h2az2a H2A.Z variant histone 2a [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: h2az2aprovided by ZNC
Official Full Name: H2A.Z variant histone 2aprovided by ZNC
Primary source: ZFIN:ZDB-GENE-020717-1
See related: Ensembl:ENSDARG00000068820 AllianceGenome:ZFIN:ZDB-GENE-020717-1
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: h2afv; h2afz; h2aza; h2afva; H2A.F/Z
Summary: Predicted to enable DNA binding activity. Predicted to be involved in heterochromatin assembly. Predicted to be located in chromosome and nucleus. Predicted to be part of nucleosome. Is expressed in ovarian follicle. Orthologous to human H2AZ2 (H2A.Z variant histone 2). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs: all
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Genomic context

Location:: chromosome: 5

Exon count:: 5

Annotation release	Status	Assembly	Chr	Location
106	current	GRCz11 (GCF_000002035.6)	5	NC_007116.7 (13647219..13652687)
105	previous assembly	GRCz10 (GCF_000002035.5)	5	NC_007116.6 (13147044..13152470)

Chromosome 5 - NC_007116.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables DNA binding	IEA Inferred from Electronic Annotation more info
enables nucleosomal DNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables protein heterodimerization activity	IEA Inferred from Electronic Annotation more info
enables structural constituent of chromatin	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in heterochromatin formation	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within positive regulation of melanocyte differentiation	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in chromosome	IEA Inferred from Electronic Annotation more info
located_in membrane	IEA Inferred from Electronic Annotation more info
part_of nucleosome	IBA Inferred from Biological aspect of Ancestor more info
part_of nucleosome	IEA Inferred from Electronic Annotation more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: histone H2A.V

Names: H2A histone family, member V; H2A histone family, member Va; H2A histone family, member Z

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_153644.1 → NP_705930.1 histone H2A.V

See identical proteins and their annotated locations for NP_705930.1

Status: PROVISIONAL

Source sequence(s)

AF414110

UniProtKB/Swiss-Prot

Q71PD7

UniProtKB/TrEMBL

A2BFY9

Related

ENSDARP00000090434.4, ENSDART00000099660.6

Conserved Domains (1) summary

PLN00154
Location:6 → 121

PLN00154; histone H2A; Provisional

RefSeqs of Annotated Genomes: Danio rerio Annotation Release 106 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

NC_007116.7 Reference GRCz11 Primary Assembly

Range

13647219..13652687

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_005165036.3 → XP_005165093.1 histone H2A.V isoform X1

UniProtKB/TrEMBL

A0A8M2BCB5

Conserved Domains (1) summary

cd00074
Location:8 → 109

H2A; Histone 2A; H2A is a subunit of the nucleosome. The nucleosome is an octamer containing two H2A, H2B, H3, and H4 subunits. The H2A subunit performs essential roles in maintaining structural integrity of the nucleosome, chromatin condensation, and binding ...