tor2 phosphatidylinositol kinase Tor2 [Schizosaccharomyces pombe (fission yeast)] - Gene

Summary

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Gene symbol: tor2
Gene description: phosphatidylinositol kinase Tor2
Primary source: PomBase:SPBC216.07c
Locus tag: SPBC216.07c
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Schizosaccharomyces pombe (strain: 972h-)
Lineage: Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina; Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae; Schizosaccharomyces
Also known as: SPBC646.01c
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Genomic context

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See tor2 in Genome Data Viewer

Location:: chromosome: II

Exon count:: 1

Sequence:: Chromosome: II; NC_003423.3 (915085..922447, complement)

Chromosome II - NC_003423.3 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003423.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

TOR targets an RNA processing network to regulate facultative heterochromatin, developmental gene expression and cell proliferation.
Title: TOR targets an RNA processing network to regulate facultative heterochromatin, developmental gene expression and cell proliferation.
Data indicate that AMP-activated protein kinase beta subunit Amk2 (Amk2) and glycogen synthase kinase 3 (Gsk3) act in parallel to inhibit TORC1 (Tor2) function.
Title: Genetic interactions and functional analyses of the fission yeast gsk3 and amk2 single and double mutants defective in TORC1-dependent processes.
Since Gaf1 was also critical for transcription of per1+ and put4+, Tor-Gaf1 signaling may coordinate transcription of multiple amino acid permeases according to nutrient availability
Title: Tor Signaling Regulates Transcription of Amino Acid Permeases through a GATA Transcription Factor Gaf1 in Fission Yeast.
These results suggest that nitrogen depletion decreases Tor2 activity through Tsc2, thereby promoting the surface expression of Agp3 from trans-Golgi/endosomes.
Title: Constitutive Tor2 Activity Promotes Retention of the Amino Acid Transporter Agp3 at Trans-Golgi/Endosomes in Fission Yeast.
Data show that the newly synthesized glucose transport Ght5 locates preferentially at the cell tips with the aid of the target of rapamycin (TOR) complex 2 signaling.
Title: Mechanisms of expression and translocation of major fission yeast glucose transporters regulated by CaMKK/phosphatases, nuclear shuttling, and TOR.
While mutated TORC1 and TORC2 displayed diminished kinase activity and FKBP12/Fkh1-dependent rapamycin sensitivity, their phenotypes were nearly opposite in mitosis.
Title: The reverse, but coordinated, roles of Tor2 (TORC1) and Tor1 (TORC2) kinases for growth, cell cycle and separase-mediated mitosis in Schizosaccharomyces pombe.
Rapamycin inactivates Tor2 activity in the presence of caffeine.
Title: TORC1 of fission yeast is rapamycin-sensitive.
The double mutant tor2-51 pka1Delta showed a faster rate of accumulation of cells with 1C DNA content, indicating that the TOR and the PKA pathways cooperate to prevent cell cycle exit and G1 arrest in fission yeast.
Title: TOR and PKA pathways synergize at the level of the Ste11 transcription factor to prevent mating and meiosis in fission yeast.
Rapamycin inhibits the ability of TORC1 to phosphorylate Rps6, owing to interaction of the rapamycin-FKBP12 complex with the FRB domain in Tor2
Title: Fission yeast TORC1 regulates phosphorylation of ribosomal S6 proteins in response to nutrients and its activity is inhibited by rapamycin.
Studies postulate that the signaling cascade may branch below Rhb1 or Tor2 and regulate the amino acid uptake and response to nitrogen starvation independently.
Title: Distinctive responses to nitrogen starvation in the dominant active mutants of the fission yeast Rheb GTPase.

Submit: New GeneRIF Correction See all GeneRIFs (11)

Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Orthologs from OrthoDB

Gene Ontology Provided by PomBase

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein kinase activity	IDA Inferred from Direct Assay more info	PubMed
enables protein serine/threonine kinase activity	EXP Inferred from Experiment more info	PubMed
enables protein serine/threonine kinase activity	IBA Inferred from Biological aspect of Ancestor more info
enables protein serine/threonine kinase activity	IDA Inferred from Direct Assay more info	PubMed
enables rRNA primary transcript binding	EXP Inferred from Experiment more info	PubMed

Process	Evidence Code	Pubs
involved_in TORC1 signaling	IBA Inferred from Biological aspect of Ancestor more info
involved_in TORC1 signaling	IDA Inferred from Direct Assay more info	PubMed
involved_in TORC1 signaling	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of G2/M transition of mitotic cell cycle	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of cell cycle switching, mitotic to meiotic cell cycle	EXP Inferred from Experiment more info	PubMed
involved_in negative regulation of cell cycle switching, mitotic to meiotic cell cycle	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of induction of conjugation with cellular fusion	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of macroautophagy	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of macroautophagy	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of rDNA heterochromatin formation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of G1/S transition of mitotic cell cycle	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of cell growth	EXP Inferred from Experiment more info	PubMed
involved_in positive regulation of cytoplasmic translation	EXP Inferred from Experiment more info	PubMed
involved_in positive regulation of cytoplasmic translation	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of nuclear-transcribed mRNA catabolic process, meiosis-specific transcripts	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of proteasomal ubiquitin-dependent protein catabolic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of ribosomal protein gene transcription by RNA polymerase II	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
part_of TORC1 complex	IBA Inferred from Biological aspect of Ancestor more info
part_of TORC1 complex	IDA Inferred from Direct Assay more info	PubMed
part_of TORC2 complex	IBA Inferred from Biological aspect of Ancestor more info
part_of Tor2-Mei2-Ste11 complex	IDA Inferred from Direct Assay more info	PubMed
part_of chromatin	IDA Inferred from Direct Assay more info	PubMed
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
is_active_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
is_active_in cytosol	HDA more info	PubMed
is_active_in nucleolar chromatin	IDA Inferred from Direct Assay more info	PubMed
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
is_active_in nucleus	IDA Inferred from Direct Assay more info	PubMed
is_active_in perinuclear region of cytoplasm	IDA Inferred from Direct Assay more info	PubMed
is_active_in vacuolar membrane	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: phosphatidylinositol kinase Tor2

NP_595359.2

EC 2.7.1.137

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003423.3 Reference assembly

Range

915085..922447 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001021266.3 → NP_595359.2 phosphatidylinositol kinase Tor2 [Schizosaccharomyces pombe]

See identical proteins and their annotated locations for NP_595359.2

Status: PROVISIONAL

UniProtKB/Swiss-Prot

O94507, Q9Y7K2

Conserved Domains (7) summary

COG5032
Location:194 → 2337

TEL1; Phosphatidylinositol kinase or protein kinase, PI-3 family [Signal transduction mechanisms]

cd05169
Location:1955 → 2233

PIKKc_TOR; Catalytic domain of Target of Rapamycin

pfam02260
Location:2307 → 2337

FATC; FATC domain

pfam08771
Location:1817 → 1914

Rapamycin_bind; Rapamycin binding domain

pfam11865
Location:722 → 880

DUF3385; Domain of unknown function (DUF3385)

pfam13513
Location:662 → 715

HEAT_EZ; HEAT-like repeat

sd00044
Location:565 → 592

HEAT; HEAT repeat [structural motif]