Domains (1) summary
    cl22851
    Location:1 → 68
    PHD_SF; PHD finger superfamily

  2. XM_039080854.2 → XP_038936782.1  myelin-associated oligodendrocyte basic protein isoform X1

    UniProtKB/Swiss-Prot
    Q63327, Q63328, Q63343, Q63519, Q64266, Q9QZV5
    UniProtKB/TrEMBL
    B1WBR5
    Conserved Domains (1) summary
    cl22851
    Location:1 → 68
    PHD_SF; PHD finger superfamily

  3. XM_039080855.2 → XP_038936783.1  myelin-associated oligodendrocyte basic protein isoform X1

    UniProtKB/Swiss-Prot
    Q63327, Q63328, Q63343, Q63519, Q64266, Q9QZV5
    UniProtKB/TrEMBL
    B1WBR5
    Conserved Domains (1) summary
    cl22851
    Location:1 → 68
    PHD_SF; PHD finger superfamily

  4. XM_039080856.2 → XP_038936784.1  myelin-associated oligodendrocyte basic protein isoform X1

    UniProtKB/Swiss-Prot
    Q63327, Q63328, Q63343, Q63519, Q64266, Q9QZV5
    UniProtKB/TrEMBL
    B1WBR5
    Conserved Domains (1) summary
    cl22851
    Location:1 → 68
    PHD_SF; PHD finger superfamily

  5. XM_039080860.2 → XP_038936788.1  myelin-associated oligodendrocyte basic protein isoform X2

    UniProtKB/TrEMBL
    A6I402
    Conserved Domains (1) summary
    cl22851
    Location:1 → 68
    PHD_SF; PHD finger superfamily

  6. XM_039080862.2 → XP_038936790.1  myelin-associated oligodendrocyte basic protein isoform X3

    UniProtKB/TrEMBL
    A6I401
    Conserved Domains (1) summary
    cl22851
    Location:1 → 67
    PHD_SF; PHD finger superfamily

  7. XM_039080859.1 → XP_038936787.1  myelin-associated oligodendrocyte basic protein isoform X1

    UniProtKB/Swiss-Prot
    Q63327, Q63328, Q63343, Q63519, Q64266, Q9QZV5
    UniProtKB/TrEMBL
    B1WBR5
    Conserved Domains (1) summary
    cl22851
    Location:1 → 68
    PHD_SF; PHD finger superfamily

  8. XM_063264939.1 → XP_063121009.1  myelin-associated oligodendrocyte basic protein isoform X2

    UniProtKB/TrEMBL
    A6I402

  9. XM_039080863.2 → XP_038936791.1  myelin-associated oligodendrocyte basic protein isoform X3

    UniProtKB/TrEMBL
    A6I401
    Conserved Domains (1) summary
    cl22851
    Location:1 → 67
    PHD_SF; PHD finger superfamily

  10. XM_039080857.2 → XP_038936785.1  myelin-associated oligodendrocyte basic protein isoform X1

    UniProtKB/Swiss-Prot
    Q63327, Q63328, Q63343, Q63519, Q64266, Q9QZV5
    UniProtKB/TrEMBL
    B1WBR5
    Conserved Domains (1) summary
    cl22851
    Location:1 → 68
    PHD_SF; PHD finger superfamily

  11. XM_039080861.1 → XP_038936789.1  myelin-associated oligodendrocyte basic protein isoform X2

    UniProtKB/TrEMBL
    A6I402
    Conserved Domains (1) summary
    cl22851
    Location:1 → 68
    PHD_SF; PHD finger superfamily

  12. XM_063264940.1 → XP_063121010.1  myelin-associated oligodendrocyte basic protein isoform X3

    UniProtKB/TrEMBL
    A6I401
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q63327.1 GenPept UniProtKB/Swiss-Prot:Q63327

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