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Lpp LIM domain containing preferred translocation partner in lipoma [ Rattus norvegicus (Norway rat) ]

Gene ID: 288010, updated on 11-Apr-2024

Summary

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Official Symbol
Lppprovided by RGD
Official Full Name
LIM domain containing preferred translocation partner in lipomaprovided by RGD
Primary source
RGD:1310535
See related
Ensembl:ENSRNOG00000031669 AllianceGenome:RGD:1310535
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable metal ion binding activity. Predicted to be involved in cell-cell adhesion. Predicted to be located in cytosol. Predicted to be active in focal adhesion and stress fiber. Human ortholog(s) of this gene implicated in acute myeloid leukemia. Orthologous to human LPP (LIM domain containing preferred translocation partner in lipoma). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Uterus (RPKM 204.6), Lung (RPKM 181.5) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Lpp in Genome Data Viewer
Location:
11q23
Exon count:
21
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 11 NC_086029.1 (89292060..89933973, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 11 NC_051346.1 (75787326..76426646, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 11 NC_005110.4 (79192603..79827858, complement)

Chromosome 11 - NC_086029.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC134481022 Neighboring gene splicing factor 3A subunit 2, pseudogene 1 Neighboring gene uncharacterized LOC100910319 Neighboring gene small nucleolar RNA SNORA17 Neighboring gene microRNA 28 Neighboring gene 40S ribosomal protein S3a-like Neighboring gene uncharacterized LOC108352383 Neighboring gene U7 small nuclear RNA Neighboring gene myosin light chain 6, pseudogene 5 Neighboring gene LIM domain containing preferred translocation partner in lipoma, opposite strand Neighboring gene uncharacterized LOC102553750

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Modulation of stretch-induced myocyte remodeling and gene expression by nitric oxide: a novel role for lipoma preferred partner in myofibrillogenesis. Hooper CL, et al. Am J Physiol Heart Circ Physiol, 2013 May 15. PMID 23504181, Free PMC Article
  2. Quantitative phosphoproteomics of vasopressin-sensitive renal cells: regulation of aquaporin-2 phosphorylation at two sites. Hoffert JD, et al. Proc Natl Acad Sci U S A, 2006 May 2. PMID 16641100, Free PMC Article
  3. Analysis of the myosin-II-responsive focal adhesion proteome reveals a role for β-Pix in negative regulation of focal adhesion maturation. Kuo JC, et al. Nat Cell Biol, 2011 Apr. PMID 21423176, Free PMC Article
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Gerhard DS, et al. Genome Res, 2004 Oct. PMID 15489334, Free PMC Article
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

See all (6) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. LPP knockdown by small intefering RNA led to formation of alpha-actinin aggregates and Z bodies showing that myofibrillogenesis was impaired
    Title: Modulation of stretch-induced myocyte remodeling and gene expression by nitric oxide: a novel role for lipoma preferred partner in myofibrillogenesis.
Submit: New GeneRIF Correction

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
involved_in biological_process ND
No biological Data available
more info
  
involved_in cell-cell adhesion IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in cellular_component ND
No biological Data available
more info
  
located_in cytosol IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
is_active_in focal adhesion IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in focal adhesion ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  
is_active_in stress fiber IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
lipoma-preferred partner homolog
Names
Lipoma-preferred-partner

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001013864.1 → NP_001013886.1  lipoma-preferred partner homolog

    See identical proteins and their annotated locations for NP_001013886.1

    Status: PROVISIONAL

    Source sequence(s)
    BC083627
    UniProtKB/Swiss-Prot
    Q5XI07
    UniProtKB/TrEMBL
    A0A8I6A5H9
    Related
    ENSRNOP00000090019.1, ENSRNOT00000113595.1
    Conserved Domains (3) summary
    cd09350
    Location:436 → 489
    LIM1_TRIP6; The first LIM domain of Thyroid receptor-interacting protein 6 (TRIP6)
    PHA03247
    Location:4 → 367
    PHA03247; large tegument protein UL36; Provisional
    cl02475
    Location:556 → 621
    LIM; LIM is a small protein-protein interaction domain, containing two zinc fingers

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086029.1 Reference GRCr8

    Range
    89292060..89933973 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_063270369.1 → XP_063126439.1  lipoma-preferred partner homolog isoform X3

  2. XM_039088098.2 → XP_038944026.1  lipoma-preferred partner homolog isoform X2

    Conserved Domains (4) summary
    cd09350
    Location:578 → 631
    LIM1_TRIP6; The first LIM domain of Thyroid receptor-interacting protein 6 (TRIP6)
    cd09436
    Location:698 → 763
    LIM3_TRIP6; The third LIM domain of Thyroid receptor-interacting protein 6 (TRIP6)
    PHA03247
    Location:169 → 552
    PHA03247; large tegument protein UL36; Provisional
    cl02475
    Location:638 → 697
    LIM; LIM is a small protein-protein interaction domain, containing two zinc fingers

  3. XM_039088097.2 → XP_038944025.1  lipoma-preferred partner homolog isoform X1

    Conserved Domains (5) summary
    cd09350
    Location:601 → 654
    LIM1_TRIP6; The first LIM domain of Thyroid receptor-interacting protein 6 (TRIP6)
    cd09436
    Location:721 → 786
    LIM3_TRIP6; The third LIM domain of Thyroid receptor-interacting protein 6 (TRIP6)
    PHA03247
    Location:15 → 429
    PHA03247; large tegument protein UL36; Provisional
    PRK14086
    Location:347 → 534
    dnaA; chromosomal replication initiator protein DnaA
    cl02475
    Location:661 → 720
    LIM; LIM is a small protein-protein interaction domain, containing two zinc fingers

  4. XM_039088099.2 → XP_038944027.1  lipoma-preferred partner homolog isoform X4

    UniProtKB/Swiss-Prot
    Q5XI07
    UniProtKB/TrEMBL
    A0A8I6A5H9
    Conserved Domains (3) summary
    cd09350
    Location:436 → 489
    LIM1_TRIP6; The first LIM domain of Thyroid receptor-interacting protein 6 (TRIP6)
    PHA03247
    Location:4 → 367
    PHA03247; large tegument protein UL36; Provisional
    cl02475
    Location:556 → 621
    LIM; LIM is a small protein-protein interaction domain, containing two zinc fingers

  5. XM_017597911.3 → XP_017453400.1  lipoma-preferred partner homolog isoform X4

    UniProtKB/Swiss-Prot
    Q5XI07
    UniProtKB/TrEMBL
    A0A8I6A5H9
    Conserved Domains (3) summary
    cd09350
    Location:436 → 489
    LIM1_TRIP6; The first LIM domain of Thyroid receptor-interacting protein 6 (TRIP6)
    PHA03247
    Location:4 → 367
    PHA03247; large tegument protein UL36; Provisional
    cl02475
    Location:556 → 621
    LIM; LIM is a small protein-protein interaction domain, containing two zinc fingers

  6. XM_017597913.3 → XP_017453402.1  lipoma-preferred partner homolog isoform X4

    UniProtKB/Swiss-Prot
    Q5XI07
    UniProtKB/TrEMBL
    A0A8I6A5H9
    Conserved Domains (3) summary
    cd09350
    Location:436 → 489
    LIM1_TRIP6; The first LIM domain of Thyroid receptor-interacting protein 6 (TRIP6)
    PHA03247
    Location:4 → 367
    PHA03247; large tegument protein UL36; Provisional
    cl02475
    Location:556 → 621
    LIM; LIM is a small protein-protein interaction domain, containing two zinc fingers

  7. XM_017597910.3 → XP_017453399.1  lipoma-preferred partner homolog isoform X4

    UniProtKB/Swiss-Prot
    Q5XI07
    UniProtKB/TrEMBL
    A0A8I6A5H9
    Conserved Domains (3) summary
    cd09350
    Location:436 → 489
    LIM1_TRIP6; The first LIM domain of Thyroid receptor-interacting protein 6 (TRIP6)
    PHA03247
    Location:4 → 367
    PHA03247; large tegument protein UL36; Provisional
    cl02475
    Location:556 → 621
    LIM; LIM is a small protein-protein interaction domain, containing two zinc fingers

  8. XM_006248505.5 → XP_006248567.1  lipoma-preferred partner homolog isoform X4

    See identical proteins and their annotated locations for XP_006248567.1

    UniProtKB/Swiss-Prot
    Q5XI07
    UniProtKB/TrEMBL
    A0A8I6A5H9
    Conserved Domains (3) summary
    cd09350
    Location:436 → 489
    LIM1_TRIP6; The first LIM domain of Thyroid receptor-interacting protein 6 (TRIP6)
    PHA03247
    Location:4 → 367
    PHA03247; large tegument protein UL36; Provisional
    cl02475
    Location:556 → 621
    LIM; LIM is a small protein-protein interaction domain, containing two zinc fingers

  9. XM_017597912.3 → XP_017453401.1  lipoma-preferred partner homolog isoform X4

    UniProtKB/Swiss-Prot
    Q5XI07
    UniProtKB/TrEMBL
    A0A8I6A5H9
    Conserved Domains (3) summary
    cd09350
    Location:436 → 489
    LIM1_TRIP6; The first LIM domain of Thyroid receptor-interacting protein 6 (TRIP6)
    PHA03247
    Location:4 → 367
    PHA03247; large tegument protein UL36; Provisional
    cl02475
    Location:556 → 621
    LIM; LIM is a small protein-protein interaction domain, containing two zinc fingers

  10. XM_039088102.2 → XP_038944030.1  lipoma-preferred partner homolog isoform X4

    UniProtKB/Swiss-Prot
    Q5XI07
    UniProtKB/TrEMBL
    A0A8I6A5H9
    Conserved Domains (3) summary
    cd09350
    Location:436 → 489
    LIM1_TRIP6; The first LIM domain of Thyroid receptor-interacting protein 6 (TRIP6)
    PHA03247
    Location:4 → 367
    PHA03247; large tegument protein UL36; Provisional
    cl02475
    Location:556 → 621
    LIM; LIM is a small protein-protein interaction domain, containing two zinc fingers

  11. XM_063270371.1 → XP_063126441.1  lipoma-preferred partner homolog isoform X5

    UniProtKB/TrEMBL
    A0A8L2QL16, A6JS03

  12. XM_017597915.3 → XP_017453404.1  lipoma-preferred partner homolog isoform X4

    UniProtKB/Swiss-Prot
    Q5XI07
    UniProtKB/TrEMBL
    A0A8I6A5H9
    Conserved Domains (3) summary
    cd09350
    Location:436 → 489
    LIM1_TRIP6; The first LIM domain of Thyroid receptor-interacting protein 6 (TRIP6)
    PHA03247
    Location:4 → 367
    PHA03247; large tegument protein UL36; Provisional
    cl02475
    Location:556 → 621
    LIM; LIM is a small protein-protein interaction domain, containing two zinc fingers

  13. XM_063270372.1 → XP_063126442.1  lipoma-preferred partner homolog isoform X5

    UniProtKB/TrEMBL
    A0A8L2QL16, A6JS03

  14. XM_017597918.3 → XP_017453407.1  lipoma-preferred partner homolog isoform X4

    UniProtKB/Swiss-Prot
    Q5XI07
    UniProtKB/TrEMBL
    A0A8I6A5H9
    Related
    ENSRNOP00000087235.1
    Conserved Domains (3) summary
    cd09350
    Location:436 → 489
    LIM1_TRIP6; The first LIM domain of Thyroid receptor-interacting protein 6 (TRIP6)
    PHA03247
    Location:4 → 367
    PHA03247; large tegument protein UL36; Provisional
    cl02475
    Location:556 → 621
    LIM; LIM is a small protein-protein interaction domain, containing two zinc fingers

  15. XM_006248507.4 → XP_006248569.1  lipoma-preferred partner homolog isoform X6

    UniProtKB/TrEMBL
    A0A8I6A5H9
    Related
    ENSRNOP00000083451.1
    Conserved Domains (2) summary
    cd09350
    Location:311 → 364
    LIM1_TRIP6; The first LIM domain of Thyroid receptor-interacting protein 6 (TRIP6)
    cl02475
    Location:431 → 496
    LIM; LIM is a small protein-protein interaction domain, containing two zinc fingers

  16. XM_063270373.1 → XP_063126443.1  lipoma-preferred partner homolog isoform X7

    UniProtKB/TrEMBL
    A0A8I5ZVW3

  17. XM_039088103.2 → XP_038944031.1  lipoma-preferred partner homolog isoform X8

    UniProtKB/TrEMBL
    A0A8I6A5H9
    Conserved Domains (3) summary
    cd09350
    Location:272 → 325
    LIM1_TRIP6; The first LIM domain of Thyroid receptor-interacting protein 6 (TRIP6)
    PRK14086
    Location:18 → 205
    dnaA; chromosomal replication initiator protein DnaA
    cl02475
    Location:392 → 457
    LIM; LIM is a small protein-protein interaction domain, containing two zinc fingers
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q5XI07.1 GenPept UniProtKB/Swiss-Prot:Q5XI07

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